Differential response of the natriuretic peptide system to weight loss and exercise in overweight or obese patients

Haufe, Sven; Kaminski, Jana; Utz, Wolfgang; Haas, Verena; Mähler, Anja; Daniels, Martin A.; Birkenfeld, Andreas L.; Lichtinghagen, Ralf; Luft, Friedrich C.; Schulz‐Menger, Jeanette; Engeli, Stefan; Jordan, Jens

doi:10.1097/hjh.0000000000000573

Cited by 36 publications

(30 citation statements)

References 36 publications

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“…However, weight loss studies, either involving caloric restriction or gastric bypass surgery, indicated increased systemic NP levels (i.e. N-terminal proBNP) (210)(211)(212)(213)(214)(215), which was not confirmed in all studies (200,216,217). In the comparison of these interventions, it was recently shown that the amount of weight loss is associated with the increase in systemic NP concentrations (218).…”

Section: Lifestyle Interventions and Natriuretic Peptidemediated Metamentioning

confidence: 99%

Natriuretic peptides in the control of lipid metabolism and insulin sensitivity

et al. 2017

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Natriuretic peptides have long been known for their cardiovascular function. However, a growing body of evidence emphasizes the role of natriuretic peptides in human substrate and energy metabolism, thereby connecting the heart with several insulin-sensitive organs like adipose tissue, skeletal muscle and liver. Obesity may be associated with an impaired regulation of the natriuretic peptide system, also indicated as a natriuretic handicap. Evidence points towards a contribution of this natriuretic handicap to the development of obesity, type 2 diabetes mellitus and cardiometabolic complications, although the causal relationship is not fully understood. Nevertheless, targeting the natriuretic peptide pathway may improve metabolic health in obesity and type 2 diabetes mellitus. This review will focus on current literature regarding the metabolic roles of natriuretic peptides with emphasis on lipid metabolism and insulin sensitivity. Furthermore, it will be discussed how exercise and lifestyle intervention may modulate the natriuretic peptide-related metabolic effects.

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Section: Lifestyle Interventions and Natriuretic Peptidemediated Metamentioning

confidence: 99%

Natriuretic peptides in the control of lipid metabolism and insulin sensitivity

et al. 2017

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“…Considering 304 that AT and systemic inflammation are associated with insulin resistance [74], this could be 305 one mechanism by which ANP preserves insulin sensitivity in humans. Two studies also 306 suggested that ANP enhances the secretion of the pro-insulin sensitizing adipokine normalize NPRC expression in white adipose tissue [93]. It was shown that the early phase 371 of weight loss induced by calorie restriction is associated with natriuresis, reduction in blood 372 pressure and a doubling of plasma ANP levels in overweight normotensive subjects [94].…”

Section: Insulin Sensitivity 288mentioning

confidence: 99%

Natriuretic peptide control of energy balance and glucose homeostasis

Coué

Moro

2016

Biochimie

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“…e cardiac natriuretic peptide system directly reduces renin and aldosterone secretion and antagonizes AngII and aldosterone effects on target cells [26]. A number of studies reported reduced levels of circulating natriuretic peptides in obese subjects with hypertension [29,30] and without hypertension [31][32][33]. We found that in obese hypertensive patients, the intake of glucose with NaCl was associated with a significant increase in serum Na and that obese hypertensive patients had higher serum Na and AngII compared with nonobese patients.…”

Section: Discussionmentioning

confidence: 58%

The Effects of Salt and Glucose Intake on Angiotensin II and Aldosterone in Obese and Nonobese Patients with Essential Hypertension

Alaagib

Sukkar²,

Kardash

2020

International Journal of Hypertension

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Background. e exact mechanisms for the development of essential hypertension are not known. Activation of the reninangiotensin-aldosterone system (RAAS) in adipose tissue may represent an important link between obesity and hypertension. is study investigates the effects of oral intake of glucose with and without NaCl on angiotensin II (AngII) and aldosterone in obese and nonobese patients with essential hypertension. Methods. Twenty newly diagnosed untreated essential hypertensive patients and 15 normotensive control subjects matched for age, gender, and BMI were studied. Participants fasted overnight (8-10 hrs), and then each subject took 75 gm glucose alone and with 3 gm NaCl, each dissolved in 250 ml. Subjects were monitored for 2 hours. Half hourly BP, plasma glucose (PG), serum Na + , K + , insulin, AngII, and aldosterone were measured. Subjects were classified into obese (BMI >30 Kg/m 2 ) (11 patients and 8 control) and nonobese (BMI <30 Kg/m 2 ) (9 patients and 7 control). Results. After intake of glucose with NaCl serum, AngII was significantly higher in obese hypertensive patients compared with nonobese patients (P � 0.016). Intake of glucose with NaCl resulted in a significantly higher serum Na in obese hypertensive patients compared with nonobese patients Na (P � 0.009). Serum aldosterone was significantly higher in obese patients (P � 0.03, after glucose; P � 0.003, after glucose with NaCl) and in nonobese patients (P � 0.000 and P � 0.000, respectively) compared with their respective normotensive control subjects. In obese and nonobese patients, intake of glucose and glucose with NaCl showed no significant change in the levels of serum AngII and aldosterone which was associated a significant increase in serum Na in obese patients (P � 0.03) and a highly significant reduction in serum K in nonobese patients (P � 0.001). Conclusion. Failure of suppression or inappropriate maintenance of secretion of AngII and aldosterone in both hypertensive groups by intake of glucose with NaCl may indicate a possible mechanism of essential hypertension.

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Differential response of the natriuretic peptide system to weight loss and exercise in overweight or obese patients

Cited by 36 publications

References 36 publications

Natriuretic peptides in the control of lipid metabolism and insulin sensitivity

Natriuretic peptides in the control of lipid metabolism and insulin sensitivity

Natriuretic peptide control of energy balance and glucose homeostasis

The Effects of Salt and Glucose Intake on Angiotensin II and Aldosterone in Obese and Nonobese Patients with Essential Hypertension

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