Differential tractography as a track-based biomarker for neuronal injury

Yeh, Fang‐Cheng; Zaydan, Islam M.; Suski, Valerie; Lacomis, David; Richardson, R. Mark; Maroon, Joseph C.; Barrios‐Martinez, Jessica

doi:10.1016/j.neuroimage.2019.116131

Cited by 93 publications

(106 citation statements)

References 30 publications

Supporting

Mentioning

105

Contrasting

Order By: Relevance

“…The diffusion data pre-processing was performed based on the DSI studio ( http://dsi-studio.labsolver.org ). The following steps were performed, DICOM raw data were reconstructed, motion and eddy current correction was performed, quality control routines were conducted (Yeh et al, 2019b ), b-table was checked by an automatic quality control routine to ensure its accuracy (Schilling et al, 2019 ). The diffusion data were reconstructed in the MNI space using q-space diffeomorphic reconstruction to obtain the spin distribution function (Yeh et al, 2010 ).…”

Section: Methodsmentioning

confidence: 99%

Disrupted Amygdala Connectivity Is Associated With Elevated Anxiety in Sensorineural Hearing Loss

et al. 2020

View full text Add to dashboard Cite

Background and Purpose: Hearing loss is associated with rising risks of emotional impairments, suggesting emotional processing networks might be involved in the neural plasticity after hearing loss. This study was conducted to explore how functional connectivity of the amygdala reconfigures in the auditory deprived brain and better understand the neural mechanisms underlying hearing loss-related emotional disturbances.Methods: In total, 38 chronic sensorineural hearing loss (SNHL) patients and 37 healthy controls were recruited for multimodal magnetic resonance imaging scanning and neuropsychological assessments. Voxel-wise functional connectivity (FC) maps of both the left and right amygdala were conducted and compared between the SNHL patients and healthy controls. The uncinate fasciculus (UF), an association fiber pathway, was reconstructed in both groups. The track number, mean track length, fractional anisotropy (FA) and mean diffusion values of the left and right UF were further quantified, respectively. Besides, Pearson's correlation analyses were conducted to investigate the relationship between the functional/structural abnormalities and the negative emotional states in SNHL patients.Results: The SNHL patients presented higher depressive and anxious levels compared to the healthy controls. Decreased FCs were detected between the amygdala and the auditory cortex, striatum, multimodal processing areas, and frontoparietal control areas in the SNHL patients. The amygdala was found to be structurally connected with several FC decreased regions through the UF. Moreover, the hypo-synchronization and the white matter impairment were both found to be associated with patients' elevated anxious status.Conclusions: These functional and structural findings depicted the reconfiguration of the amygdala in SNHL, which provided a new perspective toward the functional circuit mechanisms targeting the emotional impairments related to hearing loss.

show abstract

Section: Methodsmentioning

confidence: 99%

Disrupted Amygdala Connectivity Is Associated With Elevated Anxiety in Sensorineural Hearing Loss

et al. 2020

View full text Add to dashboard Cite

show abstract

“…We used differential tractography to track the anisotropy difference along WM tracts over time. This technique was developed to compare the dMRI scans of a single patient at different times by mapping the DTI data into a common space and tracing the connectivity alterations through all or specific WM fiber tracts (Yeh et al, 2019). By focusing on the FIGURE 2 | Longitudinal SWAP examinations and statistical analyses were done.…”

Section: Differential Tractographymentioning

confidence: 99%

Case Report: Chemotherapy Indication in a Case of Neurofibromatosis Type 1 Presenting Optic Pathway Glioma: A One-Year Clinical Case Study Using Differential Tractography Approach

Pajavand

Sharifi

Anvari

et al. 2021

Front. Hum. Neurosci.

View full text Add to dashboard Cite

Neurofibromatosis type 1 (NF1) is associated with peripheral and central nervous system tumors. It is noteworthy that the regions in which these tumors frequently arise are the optic pathways (OPs) and the brainstem. Thus, we decided to trace the procedure of diffusion Magnetic Resonance Imaging (dMRI) alterations along with Short-Wavelength Automated Perimetry (SWAP) examinations of the OPs after surgery and chemotherapy over 1 year, which enabled us to evaluate chemotherapy's efficacy in an NF1 patient with an OP tumor. In this study, a 25-year-old woman with NF1 and left optic radiation (OR) glioma underwent surgery to remove the glioma. Immunohistochemistry (IHC) revealed a Pilocytic Astrocytoma (PA) WHO grade I. Post-operation chemotherapy done using nine treatment cycles of administering Temozolomide (TMZ) for 5 days every 4 weeks. Applying the region of interest (ROI) differential tractography method and SWAP four times every 3 months allowed us to follow the patient's visual acuity alterations longitudinally. The differential deterministic tractography method and statistical analyses enabled us to discover the white matter (WM) tracts anisotropy alterations over time. Furthermore, statistical analyses on the SWAP results along time illustrated possible alterations in visual acuity. Then, we could compare and associate the findings with the SWAP examinations and patient symptoms longitudinally. Statistical analyses of SWAP tests revealed a significant improvement in visual fields, and longitudinal differential tractography showed myelination and dense axonal packing in the left OR after 1 year of treatment. In this study, we examined an old hypothesis suggesting that chemotherapy is more effective than radiotherapy for NF1 patients with OP gliomas (OPGs) because of the radiation side effects on the visual field, cognition, and cerebrovascular complications. Our longitudinal clinical case study involving dMRI and SWAP on a single NF1-OPG patient showed that chemotherapy did not suppress the OP myelination over time. However, it should be noted that this is a clinical case study, and, therefore, the generalization of results is limited. Future investigations might focus on genetic-based imaging, particularly in more cases. Further, meta-analyses are recommended for giving a proper Field Of View (FOV) to researchers as a subtle clue regarding precision medicine.

show abstract

“…Standardized text describing the workflow is automatically generated, including citations for any software or methods used; see Supplementary Figure S1 and Supplementary Note 2.1. In addition, each preprocessed Diffusion-Weighted Image (DWI) series is accompanied by a quality control (QC) text file that describes the number of dropped slices, head motion summary measures, image dimensions before and after preprocessing, and a useful summary measure of data quality --the neighboring DWI correlation (NDC) 16 .…”

Section: Qsiprep Provides Intuitive Visual Reports and Automated Measmentioning

confidence: 99%

QSIPrep: An integrative platform for preprocessing and reconstructing diffusion MRI

Cieslak

Cook

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Diffusion-weighted magnetic resonance imaging (dMRI) has become the primary method for non-invasively studying the organization of white matter in the human brain. While many dMRI acquisition sequences have been developed, they all sample q-space in order to characterize water diffusion. Numerous software platforms have been developed for processing dMRI data, but most work on only a subset of sampling schemes or implement only parts of the processing workflow. Reproducible research and comparisons across dMRI methods are hindered by incompatible software, diverse file formats, and inconsistent naming conventions. Here we introduce QSIPrep, an integrative software platform for the processing of diffusion images that is compatible with nearly all dMRI sampling schemes. Drawing upon a diverse set of software suites to capitalize upon their complementary strengths, QSIPrep automatically applies best practices for dMRI preprocessing, including denoising, distortion correction, head motion correction, coregistration, and spatial normalization. Throughout, QSIPrep provides both visual and quantitative measures of data quality as well as “glass-box” methods reporting. Taken together, these features facilitate easy implementation of best practices for processing of diffusion images while simultaneously ensuring reproducibility.

show abstract

Differential tractography as a track-based biomarker for neuronal injury

Cited by 93 publications

References 30 publications

Disrupted Amygdala Connectivity Is Associated With Elevated Anxiety in Sensorineural Hearing Loss

Disrupted Amygdala Connectivity Is Associated With Elevated Anxiety in Sensorineural Hearing Loss

Case Report: Chemotherapy Indication in a Case of Neurofibromatosis Type 1 Presenting Optic Pathway Glioma: A One-Year Clinical Case Study Using Differential Tractography Approach

QSIPrep: An integrative platform for preprocessing and reconstructing diffusion MRI

Contact Info

Product

Resources

About