Differential Verbal Fluency Deficits in the Preclinical Stages of Alzheimer's Disease and Vascular Dementia

Jones, Sari; Laukka, Erika J.; Bäckman, Lars

doi:10.1016/s0010-9452(08)70361-7

Cited by 76 publications

(55 citation statements)

References 175 publications

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“…In those studies that have found preclinical cognitive performance to be similar in VaD and AD, it must be acknowledged that the diagnostic outcomes are also similar (ie, both VaD and AD require memory deficits). 9,10,12,13 Although we did not replicate the findings of Jones et al 14 of poorer semantic category fluency in preclinical AD relative to preclinical VaD, we note that VCI is a heterogeneous condition and that different forms may well present with different prodromal cognitive profiles. For example, people with VaD who have significant subcortical pathology may be more impaired on tests of executive functioning and visual construction, whereas those with little subcortical pathology may be more impaired on tests of language and memory.…”

Section: Resultsmentioning

confidence: 53%

“…Other groups have also shown that reductions in memory, as part of a more global pattern of impairment, precede diagnoses of both VaD and AD by up to 4 years. 9 -13 Although few differences in the preclinical cognitive profiles of these 2 conditions have been observed, 9,10,12, 13 Jones et al 14 found that semantic category fluency was more impaired in preclinical AD, whereas deficits in letter category fluency were present in both preclinical AD and VaD.…”

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confidence: 99%

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Preclinical Vascular Cognitive Impairment and Alzheimer Disease

Ingles

Boulton

Fisk

et al. 2007

Stroke

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Background and Purpose-Neuropsychological changes that precede a diagnosis of vascular cognitive impairment (VCI) and the differences between preclinical VCI and Alzheimer disease (AD) are not well understood. We compared the neuropsychological performances of people with incident VCI, incident AD, and no cognitive impairment (NCI) 5 years before their clinical diagnoses. Methods-The Canadian Study of Health and Aging is a prospective, cohort study of 10 263 randomly selected persons age 65 years or older. We studied 332 individuals who had completed a battery of neuropsychological tests and were diagnosed with NCI at baseline. After 5 years, 41 were diagnosed with VCI, 25 with AD, and 266 with NCI. Results-At baseline, the incident-VCI group performed worse on a wide range of neuropsychological tests compared with the NCI group. A test of abstract reasoning was selectively low in the incident-VCI group, relative to both the incident-AD and NCI groups. The incident-AD group performed worse at baseline on memory tests compared with incident-VCI and NCI groups. Conclusions-This study suggests a preclinical phase may exist in VCI that differs from that in AD. Neuropsychological measures may aid the design of preventive strategies for VCI.

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Section: Resultsmentioning

confidence: 53%

mentioning

confidence: 99%

Preclinical Vascular Cognitive Impairment and Alzheimer Disease

Ingles

Boulton

Fisk

et al. 2007

Stroke

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“…However, there is no consensus in the literature about the performance in category fluency as being better or worse in VaD than in AD, with some authors reporting no differences 18 or even a reverse pattern, i.e., worse performance on this task in AD when compared to VaD 19 .…”

Section: Resultsmentioning

confidence: 99%

Limitations in differentiating vascular dementia from Alzheimer's disease with brief cognitive tests

Matioli

Caramelli

2010

Arq. Neuro-Psiquiatr.

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Objective: To investigate the diagnostic value of brief cognitive tests in differentiating vascular dementia (VaD) from Alzheimer's disease (AD). Method: Fifteen patients with mild VaD, 15 patients with mild probable AD and 30 healthy controls, matched for age, education and dementia severity, were submitted to the following cognitive tests: clock drawing (free drawing and copy), category and letter fluency, delayed recall test of figures and the EXIT 25 battery. Results: VaD patients performed worse than AD patients in category fluency (p=0.014), letter fluency (p=0.043) and CLOX 2 (p=0.023), while AD cases performed worse than VaD patients in delayed recall (p=0.013). However, ROC curves for these tests displayed low sensitivity and specificity for the differential diagnosis between VaD and AD. Conclusion: Although the performance of VaD and AD patients was significantly different in some cognitive tests, the value of such instruments in differentiating VaD from AD proved to be very limited. Key words: Alzheimer's disease, vascular dementia, clock drawing test, delayed recall, diagnosis, EXIT25, neuropsychological tests, verbal fluency.Limitações em diferenciar demência vascular de doença de Alzheimer através de testes cognitivos breves RESUMO Objetivo: Investigar o valor diagnóstico de testes cognitivos breves na diferenciação de demência vascular (DV) e doença de Alzheimer (DA). Método: Quinze pacientes com DV, 15 com DA provável e 30 controles saudáveis, pareados em relação à idade, escolaridade e gravidade da demência, foram submetidos aos seguintes testes: desenho do relógio espontâneo e cópia, fluência verbal semântica e fonêmica, teste de evocação de memória de figuras e a bateria EXIT25. Resultados: Pacientes com DV apresentaram pior desempenho na fluência verbal semântica (p=0,014), fonêmica (p=0,043), e no CLOX 2 (p=0,023). O grupo com DA obteve pior desempenho no teste de evocação tardia (p=0,013). As curvas ROC aplicadas a esses testes mostraram baixa sensibilidade e especificidade para o diagnóstico diferencial entre DV e DA. Conclusão: Embora o desempenho dos pacientes tenha sido diferente em alguns testes, o valor desses instrumentos para o diagnóstico diferencial entre DV e DA parece ser muito limitado. Palavras-chave: doença de Alzheimer, demência vascular, teste do desenho do relógio, memória de evocação, diagnóstico, EXIT25, testes neuropsicológicos, fluência verbal.

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“…3) језичке способности; на примјер: Boston naming test -BNT (Kaplan, Goodglass, & Weintraub, 1983), Boston diagnostic aphasia examination -BDAE (Goodglass& ; разноврсни задаци вербалне флуентности, нарочито семантичке (Araujo et al, 2011;Gomez& White, 2006;Henry, Crawford, & Phillips, 2004;Jones, Laukka, & Bäckman, 2006) (Cummings et al, 1994), Geriatric Depression Scale -GDS (Yesavage, et al, 1983), Beck Anxiety Inventory -BAI (Beck & Steer, 1990), Beck Depression Inventory -BDI (Beck, Ward, Mendelson, Mock, &Erbaugh, 1961).…”

Section: Rivermead Behavioural Memory Test -Rbmtunclassified

Улога Психолога У Превенцији, Дијагнози И Третману Алцхајмерове Болести

Радукић¹,

Димитријевић²,

Суботић³

2016

RAD

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У раду су приказани послови које може да обавља психолог који ради с обољелим од Алцхајмерове болести. Детаљније су обрађени задаци у којима је улога психолога нарочито значајна: (а) проучавање Алцхајмерове болести, израда и примјена дијагностичких инструмената, (б) рад с обољелим лицима у почетним стадијумима болести, (ц) рад са породицама обољелих, (д) превенција. Приказ је направљен на основу рецентне литературе и личне комуникације са иностраним експертима. Посебно је истакнута превентивна улога коју могу имати психолози који не раде директно с обољелим особама (нпр. психолози који раде у школама).

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Differential Verbal Fluency Deficits in the Preclinical Stages of Alzheimer's Disease and Vascular Dementia

Cited by 76 publications

References 175 publications

Preclinical Vascular Cognitive Impairment and Alzheimer Disease

Preclinical Vascular Cognitive Impairment and Alzheimer Disease

Limitations in differentiating vascular dementia from Alzheimer's disease with brief cognitive tests

Улога Психолога У Превенцији, Дијагнози И Третману Алцхајмерове Болести

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