Differential viral propagation and induction of apoptosis by grouper iridovirus (GIV) in cell lines from three non-host species

Giant seaperch iridovirus infection upregulates Bas and Bak expression, leading to apoptotic death of fish cells

“…Most iridoviruses, including frog virus 3 (FV3), STIV, Rana grylio virus (RGV), red sea bream iridovirus (RSIV), lymphocystis disease virus (LCDV), and Chilo iridescent virus (CIV, induce typical apoptosis [16,17,19e23]. In contrast, several ranavirus isolates, including Singapore grouper iridovirus (SGIV) and grouper iridovirus (GIV), trigger non-apoptotic programmed cell death in grouper cells [16,17].…”

In vitro antiviral efficacy of moroxydine hydrochloride and ribavirin against grass carp reovirus and giant salamander iridovirus

“…The emergence of deadly iridovirus diseases in aquatic animals has led to a growing interest in the mechanisms of iridovirus-induced host cell death (Imajoh et al 2004, Pham et al 2012, Chen et al 2016. Most iridoviruses induce typical apoptosis or trigger non-apoptotic-programmed cell death in fish cells (Gibson-Kueh et al 2003, Chen et al 2016.…”

Ranavirus Host Immunity and Immune Evasion

“…This notion has recently been substantiated with Grouper iridovirus (GIV). Replication-defi cient UV-inactivated GIV induced apoptosis in two of the three infected cell lines (Pham et al 2012 ). Similarly, heat-and UV-inactivated FV3 elicits FHM cell apoptosis and inhibits host RNA and protein synthesis (Chinchar et al 2003 ;Raghow and Granoff 1979 ).…”