2019
DOI: 10.1111/vco.12458
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Differentially expressed microRNAs, including a large microRNA cluster on chromosome 24, are associated with equine sarcoid and squamous cell carcinoma

Abstract: The aim of this study was to investigate microRNA (miRNA) differential expression in the two most common equine skin tumours, equine sarcoid (ES) and squamous cell carcinoma (SCC), and its potential influence on the tumour microenvironment at post‐transcriptional level. We investigated miRNA fingerprints in four subgroups: mild (ESM) and aggressive (ESA) ES and ocular SCC (oSCC) and genital SCC (gSCC). Three tumours and three control samples were included in each of the four subgroups. Following next generatio… Show more

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Cited by 13 publications
(21 citation statements)
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References 57 publications
(126 reference statements)
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“…However, that possibility requires further investigation 99 . Changes in the expression level of the identified equine miRNA cluster were also observed in a recent study by Bogedale et al 97 . When analysing a group of mild and aggressive equine sarcoids, they found increased expression levels of this microRNA cluster in the mild group, suggesting that overexpression of these miRNAs at tumour tissue level may inhibit tumour growth and result in less aggressive sarcoid lesions.…”
Section: Epigenetic Changes In Equine Sarcoidssupporting
confidence: 56%
“…However, that possibility requires further investigation 99 . Changes in the expression level of the identified equine miRNA cluster were also observed in a recent study by Bogedale et al 97 . When analysing a group of mild and aggressive equine sarcoids, they found increased expression levels of this microRNA cluster in the mild group, suggesting that overexpression of these miRNAs at tumour tissue level may inhibit tumour growth and result in less aggressive sarcoid lesions.…”
Section: Epigenetic Changes In Equine Sarcoidssupporting
confidence: 56%
“…MicroRNAs (miRNAs) are a group of small noncoding RNAs of 19 to 25 nucleotides in length (13). These molecules mediate mRNA degradation or translational inhibition by directly binding to the complementary sequences within the 3= untranslated region (3=-UTR) of these mRNAs (14). A variety of cellular and physiological processes, including cell proliferation, differentiation, apoptosis, and tumor metastasis, are regulated by posttranscriptional processing of miRNAs (15).…”
mentioning
confidence: 99%
“…The oncogenesis of equine sarcoids also involves loss of expression of the Fragile Histidine Triad (FHIT) and of the O 6 -methylguanine-DNA methyltransferase (MGMT) tumor suppressor proteins [28,29]. Recent studies have evaluated the role of small non-coding RNAs that regulate gene expression (microRNAs) in the development of sarcoids, and the role of aberrant methylation (S100A14 gene) is under research [30][31][32][33][34].…”
Section: Etiopathogenesis Of the Equine Sarcoid 21 Bovine Papillomavmentioning
confidence: 99%