Differentially Expressed miRNAs in Ulcerative Colitis and Crohn’s Disease

Yarani, Reza; Shojaeian, Ali; Palasca, Oana; Doncheva, Nadezhda T.; Jensen, Lars Juhl; Gorodkin, Jan; Pociot, Flemming

doi:10.3389/fimmu.2022.865777

Cited by 30 publications

(13 citation statements)

References 188 publications

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“…It is upregulated in neutrophils and monocytes and acts as a controller of NLRP3 inflammasome activity, regulating the intestine inflammatory process by affecting IL-1β production ( Neudecker et al, 2017 ). It has also been shown that miR-223 mediates the cross-talk between the intestinal barrier and the IL-23 pathway by targeting CLDN8, a claudin protein that constitutes the backbone of the intestinal barrier ( Wang et al, 2016a ; Yarani et al, 2022 ). miR-223 has also been used as a biomarker in IBD ( Wang et al, 2016b ; Yarani et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…It has also been shown that miR-223 mediates the cross-talk between the intestinal barrier and the IL-23 pathway by targeting CLDN8, a claudin protein that constitutes the backbone of the intestinal barrier ( Wang et al, 2016a ; Yarani et al, 2022 ). miR-223 has also been used as a biomarker in IBD ( Wang et al, 2016b ; Yarani et al, 2022 ). Thus, the evidence suggests its proinflammatory role and highlights its potential as an RNA biomarker that seems to be conserved between different species.…”

Section: Discussionmentioning

confidence: 99%

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Cross-species high-resolution transcriptome profiling suggests biomarkers and therapeutic targets for ulcerative colitis

Yarani

Palasca

Doncheva

et al. 2023

Front. Mol. Biosci.

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Background: Ulcerative colitis (UC) is a disorder with unknown etiology, and animal models play an essential role in studying its molecular pathophysiology. Here, we aim to identify common conserved pathological UC-related gene expression signatures between humans and mice that can be used as treatment targets and/or biomarker candidates.Methods: To identify differentially regulated protein-coding genes and non-coding RNAs, we sequenced total RNA from the colon and blood of the most widely used dextran sodium sulfate Ulcerative colitis mouse. By combining this with public human Ulcerative colitis data, we investigated conserved gene expression signatures and pathways/biological processes through which these genes may contribute to disease development/progression.Results: Cross-species integration of human and mouse Ulcerative colitis data resulted in the identification of 1442 genes that were significantly differentially regulated in the same direction in the colon and 157 in blood. Of these, 51 genes showed consistent differential regulation in the colon and blood. Less known genes with importance in disease pathogenesis, including SPI1, FPR2, TYROBP, CKAP4, MCEMP1, ADGRG3, SLC11A1, and SELPLG, were identified through network centrality ranking and validated in independent human and mouse cohorts.Conclusion: The identified Ulcerative colitis conserved transcriptional signatures aid in the disease phenotyping and future treatment decisions, drug discovery, and clinical trial design.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cross-species high-resolution transcriptome profiling suggests biomarkers and therapeutic targets for ulcerative colitis

Yarani

Palasca

Doncheva

et al. 2023

Front. Mol. Biosci.

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“…The study showed that ASCA positivity had been found in 75% of CD patients and 27% of UC patients, and the p-ANCA was detected in 72% of UC patients and 16% of CD patients, so ASCA and p-ANCA could be used to identify UC and CD ( 43 ). Other biomarkers such as microRNA could also be used for the identification of UC and CD ( 60 ). Fecal biomarkers, including fecal calprotectin, were increasingly used as screening tests and assessing disease activity in IBD.…”

Section: Discussionmentioning

confidence: 99%

Research hotspot and trend analysis in the diagnosis of inflammatory bowel disease: A machine learning bibliometric analysis from 2012 to 2021

Liu

Zhang

et al. 2022

Front. Immunol.

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AimsThis study aimed to conduct a bibliometric analysis of the relevant literature on the diagnosis of inflammatory bowel disease (IBD), and show its current status, hot spots, and development trends.MethodsThe literature on IBD diagnosis was acquired from the Science Citation Index Expanded of the Web of Science Core Collection. Co-occurrence and cooperation relationship analysis of authors, institutions, countries, journals, references, and keywords in the literature were carried out through CiteSpace software and the Online Analysis platform of Literature Metrology. At the same time, the relevant knowledge maps were drawn, and the keywords cluster analysis and emergence analysis were performed.Results14,742 related articles were included, showing that the number of articles in this field has increased in recent years. The results showed that PEYRIN-BIROULET L from the University Hospital of Nancy-Brabois was the author with the most cumulative number of articles. The institution with the most articles was Mayo Clin, and the United States was far ahead in the article output and had a dominant role. Keywords analysis showed that there was a total of 818 keywords, which were mainly focused on the research of related diseases caused or coexisted by IBD, such as colorectal cancer and autoimmune diseases, and the diagnosis and treatment methods of IBD. Emerging analysis showed that future research hotspots and trends might be the treatment of IBD and precision medicine.ConclusionThis research was the first bibliometric analysis of publications in the field of IBD diagnosis using visualization software and data information mining, and obtained the current status, hotspots, and development of this field. The future research hotspot might be the precision medicine of IBD, and the mechanism needed to be explored in depth to provide a theoretical basis for its clinical application.

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“…To our knowledge, the incidence of a lower amount of miR-26a in mouse breastmilk has been reported with physiological consequences in the adipocyte compartment [51]. Yarani et al (2022) have explored using meta-analysis the role of miRNAs in ulcerative colitis and Crohn's Disease, underlining that the miR-375-3p is downregulated during the development of these inflammatory diseases [52]. Oral supplementation with miR-375-3p could open new therapeutic avenues for curing these diseases.…”

Section: Discussionmentioning

confidence: 99%

Oral Delivery of miR-320-3p with Lipidic Aminoglycoside Derivatives at Mid-Lactation Alters miR-320-3p Endogenous Levels in the Gut and Brain of Adult Rats According to Early or Regular Weaning

Tavares

Torres

Dréan

et al. 2022

IJMS

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To investigate if the artificial delivery of microRNAs naturally present in the breastmilk can impact the gut and brain of young rats according to weaning. Animals from a new transgenic rat line expressing the green-fluorescent protein in the endocrine lineage (cholecystokinin expressing cells) received a single oral bolus of miR-320-3p or miR-375-3p embedded in DiOleyl-Succinyl-Paromomycin (DOSP) on D-12. The pups were weaned early (D-15), or regularly (D-30). The expression of relevant miRNA, mRNAs, chromatin complexes, and duodenal cell density were assessed at 8 h post-inoculation and on D-45. The miR-320-3p/DOSP induced immediate effects on H3K4me3 chromatin complexes with polr3d promoter (p < 0.05). On regular weaning, on D-45, miR-320-3p and 375-3p were found to be downregulated in the stomach and upregulated in the hypothalamus (p < 0.001), whereas miR-320-3p was upregulated in the duodenum. After early weaning, miR-320-3p and miR-375-3p were downregulated in the stomach and the duodenum, but upregulated in the hypothalamus and the hippocampus. Combination of miR-320-3p/DOSP with early weaning enhanced miR-320-3p and chromogranin A expression in the duodenum. In the female brain stem, miR-320-3p, miR-504, and miR-16-5p levels were all upregulated. Investigating the oral miRNA-320-3p loads in the duodenal cell lineage paved the way for designing new therapeutics to avoid unexpected long-term impacts on the brain.

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Differentially Expressed miRNAs in Ulcerative Colitis and Crohn’s Disease

Cited by 30 publications

References 188 publications

Cross-species high-resolution transcriptome profiling suggests biomarkers and therapeutic targets for ulcerative colitis

Cross-species high-resolution transcriptome profiling suggests biomarkers and therapeutic targets for ulcerative colitis

Research hotspot and trend analysis in the diagnosis of inflammatory bowel disease: A machine learning bibliometric analysis from 2012 to 2021

Oral Delivery of miR-320-3p with Lipidic Aminoglycoside Derivatives at Mid-Lactation Alters miR-320-3p Endogenous Levels in the Gut and Brain of Adult Rats According to Early or Regular Weaning

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