Differentially expressed non-coding RNAs and their regulatory networks in liver cancer

Moldogazieva, Nurbubu T.; Zavadskiy, Sergey P.; Astakhov, Dmitry V.; Sologova, Susanna S.; Margaryan, Arus G.; Safrygina, Anastasiya A.; Smolyarchuk, Elena A.

doi:10.1016/j.heliyon.2023.e19223

Cited by 7 publications

(3 citation statements)

References 151 publications

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“…The regulatory roles of circRNAs have been investigated in hepatocarcinogenesis and the development of HCC [ 12 ]. It is noteworthy that dysregulated circRNA-miRNA-mRNA axis plays important roles in HCC and has been widely discussed [ 13 ]. For example, circRNA-5692 hampers the development of HCC by acting as a sponge for miR-328-5p to up-regulate DAB2IP expression level [ 14 ]; circRNA-104718 modulates miR-218-5p and TXNDC5 via competing endogenous RNA (ceRNA) mode, thus facilitating HCC progression [ 15 ]; hsa_circ_0091570 as a ceRNA sequesters miR-1307 to hinder HCC progression [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

CircGNAO1 strengthens its host gene GNAO1 expression for suppression of hepatocarcinogenesis

He,

Zhang,

et al. 2024

Heliyon

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Section: Introductionmentioning

confidence: 99%

CircGNAO1 strengthens its host gene GNAO1 expression for suppression of hepatocarcinogenesis

He,

Zhang,

et al. 2024

Heliyon

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“…An abundance of research has shown that lncRNAs participate in some biological processes of HCC, including proliferation, invasion, ferroptosis and metastasis, etc. ( 9 , 10 ). For instance, one study shows that HCC ferroptosis associative lncRNA (HEPFAL) is shown to mediate the ubiquitination of SLC7A11 to promote ferroptosis in HCC ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Suppression of hepatocellular carcinoma progression by long noncoding RNA apolipoprotein C1 pseudogene via the regulation of the microRNA-106b-PTEN axis

Qian,

Chen,

Chen

et al. 2023

Transl Cancer Res

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Background Numerous researches have reported that long noncoding RNAs (lncRNAs) participate in tumor development and progression. LncRNA apolipoprotein C-I pseudogene 1 ( APOC1P1 ), a pseudogene located in 19q13.2 between apolipoprotein C-I and apolipoprotein C-IV, is involved in a variety of diseases. However, the role of lncRNA APOC1P1 in hepatocellular carcinoma (HCC) remains unknown. Methods Quantitative polymerase chain reaction (qPCR) was performed to examine the expression of APOC1P1 , miR-106b, and PTEN (phosphatase and TENsin homolog deleted on chromosome 10) in HCC tissues, adjacent normal tissues, and specific cell lines (LO2, Bel-7407, HCCLM3, MHCC-97H, Hep G2, and Huh-7). Upregulation of APOC1P1 and downregulation of miR-106b were conducted via application of vector transfection and microRNA (miRNA) inhibitor. Bioinformatics analysis and luciferase reporter assay were used to verify the binding sites of APOC1P1 , miR-106b, and PTEN. Cell proliferation and invasion were determined with Cell Counting Kit-8 (CCK-8) and Transwell experiments. Subcellular location analysis was used to determine the distribution of APOC1P1 in cells, and Western blotting was used to detect the expression of PTEN. Results It was found that the expressions of APOC1P1 and PTEN were downregulated, while that of miR-106b was upregulated in HCC tissues and cells. Subcellular location analysis showed that APOC1P1 was localized in cytoplasm and competitively bound to miR-106b. APOC1P1 overexpression and miR-106b inhibition suppressed HCC cell proliferation and invasion. qPCR indicated the negative correlation between APOC1P1 expression and miR-106b expression in HCC tissues and a positive correlation between APOC1P1 and PTEN. Conclusions Our findings suggested that the lncRNA APOC1P1 inhibits HCC progression by competitively binding to miR-106b, leading to elevated PTEN expression, inhibiting cell proliferation and invasion in HCC cells. These results provide new insights into the diagnosis and therapy of HCC.

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“… 14 LncRNAs have been proven to play crucial roles in nearly all stages of HCC, including cell proliferation, differentiation, invasion, metastasis and drug sensitivity. 15–19 Given their vital functions, the expression of specific dysregulated lncRNAs has the potential to serve as diagnostic and therapeutic biomarkers. 20 , 21 Therefore, lncRNA-based signature could be harnessed to influence therapeutic strategy of HCC.…”

mentioning

confidence: 99%

New HCC Subtypes Based on CD8 Tex-Related lncRNA Signature Could Predict Prognosis, Immunological and Drug Sensitivity Characteristics of Hepatocellular Carcinoma

Ge,

Tao,

Zhang

et al. 2024

JHC

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Differentially expressed non-coding RNAs and their regulatory networks in liver cancer

Cited by 7 publications

References 151 publications

CircGNAO1 strengthens its host gene GNAO1 expression for suppression of hepatocarcinogenesis

CircGNAO1 strengthens its host gene GNAO1 expression for suppression of hepatocarcinogenesis

Suppression of hepatocellular carcinoma progression by long noncoding RNA apolipoprotein C1 pseudogene via the regulation of the microRNA-106b-PTEN axis

New HCC Subtypes Based on CD8 Tex-Related lncRNA Signature Could Predict Prognosis, Immunological and Drug Sensitivity Characteristics of Hepatocellular Carcinoma

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