Differentiated approach to the choice of PPI in a patient with GERD in the practice of an outpatient (with a clinical case)

Abstract

In recent years, functional disorders of the gastrointestinal tract (GIT) are quite common. The most significant functional disorders are functional dyspepsia (FD), which is widespread in the population. In addition, in the clinical practice of outpatient doctors, the proportion of combined variants or overlap of several types of functional disorders or a combination of functional disorders with organic pathology has increased. So, according to systematic reviews, the combined course of gastroesophageal reflux disease (GERD) and FD occurs in at least one third of patients. At the same time, the combined functional pathology of the gastrointestinal tract changes the clinical picture of GERD, which complicates differential diagnosis, leads to inadequate and multiple prescription of drugs and often low effectiveness of the prescribed therapy. All this negatively affects the quality of life of patients. The tactics of managing patients with the combined course of GERD and FD sometimes presents certain difficulties, since there are no available recommendations for pathogenetic therapy and preventive measures. To date, possible links in the pathogenesis of both GERD and FD have been studied and described, which predetermine certain approaches to the treatment of various variants of these two diseases. Drug therapy for GERD includes the appointment of proton pump inhibitors (PPIs), antireflux drugs. In FD therapy, prokinetics and/or PPIs are effective. A rational approach in the treatment of the intersection of GERD and FD is the appointment of a drug with a dual mechanism of action, which contains both a prokinetic and a PPI. An example of this approach is the appointment of omeprazole and domperidone. The use of this drug is presented in a clinical case.

Evaluation of Prescription of Cases of Gerd Acid Disorders in Patients at Kasatria Public Health Center, Pematang Siantar City

“…In one study, administration of a single dose of intravenous omeprazole to healthy subjects showed inhibition of the metabolism of diazepam and its derivatives. Omeprazole decreases clearance and prolongs the elimination halflife of diazepam and its derivatives [10]. In other words, Omeprazole can increase the level of diazepam in the blood, which means it increases the effectiveness of the diazepam.…”