Differentiating antidepressants of the future: Efficacy and safety

Rosenzweig‐Lipson, Sharon; Beyer, Chad E.; Hughes, Zoë A.; Khawaja, Xavier; Rajarao, S. Johannes R.; Malberg, Jessica E.; Rahman, Zia Ur; Ring, Robert H.; Schechter, Lee E.

doi:10.1016/j.pharmthera.2006.07.002

Cited by 159 publications

(92 citation statements)

References 213 publications

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“…Entre os ANG, a mirtazapina parece se associar a um maior ganho de peso a longo prazo, enquanto que a venlafaxina e a bupropiona parecem ser neutros no ganho de peso 35 .…”

Section: Antidepressivos De Classes Diferentesunclassified

“…Os amplos intervalos de dosagem dependeram do princípio ativo de cada antidepressivo da mesma classe e da posologia definida para tal. Na prática clínica, a dosagem terapêutica também apresenta variações semelhantes no tratamento agudo 35 e há divergências entre os autores quanto às doses de manutenção 24,27 . Estes e demais aspectos analisados anteriormente apontam para a multifatoriedade do efeito dos antidepressivos na mudança de peso corporal e as dificuldades ainda existentes em obter uma conclusão definitiva sobre esta importante questão 35 .…”

Section: Antidepressivos De Classes Diferentesunclassified

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Antidepressivos e alterações no peso corporal

et al. 2008

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A depressão é uma doença que pode levar a mudanças no peso, influenciadas por fatores específicos da doença, como alterações no apetite e na atividade física, ou pelos antidepressivos. Este artigo objetiva analisar os estudos que descrevem os efeitos dos antidepressivos em alterações do peso corporal. Realizou-se uma pesquisa nas bases de dados Medline, Lilacs e Cochrane, utilizando as palavras chaves "antidepressivo" e "peso". Foram selecionados os estudos que analisaram o tema em pacientes depressivos, priorizando-se aqueles relacionados às drogas mais utilizadas nos serviços de saúde no Brasil. A análise dos estudos indicou que a mudança de peso atribuída ao tratamento com antidepressivos apresenta resultados ainda controversos, sendo influenciada por fatores como o tempo de uso e a dosagem do medicamento, estudos com poder limitado, entre outros. Assim, estudos com maior poder, tendo como foco a ação das drogas antidepressivas nas alterações do peso corporal em pacientes depressivos, ainda são necessários. Termos de indexação:Antidepressivos. Ganho/Perda de peso. Peso corporal. A B S T R A C T Depression is a disorder that may affect patient's weight because of specific factors of the disease, such as changes in appetite and

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“…Entre os ANG, a mirtazapina parece se associar a um maior ganho de peso a longo prazo, enquanto que a venlafaxina e a bupropiona parecem ser neutros no ganho de peso 35 .…”

Section: Antidepressivos De Classes Diferentesunclassified

Antidepressivos e alterações no peso corporal

et al. 2008

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“…However,the traditional antidepressantsdrugs are available but have some side effects such as, relapse, delayed onset of action, sexual dysfunction, weight gain, cardiovascular and gastrointestinal complications etc 11 .…”

Section: Introductionmentioning

confidence: 99%

Effect of Oyster Mushroom on Kidney in Stress Induced Depressed Rats

Jahan¹,

Akhter

Sultana

2017

J Bangladesh Soc Physiol

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Background: Depression is associated with stressful condition which may cause kidney damage. Oyster mushroom (plurotus florida) may have free radical scavenging activity thereby can be used for the prevention and treatment for kidney damage. Objective: to observe the effect of oyster mushroom (plurotus florida) on kidney in restraint stress induced depressed rats. Methods: This experimental study was conducted from July 2012 to June 2013 in the Department of Physiology, Sir Salimullah Medical College( SSMC), Mitford, Dhaka. Thirty Wister albino male rats, aged 90 to 100 days, weighing 150 to 180g (initial body weight) were used in the present study. Then they were divided into Group I (Control group, without mushroom n=20) and Group II (Experimental group, depressed rats supplemented with mushroom n=10). Control group without mushroom again subdivided into Group Ia,( baseline control n=10) and Group Ib (depressed control n=10) . All groups of animals were received basal diet for 28 consecutive days started from the 1 st day of the study period. Group Ib (depressed control) and group II (depressed mushroom supplemented) were housed under controlled condition in rat immobilizer (made up of steel wire, measuring 9´´ x 2.75´´ of light weight) for 6 hour/day for 28 days for the development of stress induced depression. In addition, only group II received oyster mushroom extract (200 mg/kg body weight, orally) for the same period. One rat of Group Ib (depressed control) was expired after 10 days for unknown cause. All 29 rats were sacrificed on day 30. Then blood sample and kidneys specimen were collected. Initial (initial bw ) and final body weights (final bw) were measured. Then estimation of blood glucose and serum urea levels were done by standard laboratory technique. Histology of kidney was done by standard laboratory procedure. Statistical analysis was done by using SPSS windows Version -16. One way ANOVA and Bonferroni tests were done as applicable. Results: In this study blood glucose level and serum urea level was significantly higher and abnormal histological structure was found in stress induced depressed rats. After taking mushroom extract for 28 days all the parameters were improved. Conclusion: From this study it can be concluded that oyster mushroom(Pleurotus florida) which is excellent edible and nutritious, may have renoprotective effect.

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“…2 The delayed onset of action of anti depressants and their adverse effectsrenders it necessary to find newer and safer therapeutic agents which would complement the existing treatment modalities. 3 Therefore, it is worthwhile to explore the utility of traditional medicines for the treatment of various depressive disorders. Costus speciosus (CS) rhizome has been proven to show anti diabetic, anti dyslipidemic, 4 hepatoprotective, 5 adaptogenic, 6 anti bacterial, 7 anti fertility, 8 anti inflammatory, anti pyretic, 9 and estrogenic 10 activity.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Costus speciosus in Experimental Models of Depression in Albino Mice

Rather¹,

Nateshprabhu

et al. 2016

Phcogj

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Introduction: Despite theavailability of numerous antidepressant drugs the therapy of depression is far from satisfactory. Two of the many reasons for this are the delay in onset of effect and the adverse effects associated with most of the antidepressants. Costus speciosus rhizome has shown adaptogenic activity. Objective: To evaluate the antidepressant activity of50% aqueous-ethanol extract of Costus speciosus (CS) leaves in experimental models of depression. Materials and Methods: Male albino mice were randomly assigned to five groups of six each. We studied three doses of the leaf extract (100, 200 and 400 mg/kg) on two models of depression -forced swim test and tail suspension test. Imipramine was used as the standard control. Both acute and chronic effects were studied. Drugs (test drug, standard control and vehicle) were administeredorally, one hour before the experiment in the acute study and daily for 14 days for the chronic study. Results: Imipramine showed significant antidepressant activity as demonstrated by a reduction in duration of immobility in both acute and chronic studies of forced swim test and tail suspension test. CS showed a dose dependent antidepressant activity. CS_100 demonstrated an antide-

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Differentiating antidepressants of the future: Efficacy and safety

Cited by 159 publications

References 213 publications

Antidepressivos e alterações no peso corporal

Antidepressivos e alterações no peso corporal

Effect of Oyster Mushroom on Kidney in Stress Induced Depressed Rats

Evaluation of Costus speciosus in Experimental Models of Depression in Albino Mice

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