Differentiating between large isomers and derivation of structural information by ion mobility spectrometry / mass spectrometry techniques

Karpas, Zeev; Stimac, Robert M.; Rappoport, Zvi

doi:10.1016/0168-1176(88)80093-4

Cited by 48 publications

(18 citation statements)

References 17 publications

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“…The use of a transport property to deduce structural information in the gas phase dates back to 1925 (52, 53), when diffusion constants were used to probe the structures of simple molecules such as anthracene. In the 1970s and 1980s, several groups demonstrated that ion mobilities could be used to resolve structural isomers of gas-phase ions (54,55). But it was the work that used mobilities to examine the structures of carbon cluster ions (56) that sparked the recent interest in this approach.…”

Section: Methods For Studying Vapor-phase Peptides and Proteinsmentioning

confidence: 99%

Peptides and Proteins in the Vapor Phase

Jarrold

2000

Annu. Rev. Phys. Chem.

348

341

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This article provides a review of recent studies of the properties of unsolvated (and partially solvated) peptides and proteins. The methods used to produce vapor-phase peptide and protein ions are described along with some of the techniques used to study them, such as H/D exchange, blackbody infrared radiative dissociation, and ion mobility measurements. Studies of unsolvated peptides and proteins provide information about their intrinsic intramolecular interactions. The topics covered include the role of zwitterions and salt bridges in the vapor phase, Coulomb interactions in multiply charged ions, the unfolding and refolding of vapor-phase proteins, and the stability of unsolvated helices and sheets. Finally, dehydration and rehydration studies of proteins in the vapor phase are described. These can provide exquisitely detailed information about hydration interactions, such as the enthalpy and entropy changes associated with adsorbing individual water molecules.

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Section: Methods For Studying Vapor-phase Peptides and Proteinsmentioning

confidence: 99%

Peptides and Proteins in the Vapor Phase

Jarrold

2000

Annu. Rev. Phys. Chem.

348

341

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“…Investigation of gas-phase processes of these systems, which are free of perturbation from solvents, may yield information on the structure of the protonated bases. It has been shown that ion mobility spectrometry (IMS) can provide a tool for structural investigations of gas-phase ions [1][2][3][4]. a-c0 Diamines [2] and aminoalcohols [4] were shown to undergo protoninduced cyclization under the conditions of IMS.…”

Section: Introductionmentioning

confidence: 99%

The structure of protonated diamines and polyamines

et al. 1994

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The reduced mobilities in air, at 200~ of six isomeric C7H~sN2 protonated diamines, two triamines (caldine and spermidine), and two tetramines (thermine and spermine) were measured by ion mobility spectrometric (IMS) techniques. The results indicated that all these polyamines undergo proton-induced cyclization, with the proton forming a bridge between two amino groups. It appears as if the favored configuration of the protonated polyamines involves a six-or sevenmembered ring rather than a bridge between the terminal amino groups. It is believed that in the tetramines the cyclic structure is formed between the two central, more basic, secondary amine sites.

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“…tion of this type would be fast, and indeed previous studies of keto-enol pairs have shown it to be slow [20). Other relevant studies, again using keto-enol tautamers, have shown that ion mobility spectrometry can be used to separate the tautomers [32], In this case, we suggest that this ion represents the 1088 of CO from the ion at m /z 235 (see Scheme Ill), To support this scheme, we deuterated the hydroxy group. The CID spectrum of the deuterated ion at m /z 328 (see Figure 4b) also showed ions at m rz 235 and 207, indicating that the proton from the hydroxy group is not a part of the fragment ions, supporting the structures given in Scheme III.…”

Section: Sample Preparationmentioning

confidence: 95%

Effect of tautomerization on the fast-atom bombardment tandem mass spectra of azo dyes

Borgerding

Hites

1994

J. Am. Soc. Mass Spectrom.

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The effect of tautomerization on the collision-induced dissociation of negative ions produced from sulfonated azo dyes by fast-atom bombardment (FAB) was studied by analyzing the product ion spectra of several related compounds. The mechanisms by which azo dyes fragment were found to depend on the formation and stability of tautomers. The extent of tautomerization was affected by the number and location of hydroxy groups on the dye, as well as by the FAB matrix. Ions that retained a sodium were often inhibited from forming tautomers and gave different product ions. Substitution of deuterium for hydrogen on the hydroxy groups aided in the identification of ions having more than one possible structure and provided verification of proposed mechanisms. Mechanisms involving ions retaining a sodium were verified by substituting potassium for the sodium.

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Differentiating between large isomers and derivation of structural information by ion mobility spectrometry / mass spectrometry techniques

Cited by 48 publications

References 17 publications

Peptides and Proteins in the Vapor Phase

Peptides and Proteins in the Vapor Phase

The structure of protonated diamines and polyamines

Effect of tautomerization on the fast-atom bombardment tandem mass spectra of azo dyes

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