Difficulties in Translating Appetite Sensations Effect of Turmeric-Based Beverage When Given Prior to Isoenergetic Medium- or High-Fat Meals in Healthy Subjects

Abstract

The established effect of turmeric and its curcuminoids on appetite sensations was previously shown to be mediated by gut hormones release. In in vitro and preclinical studies, curcumin was shown to induce GLP-1 secretion and improve postprandial glycemia. In humans, consumption of 220 mL turmeric-based beverage (TUR, containing 185 mg gallic acid equivalents (GAE)) prior to white wheat bread (WWB, 50 g available carbohydrate) reduced early postprandial glucose levels and induced peptide tyrosine–tyrosine (PYY) release, as well as lowered ‘desire to eat’ and ‘prospective consumption’ in a postprandial setting, compared to control. In the present study, 12 healthy participants (5 men, 7 women) were admitted. An identical beverage was given and consumed prior to isoenergetic (423 kcal) medium-fat (MF) or high-fat (HF) meals. Appetite sensations including perceived ‘hunger’, ‘desire to eat’, ‘satiety’, ‘fullness’, ‘prospective consumption’, and ‘thirst’ were measured using visual analogue scales. MF induced 18% (p = 0.039) higher ‘satiety’ compared to HF. TUR consumption prior to either MF or HF did not modulate the perceived appetite sensations. Whether macronutrient-induced appetite sensations override the actual turmeric effects warrants further investigation.

Postprandial Responses of Serum Bile Acids in Healthy Humans after Ingestion of Turmeric before Medium/High‐Fat Breakfasts

“…PLS analysis was performed to investigate whether different BAs were associated with some of the lipid markers (TG, HDL, LDL, Apo‐A1, Apo‐B, and total cholesterol) analyzed . According to the PLS loading plot ( Figure ), CA, CDCA, UDCA, T‐UDCA, T‐CA, and T‐CDCA were negatively correlated with triglycerides, while T‐LCA tended to be positively correlated with total cholesterol, HDL, and LDL.…”

“…This was a complementary study to a previous investigation of turmeric effects on appetite . The study was registered in http://clinicaltrials.gov as NCT02479334, and the Regional Ethical Board in Lund, Sweden (2015/207) approved the study.…”

Nutritional and Microbiological Characteristics of Snakehead Fish Flour (Channa Striata) and Its Modification as Weight Enhancing Supplements for Children with Tuberculosis

“…Likewise, turmeric extract contains polyphenol curcumin that has a role as an antioxidant and anti-inflammatory. It also has health benefits for increasing immunity and appetite sensations [44][45] [46].…”

Colorimetric Measurement and Functional Analysis of Selective Natural Colorants Applicable for Food and Textile Products

“…The turmeric powder improved the oxidative stability and microbiological quality of soft cheese [23]. Turmeric extract rich in curcumin reduced the aging of fresh lamb sausages during modified atmospheric packaging by causing less generation of related volatile compounds due to its antioxidant capacity [24]. The addition of turmeric to the dough of biscuits and breads greatly improved the antioxidant potential and organoleptic properties of breads and biscuits [25].…”