2006
DOI: 10.1016/j.bbmt.2005.11.411
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Diffuse alveolar hemorrhage (DAH) and infection associated alveolar hemorrhage (IAH) following hematopoietic stem-cell transplantation: Related and high risk clinical syndromes with poor response to high-dose corticosteroids

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Cited by 2 publications
(7 citation statements)
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“…[1][2][3][4]12 Notwithstanding the limitation of small sample size, we observed no benefit with high-dose corticosteroids in hemorrhage occurring after RIC allogeneic HCT. Although all patients with DAH and the majority of patients with IAH in our RIC cohort received high-dose methylprednisolone, 60-day survival from hemorrhage onset was only 28%.…”
Section: Discussioncontrasting
confidence: 56%
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“…[1][2][3][4]12 Notwithstanding the limitation of small sample size, we observed no benefit with high-dose corticosteroids in hemorrhage occurring after RIC allogeneic HCT. Although all patients with DAH and the majority of patients with IAH in our RIC cohort received high-dose methylprednisolone, 60-day survival from hemorrhage onset was only 28%.…”
Section: Discussioncontrasting
confidence: 56%
“…Although the precise mechanism of post transplant alveolar hemorrhage is not known, it is postulated to be multifactorial in origin with endothelial and alveolar damage due to chemotherapy, radiation therapy, graft-versus-host-disease (GVHD), circulating inflammatory mediators, underlying infections, and altered cardio-pulmonary hemodynamics contributing to its pathogenesis. 2,4 Decreasing the intensity of the preparative regimen using RIC may not be protective against the development of this syndrome as the other etiologic factors remain. Also, older age and a higher prevalence of comorbidities might account for the higher than expected incidence of this syndrome in patients undergoing RIC HCT.…”
Section: Discussionmentioning
confidence: 99%
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“…There are no standard therapies for DAH ( 6 ). Historically, treatment included high-dose corticosteroids ( 3 , 7 , 8 ), though recent reports suggest this approach is associated with poorer survival after HCT ( 9 11 ).…”
Section: Introductionmentioning
confidence: 99%