Diffuse alveolar hemorrhage secondary to sarcoidosis

Diaz-Menindez, Maximiliano; Sullivan, Megan M; Butendieck, Ronald R.; Abril, Andy; Majithia, Vikas; Wang, Benjamin; Berianu, Florentina

doi:10.1007/s10067-023-06556-1

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…Blood glucose and lipids have already been found to be associated with kinds of idiopathic inflammatory diseases such as rheumatoid arthritis [ 8 ] and inflammatory bowel disease [ 9 , 10 ], but their roles in the onset of sarcoidosis are not yet clear. The metabolic disorders related to sarcoidosis found so far include obesity [ 2 , 11 ], diabetes [ 12 ] and dyslipidemia [ 13 ], which conforms to our clinical experience that sarcoidosis patients tend to have more problems with blood glucose and lipids. The changes of glucose [ 14 , 15 ] and lipid [ 16 ] metabolites can also be observed in sarcoidosis patients’ blood.…”

Section: Introductionsupporting

confidence: 73%

Blood glucose and lipids are associated with sarcoidosis: findings from observational and mendelian randomization studies

Zhan,

Zhang,

Yang

et al. 2024

Respir Res

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Background Several researches have demonstrated that patients with sarcoidosis accompanied with the abnormality in blood glucose and/or lipids, however, the causal relationship between them remains uncertain. To elucidate the potential association and causality of blood glucose and lipids with sarcoidosis, we conducted a propensity score matching (PSM)-based observational study combined with mendelian randomization (MR) analysis. Methods All subjects in this study were retrospectively collected from Tongji Hospital during 2010 and 2023. 1:1 PSM was employed to control the potential confounders as appropriate. Univariable and multivariable logistic regression analyses were performed to estimate the associations of sarcoidosis with fasting glucose, high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC), total cholesterol (TC), and total triglyceride (TG). The further subtype analysis was also conducted. Afterwards, a bidirectional MR analysis based on public data deeply explored the causality among the 5 candidate traits and sarcoidosis, for which the inverse-variance weighted (IVW) method was utilized as the main inferring approach. Results In the observational study, a total number of 756 subjects were enrolled, with 162 sarcoidosis patients and 594 non-sarcoidosis participants, while 160 pairs of subjects were matched after PSM. Multivariable logistic regression analysis indicated that HDLC (OR: 0.151; 95% CI: 0.056–0.408; P < 0.001) and TC (OR: 3.942; 95% CI: 2.644–5.877; P < 0.001) were strongly associated with sarcoidosis. Subtype analysis showed that low HDLC was independently correlated to risk of lesions in bronchus and lungs, and mediastinal lymph nodes, while high TC was to cervical lymph nodes. In MR analysis, high fasting glucose, low HDLC, and high TC were identified as the causal factors of sarcoidosis. Conclusion HDLC and TC had the potential to influence the risk of sarcoidosis, which could be regarded as predictors and may provide new diagnostic and therapeutic targets for sarcoidosis.

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Section: Introductionsupporting

confidence: 73%

Blood glucose and lipids are associated with sarcoidosis: findings from observational and mendelian randomization studies

Zhan,

Zhang,

Yang

et al. 2024

Respir Res

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“…It can be immune-mediated or nonimmune-mediated. Immune causes are 30-40% of all cases [7,8]. Many systemic diseases can cause DAH, but the pathogenesis is unclear.…”

Section: Introductionmentioning

confidence: 99%

Diffuse alveolar haemorrhage – case report and literature review

Jerzak,

Bindas,

Szczukocka

2024

J Pre Clin Clin Res.

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Diffuse alveolar haemorrhage (DAH) is a pulmonary disease where bleeding into alveoli via damaged basement membrane causes respiratory failure. Clinical manifestations are: anaemia, haemoptysis, dyspnea, fever and hypoxic respiratory failure. The origin can be immune-mediated or non-immune-mediated. Auto-immune causes of DAH are considered more serious prognostically. Vasculitis is the most common cause. To decrease mortality DAH needs to be recognized early and requires prompt treatment. Despite major mortality, treatment options are only empirical. One of them is treatment with steroids combined with rituximab/cyclophosphamide. In the most severe cases, plasma exchange therapy, mechanical ventilation or veno-venous extracorporal membrane oxygenation (vv-ECMO) are used. Diffuse alveolar bleeding should be differentiated from coagulophaty, cryptogenic organizing pneumonia (COP), acute interstitial pneumonia (AIP), allergic alveolitis, and acute respiratory distress syndrome (ARDS).

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Diffuse alveolar hemorrhage secondary to sarcoidosis

Cited by 2 publications

References 7 publications

Blood glucose and lipids are associated with sarcoidosis: findings from observational and mendelian randomization studies

Blood glucose and lipids are associated with sarcoidosis: findings from observational and mendelian randomization studies

Diffuse alveolar haemorrhage – case report and literature review

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