Diffuse B Cell Non-Hodgkin’s Lymphoma Presenting Atypically as Periprosthetic Joint Infection in a Total Hip Replacement

Abstract

The occurrence of extranodal primary B cell non-Hodgkin's lymphoma is rare. Total hip replacement is one of the most common orthopaedic procedures performed. There has been an increased incidence of primary lymphomas involving periprosthetic sites. Chronic inflammation due to metal debris arising from the prosthetic implants has been evidenced as one of the causes for the development of soft tissue lymphomas albeit rarely. We describe a case report of a 77-year-old patient who had underwent a cemented total hip replacement in the past who further developed large B cell primary non-Hodgkin's lymphoma. She presented initially with signs and symptoms highly suggestive of underlying periprosthetic infection. The radiological imaging was also indicative of periprosthetic infection. The diagnosis was eventually confirmed after an open biopsy. This case underlines the importance of considering and including soft tissue malignancy in the differential diagnosis of suspected chronic periprosthetic infection.

EBV+ diffuse large B-cell lymphoma associated with chronic inflammation expands the spectrum of breast implant-related lymphomas

“…1 They have been more recently described in bones, joints, or periarticular soft tissues in association with metallic implants. 10,11 Our series suggests that breast implants could be added to the list of foreign bodies that could favor the onset of DLBCL occurring in the context of chronic inflammation.…”

Diffuse Large B-Cell Lymphoma Associated with a Chronic Inflammatory Condition Induced by Metallic Implants: A Case Report

“…Metallic implant-associated lymphoma is extremely rare ( 8 ). To our knowledge, only 14 cases of DLBCL associated with metallic implants, including our patient’s case, have been reported up to 2020 ( 1 3 9 ). In these cases, the age at lymphoma diagnosis ranged from 25 to 85 years, and no sex bias was noted ( 1 3 9 ).…”

Seroma en pierna por implantes de pantorrilla

“…Los esfuerzos físicos pueden desprender el implante causando microtraumatismos y formación de seroma. 1,3,5,[34][35][36][37][38][39] El caso que presentamos tenía 28 años con sus implantes. El desgaste por la acción enzimática de los leucocitos debió ser muy importante.…”