Diffuse cutaneous mastocytosis in a newborn calf

Palyada, Kiran S.; Scott, Danny W.; Schlafer, Donald H.; Czajkowski, Melissa

doi:10.1111/j.1365-3164.2008.00666.x

Cited by 9 publications

(10 citation statements)

References 7 publications

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“…2 UP has rarely been reported in veterinary medicine, with scattered reports in dogs, cats, horses and cattle. [3][4][5][6][7][8] Reports in cats have been isolated to four breeds: Sphynx, Devon Rex, Himalayan and Siamese. 7 Clinical differential diagnoses for cases of UP include allergic dermatitis, Notoedres cati, Demodex gatoi, dermatophytosis and cutaneous mastocytosis.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7][8] Reports in cats have been isolated to four breeds: Sphynx, Devon Rex, Himalayan and Siamese. 7 Clinical differential diagnoses for cases of UP include allergic dermatitis, Notoedres cati, Demodex gatoi, dermatophytosis and cutaneous mastocytosis. More diffuse distribution of monomorphic cells rather than solely perivascular aggregates of mast cells or pleiomorphic mast cells on histopathology lends support for a diagnosis of UP over allergic dermatitis or cutaneous mastocytosis, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Urticaria pigmentosa-like skin disease in a domestic shorthair cat

Tomich

Pieper

2019

Journal of Feline Medicine and Surgery Open Reports

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Case summaryA 14-month-old castrated male domestic shorthair cat presented with an 8 month history of severe pruritus, alopecia, papules and excoriations. Initial evaluation and treatment prior to referral included skin scrape, cytology, two strict food trials, dermatophyte culture, and bacterial culture and sensitivity, as well as antibiotic therapy, empiric treatment for mites, steroids and ciclosporin A (Atopica; Elanco). The cat was referred to the Dermatology and Otology Clinic at the University of Illinois Veterinary Teaching Hospital for further diagnostics and treatment. Skin scrapes were unremarkable. Cytology showed rare bacteria and moderate neutrophils. The cat was given an injection of triamcinolone acetonide, which was ineffective. Oclacitinib (Apoquel; Zoetis) was given for 4 weeks with no improvement. A skin biopsy was performed, and histopathology showed large numbers of well-differentiated monomorphic mast cells with fewer eosinophils that diffusely infiltrated the superficial dermis, supportive of urticaria pigmentosa. Oral dexamethasone and cetirizine hydrochloride were initiated, and the cat responded favorably. At the time of writing, the cat continues to do well on cetirizine hydrochloride with only intermittent tapering courses of dexamethasone.Relevance and novel informationTo the best of our knowledge, this is the first reported case of urticaria pigmentosa in a domestic shorthair cat. This case also highlights the importance of biopsy after a thorough, systematic work-up in a cat with severe, intractable pruritus to reveal an uncommon disease pattern, as well as the efficacy of oral dexamethasone and cetirizine hydrochloride as a potential management option.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Urticaria pigmentosa-like skin disease in a domestic shorthair cat

Tomich

Pieper

2019

Journal of Feline Medicine and Surgery Open Reports

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“…Clinical evaluation included haematology, fine needle aspiration from the nodules and radiographs. The only abnormality on a serum chemistry panel and complete blood count was a moderate leucocytosis (16.5 × 10/L; reference range 5–12 × 10/L) with a left shift. Radiography of the thorax was unremarkable and there were no features of mast cell mediator related disease such as pruritus, oedema, other circulatory disturbances, respiratory distress or abdominal pain.…”

Section: Case Reportmentioning

confidence: 98%

“…The major forms of CM described in humans include cutaneous mastocytoma, multifocal mastocytosis (also known as urticaria pigmentosa, UP) and diffuse CM . CM arising early in life sporadically occurs in dogs, cats and cattle, and can arise in a multifocal or diffuse pattern . In addition, a maculopapular form of CM is a rare disorder in young horses; only two case reports of CM in foals have been published .…”

Section: Introductionmentioning

confidence: 99%

Cutaneous form of maculopapular mastocytosis in a foal

Junginger

Geburek

Khan

et al. 2016

Veterinary Dermatology

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The case presented here fulfils the criteria of equine cutaneous maculopapular mastocytosis (ECMM), representing a rare entity in foals that is reported to be associated with spontaneous regression, although the long-term prognosis is not known. Unlike in previous reports, lesions described here were restricted to the skin. This may imply that ECMM is primarily a dermal disease sharing similarities with urticaria pigmentosa in young children.

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“…1,2,5,8,10 In domestic animals, most reported cases of mastocytosis were sporadic or isolated, published descriptions being centered on the skin, bone marrow, liver, spleen, kidney, intestine, or lymph node of dogs, pigs, horses, or cattle. 2,3,10,14,16 Even if mastocytosis may affect different organs, selective vascular system involvement is uncommon. There are few relevant descriptions in domestic animals, with only 1 report of a variant of systemic mastocytosis in a cow that involved almost all arterioles in the skeletal muscles.…”

mentioning

confidence: 99%

Hepatic Mastocytosis in Japanese Black Cattle

Ohfuji¹

2017

Vet Pathol

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In 5 Japanese Black steers (2-2.4 years old) that originated from 5 different feedlots, the livers were found at slaughter to have multiple nodular or cordlike lesions (5 steers) and an extensive fibrotic area (1 steer). Microscopic changes included extensive fibroplasia in the portal tracts and chronic proliferative endophlebitis-like lesions confined to the portal vein branches. Fibroplasia was much more prominent in the macroscopic fibrotic lesion of 1 steer. Portal vein branches presented irregular variciform dilation of the vascular lumen and fibroplastic changes in the subendothelial areas that showed occasional hemorrhage and were simultaneously infiltrated with large numbers of mast cells and moderate to large numbers of eosinophils. Within these subendothelial regions, not only did mast cells exhibit cytologically atypical features, but they also formed multifocal nodules. The venous lesions may represent a variant of mastocytosis with specific involvement of the hepatic portal vein branches in cattle.

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Diffuse cutaneous mastocytosis in a newborn calf

Cited by 9 publications

References 7 publications

Urticaria pigmentosa-like skin disease in a domestic shorthair cat

Urticaria pigmentosa-like skin disease in a domestic shorthair cat

Cutaneous form of maculopapular mastocytosis in a foal

Hepatic Mastocytosis in Japanese Black Cattle

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