Diffuse dermal angiomatosis: a variant of reactive cutaneous angioendotheliomatosis

Krell, James; Sánchez, Ramón L.; Solomon, Alvin R.

doi:10.1111/j.1600-0560.1994.tb00713.x

Cited by 108 publications

(88 citation statements)

References 8 publications

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“…Although DDA was described initially in 1994 as a variant of reactive cutaneous angioendotheliomatosis, 1 it was recently recognized as a distinct clinical pathologic entity in the spectrum of cutaneous reactive angiomatoses. 8 All the reported cases of DDA have involved women (age range, 28-63 years), with most of them in their 50s (Table).…”

Section: Commentmentioning

confidence: 99%

“…The most efficient method for accomplishing this improvement is revascularization of the affected area. 1,6 Corticosteroid therapy was used in 1 patient, and the lesion completely resolved after 2 months. 2 Our patient had noted improvement with isotretinoin therapy, which was reported to be effective in 1 patient, possibly because of its antiangiogenesis effect.…”

Section: Commentmentioning

confidence: 99%

“…Since its first description by Krell et al 1 in 1994, a total of 8 cases of DDA have been reported in the Englishlanguage literature (Table). [1][2][3][4][5][6][7] Involvement of the breast is rare, having been reported in only 2 patients. 4,5 Neither of these patients had a relevant medical history or a vaso-occlusive disorder, but both had large pendulous breasts.…”

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confidence: 99%

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Diffuse Dermal Angiomatosis of the Breast

2006

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Background: Diffuse dermal angiomatosis is rare and usually considered a variant of reactive angioendotheliomatosis. It generally involves the extremities of patients with severe vascular disease and other comorbidities. Two patients with breast involvement have been described; however, neither had a relevant medical history or a vaso-occlusive disorder, but both had large pendulous breasts, and 1 was positive for IgM anticardiolipin and antinuclear antibodies.Observations: A 53-year-old woman had a reticulated, erythematous plaque with superficial ulceration and underlying tender nodules on her left breast. She had a history of cardiovascular disease and was a heavy smoker. Biopsy of the lesion showed diffuse proliferation of additional endothelial cells and small bland vessels within the pap-illary and upper reticular dermis. Angiography showed almost complete occlusion of the subclavian artery proximally. Diffuse dermal angiomatosis was diagnosed. With isotretinoin therapy, the lesions improved. One month later, after percutaneous subclavian arterial revascularization, the lesion resolved completely. A literature review suggested that a history of heavy smoking, in addition to a history of vascular disease, may be important in the pathogenesis of diffuse dermal angiomatosis.Conclusions: Clinical acumen is crucial to diagnose diffuse angiomatosis of the breast. Appropriate treatment to alleviate hypoxia may improve the patient's condition.

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Section: Commentmentioning

confidence: 99%

Section: Commentmentioning

confidence: 99%

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Diffuse Dermal Angiomatosis of the Breast

2006

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“…RAE, on the other hand, has remained pathogenetically less well elucidated, although hypotheses have been proposed regarding RAE as a hypersensitivity reaction to foreign antigens suggested by its frequent association with infections [1, 2, 5, 12, 13, 14]. Moreover, an association with milk intolerance [13], luminal cryoprotein deposition [15], cold agglutinins [16], antiphospholipid syndrome [17]and severe atherosclerotic disease [18]has been described.…”

Section: Introductionmentioning

confidence: 99%

Increased Expression of VEGF in Glomeruloid Reactive Angioendotheliomatosis

Eming¹,

Sacher²,

Eich³

et al. 2003

Dermatology

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Reactive angioendotheliomatosis (RAE) is a very rare disorder characterized by marked proliferation of endothelial cells. It is often associated with infections, such as subacute bacterial endocarditis, but has also been described as an early sign of a developing hematological malignancy. We report the case of a 71-year-old Caucasian female who developed lupus-like RAE lesions. A thorough diagnostic workup and subsequent 3-year clinical follow-up revealed no sign of an underlying infectious or neoplastic disorder. Repetitive serum immunofixations were only once consistent with a monoclonal gammopathy of undetermined significance. In lesional skin, the pronounced bud-like endothelial cell formation was associated with an increased epidermal expression of vascular endothelial growth factor (VEGF), a potent angiogenic mediator. In accordance with the paracrine action of epidermally derived VEGF, vascular endothelial cells in lesional skin revealed increased expression of the VEGF receptor VEGFR-2 (KDR). This case suggests a possible role of epidermally derived VEGF in endothelial cell proliferation in RAE.

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“…Innerhalb [1,2]. Die Hautverände-rungen sind bei Vorliegen stenosierender Gefäßprozesse überwiegend an den distalen Extremitäten lokalisiert [2].…”

Section: Histologieunclassified