Diffuse dermal angiomatosis mimicking inflammatory breast carcinoma

Abstract

Diffuse dermal angiomatosis (DDA) is a rare pathologically distinct subtype of reactive angioendotheliomatosis. In the literature, few biopsy-proven cases involving breast skin have been reported. We present a case of a 49-year-old female who presented with an indurated, erythematous, weeping, puckered and tender lesion with focal ulceration. Mammography demonstrated diffuse cutaneous and trabecular thickening concerning for inflammatory breast carcinoma. A punch biopsy demonstrated findings consistent with DDA. To our knowledge, this is the first reported case of DDA mimicking inflammatory carcinoma of the breast by clinical and radiologic examination.

Diffuse Dermal Angiomatosis of Bilateral Breasts, A Distinct Entity of Reactive Angiomatoses: A Clinicopathologic Challenge

“…It is important to note that DDA does not show significant atypia or increased mitotic figures activity. This absence of cytologic atypia helps to differentiate DDA from more aggressive vascular neoplasms, such as cutaneous angiosarcoma, inflammatory breast carcinoma, 6 atypical vascular proliferation, and Kaposi sarcoma. Immunohistochemical staining plays a pivotal role in supporting the diagnosis of DDA.…”

Get It Off Your Chest: A Narrative Review of Breast Ulcers

“…The treatment is surgical correction. Recurrence is uncommon 26,27 . Although DDA is benign, it may be alarming clinically and may end with cutaneous ulceration 27 …”

“…26,27 Although DDA is benign, it may be alarming clinically and may end with cutaneous ulceration. 27 Mondor Disease. Mondor disease is superficial thrombophlebitis of the breast, an uncommon and self-limiting disease that only rarely causes ulceration.…”

Cutaneous Disorders of the Breast

“…Breast reduction surgery appears to be a viable treatment option in women with macromastia and might provide definitive healing (Galambos et al 2017). • Differential diagnosis: Inflammatory breast carcinoma (Hui et al 2018), cellulitis, panniculitis, pressure ulcers, and vasculitis.…”