Diffuse hepatic and splenic Tc-99m MDP tracer uptake in case of multiple myeloma

Sood, Ashwani; Seam, Rajeev Kumar; Sethi, Sandeep; Gupta, Manish

doi:10.4103/0972-3919.72692

Cited by 6 publications

(7 citation statements)

References 9 publications

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“…Diffuse and intense hepatic uptake of bone imaging agent can also be due to a variety of causes including, diffuse hepatic necrosis, repeated iron injections, administration of contrast media after bone scan agent injection, idiopathic hepatic uptake, acute hypoxic hepatitis or hypoxia secondary to respiratory failure, amyloidosis associated with plasma cell dyscrasia and also in late stage of multiple myeloma. [ 10 12 ]…”

Section: Discussionmentioning

confidence: 99%

Hepatic metastasis arising from diverse primary pathologies diagnosed on 99mTc-Methylene diphosphonate bone scan

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Hepatic metastasis arising from diverse primary pathologies diagnosed on 99mTc-Methylene diphosphonate bone scan

et al. 2015

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“…On the other hand, nonosseous uptake of bone-seeking radiopharmaceuticals is observed in different conditions and organs which are necessary to distinguish the pathophysiological causes [ 5 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

Diffuse Hepatic and Spleen Uptake of Tc-99m MDP on Bone Scintigraphy Resembling Liver-Spleen Scintigraphy in a Patient of Plasma Cell Tumor

Ravanbod

Nemati

Javadi

et al. 2014

Case Reports in Radiology

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The present case demonstrates a diffuse intense hepatic and, to a lesser degree, spleen, Tc-99m MDP uptake on a routine bone scintigraphy resembling liver-spleen imaging. A 49-year-old female with a history of anaplastic plasma cell tumor and suffering from bone pain was referred for bone scintigraphy to evaluate possible bone metastases. The bone scintigraphy showed diffuse hepatic and spleen uptake of Tc-99m MDP resembling liver-spleen imaging. Furthermore, bone uptake of Tc-99m MDP was significantly diminished and there were no abnormal foci throughout the skeleton. The bone scintigraphy of the present case of an anaplastic plasma cell tumor suggests the possible presence of amyloidosis.

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“…[ 11 ] In another study, Sood et al reported that Tc-99m-hydroxy-methane-diphosphonate bone scan results in diffuse and high hepatic uptake, hypoxia from respiratory failure, and the development of hepatic necrosis in MM patients. [ 12 ] Adenosine monophosphate-activated protein kinase activator metformin has been demonstrated to have synergistic effects with dexamethasone against MM and to decrease myeloma proliferation through the IGF-1R/PI3K/AKT/mTOR pathway. [ 13 ] Although there are no direct studies linking methane-containing compounds to MM, there may be an association in the context of ligand and cell adhesion-mediated drug resistance.…”

Section: Introductionmentioning

confidence: 99%

Effects of methane emissions on multiple myeloma-related mortality rates: A World Health Organization perspective

Özlü,

Yalçin

2024

Medicine

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In this research, it was aimed to evaluate effects of methane emissions on multiple myeloma related mortality rates. Two countries in Europe (Germany and Netherlands) and 1 country for each region (Turkey, USA, Brazil, Egypt, and Australia) were selected within The World Health Organization Database. Multiple myeloma mortality rates of countries between 2009 and 2019 were used as dependent variable of the research. Methane emission level and agriculture methane levels of countries were used as independent variables from The World Bank Database. Current health expenditure and healthy life expectancy were used as controlling variables. Multiple myeloma-related mortality rate was the highest in the USA, followed by Germany, Brazil, Turkey, Australia, Netherlands, and Egypt. Difference analysis results were significant (P < .05). Methane and agriculture methane emissions were the highest in the USA. Multiple myeloma mortality was positively correlated with methane emissions (R = 0.504; P < .01), agricultural methane emissions (R = 0.705; P < .01), and current health expenditure (R = 0.528; P < .01). According to year and country controlled correlation analysis results, multiple myeloma mortality (MMM) was positively correlated with methane emissions (R = 0.889; P < .01), agricultural methane emissions (R = 0.495; P < .01), and current health expenditure (R = 0.704; P < .01). Methane emission (B = 0.01; P < .05), Germany (B = 9010.81; P < .01), the USA (B = 26516.77; P < .01), and Brazil (B = 4886.14; P < .01) had significant effect on MMM. Nonagricultural methane production has an increasing effect on MMM. Therefore, by looking at the differences between agricultural methane emissions and general methane emissions, studies can be conducted that allow for more effective global comparisons.

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Diffuse hepatic and splenic Tc-99m MDP tracer uptake in case of multiple myeloma

Cited by 6 publications

References 9 publications

Hepatic metastasis arising from diverse primary pathologies diagnosed on 99mTc-Methylene diphosphonate bone scan

Hepatic metastasis arising from diverse primary pathologies diagnosed on 99mTc-Methylene diphosphonate bone scan

Diffuse Hepatic and Spleen Uptake of Tc-99m MDP on Bone Scintigraphy Resembling Liver-Spleen Scintigraphy in a Patient of Plasma Cell Tumor

Effects of methane emissions on multiple myeloma-related mortality rates: A World Health Organization perspective

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