Diffuse large B‐cell lymphoma with spindle cell features

Nozawa, Yoshihiro; Wang, J; Weiss, Lawrence M.; Kikuchi, Satoshi; Hakozaki, Handou; M, Abe

doi:10.1046/j.1365-2559.2001.01072.x

Cited by 21 publications

(22 citation statements)

References 3 publications

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“…These features, including spindled morphology, have been described in large B-cell lymphoma. 19,20 Therefore, the diagnosis of H/DS is based largely upon the immunophenotypic profile of neoplastic cells, per the 2008 World Health Organization classification. 17 The characteristic antigens expressed in HS include CD163, CD68 ( Figure 1, B, inset), and lysozyme.…”

Section: Histologic and Immunophenotypic Findingsmentioning

confidence: 99%

Histiocytic/Dendritic Cell Transformation of B-Cell Neoplasms: Pathologic Evidence of Lineage Conversion in Differentiated Hematolymphoid Malignancies

Stoecker

Wang

2013

Archives of Pathology &Amp; Laboratory Medicine

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B-cell lymphomas, such as low-grade follicular lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma, can transform to histiocytic/dendritic cell sarcoma (H/DS) in rare cases. The diagnosis of this unconventional neoplastic evolution relies on a combination of immunophenotypic analysis and genotypic studies. A genotype identical to that of the primary B-cell neoplasm in a secondary neoplasm with H/DS immunophenotype supports the lineage conversion to H/DS. Putative mechanisms for this unusual phenomenon include dedifferentiation, common immature progenitor, and transdifferentiation models, the latter of which is suggested by clinical laboratory data at the present time. Elucidation of the molecular mechanisms governing this lineage conversion may facilitate the understanding of carcinogenesis of not only hematopoietic but also nonhematolymphoid neoplasms. The clinical outcome of secondary H/DS is dismal, as observed in sporadic cases, and the optimal treatment remains to be determined.

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Section: Histologic and Immunophenotypic Findingsmentioning

confidence: 99%

Histiocytic/Dendritic Cell Transformation of B-Cell Neoplasms: Pathologic Evidence of Lineage Conversion in Differentiated Hematolymphoid Malignancies

Stoecker

Wang

2013

Archives of Pathology &Amp; Laboratory Medicine

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“…The spectrum of DLBCL is extremely broad and includes many variants [19]. Among these morphological variants, DLBCL with spindle cell features is extremely rare [4,19], and there have been no reports of this variant of DLBCL arising in the liver to date.…”

Section: Discussionmentioning

confidence: 99%

“…Among these morphological variants, DLBCL with spindle cell features is extremely rare [4,19], and there have been no reports of this variant of DLBCL arising in the liver to date. Table 1 shows a summary of the available data for 13 cases, including the present case [3, 9-11, 19, 23].…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that lymphoma cells may assume a spindle configuration when they infiltrate bone and soft tissues [4,13,19]. Lymphoma cells are also occasionally spindle-shaped in the absence of a stromal influence.…”

Section: Discussionmentioning

confidence: 99%

“…Lymphoma cells are also occasionally spindle-shaped in the absence of a stromal influence. It is currently believed that the spindle formation probably results from aberrations in the cytoskeleton, and Nozawa et al [19] reported that SMA expression may be associated with the spindle morphology of lymphoma cells. On the other hand, lymphoma with spindle cell features has been reported to be associated with an exuberant mesenchymal reaction [13,14], which predominantly occurs in the peripheral portion of the tumor, and the spindle cells lack nuclear atypia [4].…”

Section: Discussionmentioning

confidence: 99%

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Primary hepatic lymphoma with spindle cell components: a case report

et al. 2006

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Diffuse large B-cell lymphoma (DLBCL) with spindle cell components is extremely rare and often misdiagnosed as carcinoma or sarcoma. Here, we present a case of primary DLBCL with spindle cell components arising in the liver, for which a preoperative diagnosis by needle biopsies was unsuccessful. The patient was a 70-year-old man with a continuous cough. Thoracic computed tomography incidentally detected a mass of 5 cm in diameter in his liver. The initial and second needle biopsies from the liver mass were pathologically diagnosed as suspicious for sarcomatoid hepatocellular carcinoma. He underwent an extended left hepatectomy. Histological examination revealed a diffuse or epithelioid arrangement of round and polygonal cells, mixed with the fascicles of spindle-shaped cells. Immunohistochemically, all the morphological types of tumor cells showed positive reactions for a lymphocytic marker (CD45RB) and B-cell markers (CD20 and CD79a). Double-immunostaining revealed that the spindle-shaped tumor cells expressed CD20, but never expressed alpha-smooth muscle actin. Malignant lymphoma with a spindle cell morphology is quite uncommon, and this variant can be a diagnostic pitfall, especially in tiny biopsy specimens. We emphasize that pathologists should be reminded of lymphoma as a differential diagnosis of spindle cell tumors.

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Hematopoietic Disorders

2018

Atlas of Dermatopathology

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Diffuse large B‐cell lymphoma with spindle cell features

Cited by 21 publications

References 3 publications

Histiocytic/Dendritic Cell Transformation of B-Cell Neoplasms: Pathologic Evidence of Lineage Conversion in Differentiated Hematolymphoid Malignancies

Histiocytic/Dendritic Cell Transformation of B-Cell Neoplasms: Pathologic Evidence of Lineage Conversion in Differentiated Hematolymphoid Malignancies

Primary hepatic lymphoma with spindle cell components: a case report

Hematopoietic Disorders

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