Diffuse optical spectroscopy of breast tissue extended to 1100 nm

Taroni, Paola; Bassi, Andrea; Comelli, Daniela; Farina, Andrea; Cubeddu, Rinaldo; Pifferi, Antonio

doi:10.1117/1.3251051

Cited by 73 publications

(80 citation statements)

References 23 publications

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“…In order to reduce dimensionality of the inverse problem, absorption and reduced scattering were restricted to exhibit predefined spectral shapes. Absorption was parameterized by eight principle component spectra obtained from literature [17,40,41]. NIR absorption changes were assumed to be predominantly influenced by the following compounds: oxy-(HbO 2 ) and deooxy-hemoglobin (Hb), oxy-(MbO 2 ) and deoxy-myoglobin (Mb), metmyoglobin (Mmb), lipid, water (H 2 O), and collagen.…”

Section: Nirs Data Acquisition and Processingmentioning

confidence: 99%

Near-infrared spectroscopy integrated catheter for characterization of myocardial tissues: preliminary demonstrations to radiofrequency ablation therapy for atrial fibrillation

Singh‐Moon¹,

Marboe²,

Hendon³

2015

Biomed. Opt. Express

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Effects of radiofrequency ablation (RFA) treatment of atrial fibrillation can be limited by the ability to characterize the tissue in contact. Parameters obtained by conventional catheters, such as impedance and temperature can be insufficient in providing physiological information pertaining to effective treatment. In this report, we present a near-infrared spectroscopy (NIRS)-integrated catheter capable of extracting tissue optical properties. Validation experiments were first performed in tissue phantoms with known optical properties. We then apply the technique for characterization of myocardial tissues in swine and human hearts, ex vivo. Additionally, we demonstrate the recovery of critical parameters relevant to RFA therapy including contact verification, and lesion transmurality. These findings support the application of NIRS for improved guidance in RFA therapeutic interventions.

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Section: Nirs Data Acquisition and Processingmentioning

confidence: 99%

Near-infrared spectroscopy integrated catheter for characterization of myocardial tissues: preliminary demonstrations to radiofrequency ablation therapy for atrial fibrillation

Singh‐Moon¹,

Marboe²,

Hendon³

2015

Biomed. Opt. Express

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“…The aim of the present work is to explore the aptness of CPG fibers to perform time-domain broadband diffuse optical spectroscopy (TD-DOS) deep into biological tissues. Since TD-DOS can provide absolute estimate of the absorption and reduced scattering spectra of the diffusive medium [19,20], it conveys information on the chemical composition (mainly water, oxy-and deoxy-hemoglobin, water, lipids, collagen), on the functional status (e. g. oxygenation) and on the scattering properties (changes in tissue microstructure, edema) [21]. Such information can then be related to the tissue regeneration, to the healing process or to a harmful evolution.…”

Section: Introductionmentioning

confidence: 99%

Towards the use of bioresorbable fibers in time‐domain diffuse optics

Sieno

Boetti

Mora

et al. 2017

Journal of Biophotonics

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In the last years bioresorbable materials are gaining increasing interest for building implantable optical components for medical devices. In this work we show the fabrication of bioresorbable optical fibers designed for diffuse optics applications, featuring large core diameter (up to 200 mm) and numerical aperture (0.17) to maximize the collection efficiency of diffused light. We demonstrate the suitability of bioresorbable fibers for timedomain diffuse optical spectroscopy firstly checking the intrinsic performances of the setup by acquiring the instrument response function. We then validate on phantoms the use of bioresorbable fibers by applying the MEDPHOT protocol to assess the performance of the system in measuring optical properties (namely, absorption and scattering coefficients) of homogeneous media. Further, we show an ex-vivo validation on a chicken breast by measuring the absorption and scattering spectra in the 500-1100 nm range using interstitially inserted bioresorbable fibers. This work represents a step toward a new way to look inside the body using optical fibers that can be implanted in patients. These fibers could be useful either for diagnostic (e. g. for monitoring the evolution after surgical interventions) or treatment (e. g. photodynamic therapy) purposes. Picture: Microscopy image of the 100 mm core bioresorbable fiber.

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“…To resolve this problem, we calculated the maximum probing depths of the PSI geometry at various sample optical properties using Monte Carlo simulations. In the simulations, we selected a wide spectrum of sample optical properties based on tissue optical properties previously reported by several groups in the wavelength range from 500 to 1000 nm [14,[24][25][26][27]. The probing depths of 1071 samples with different optical properties were determined using Monte Carlo simulation to generate the plot shown in Fig.…”

Section: Probing Depth Of the Planar Source Illumination Geometrymentioning

confidence: 99%

A linear gradient line source facilitates the use of diffusion models with high order approximation for efficient, accurate turbid sample optical properties recovery

Lee¹,

Hung²,

Liao³

et al. 2014

Biomed. Opt. Express

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Abstract:In this paper, we demonstrate that a scanning MEMS mirror can be employed to create a linear gradient line source that is equivalent to a planar source. This light source setup facilitates the use of diffusion models of increased orders of approximation having closed form solution, and thus enhance the efficiency and accuracy in sample optical properties recovery. In addition, compared with a regular planar light source, the linear gradient line source occupies much less source area and has an elevated measurement efficiency. We employed a δ-P 1 diffusion equation with a closed form solution and carried out a phantom study to understand the performance of this new method in determining the absorption and scattering properties of turbid samples. Moreover, our Monte Carlo simulation results indicated that this geometry had probing depths comparable to those of the conventional diffuse reflectance measurement geometry with a source-detector separation of 3 mm. We expect that this new source setup would facilitate the investigating of superficial volumes of turbid samples in the wavelength regions where tissue absorption coefficients are comparable to scattering coefficients.

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Diffuse optical spectroscopy of breast tissue extended to 1100 nm

Cited by 73 publications

References 23 publications

Near-infrared spectroscopy integrated catheter for characterization of myocardial tissues: preliminary demonstrations to radiofrequency ablation therapy for atrial fibrillation

Near-infrared spectroscopy integrated catheter for characterization of myocardial tissues: preliminary demonstrations to radiofrequency ablation therapy for atrial fibrillation

Towards the use of bioresorbable fibers in time‐domain diffuse optics

A linear gradient line source facilitates the use of diffusion models with high order approximation for efficient, accurate turbid sample optical properties recovery

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