Diffuse Papular Rash in a Young Woman: Answer

Hinojosa, Jorge A.; Maxim, Elena; Garza-Chapa, Juana Irma; Tovar‐Garza, Andrea; Susa, Joseph

doi:10.1097/dad.0000000000001144

Cited by 1 publication

(2 citation statements)

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Section: Discussionmentioning

confidence: 99%

“…We performed a literature review of cases of granulomatous secondary syphilis in which the diagnostic work-up included immunohistochemistry for the detection of spirochetes in skin biopsy specimens. Table 1 summarises the main findings observed in these cases [2,3,5,6,[15][16][17][18][19][20][21][22][23]. The literature search was performed in the PubMed database using the keywords 'granuloma' and 'syphilis' or 'granulomatous syphilis' and was limited to articles written in English and published until March 2023.…”

Section: Discussionmentioning

confidence: 99%

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Granulomatous Secondary Syphilis: A Case Report with a Brief Overview of the Diagnostic Role of Immunohistochemistry

Ambrogio,

Cazzato,

Foti

et al. 2023

Pathogens

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The diagnosis of syphilis can be challenging for dermatologists and dermatopathologists. In particular, secondary syphilis can have different clinical and histopathological presentations. A granulomatous tissue response is an unusual finding in secondary syphilis. We report the case of a 77-year-old man who presented with a 4-week history of non-pruritic generalised macules, papules, nodules and plaques. Histopathologically, there was a dense perivascular and periadnexal lympho-histiocytic dermal infiltrate with non-palisading and non-caseifying epithelioid granulomas and abundant plasma cells. The diagnosis of syphilis was confirmed by serology and immunohistochemical detection of Treponema pallidum in the biopsy specimen. A brief overview of the diagnostic role of immunohistochemistry is also provided, with particular emphasis on reported cases of granulomatous secondary syphilis.

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