Diffuse reflectance spectroscopy in Barrett’s Esophagus: developing a large field‐of‐view screening method discriminating dysplasia from metaplasia

Douplik, Alexandre; Zanati, Simon; Saiko, Gennadi; Streutker, Catherine; Loshchenov, Maxim; Adler, Desmond C.; Cho, Sarah; Chen, Dean; Cirocco, Maria; Marcon, Norman E.; Fengler, John; Wilson, Brian C.

doi:10.1002/jbio.201200114

Cited by 29 publications

(24 citation statements)

References 30 publications

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“…These optical properties establish the principles of diffuse reflectance spectroscopy . This method can be implemented for tissue diagnostics such as discrimination of dysplasia from metaplasia in Barrett's esophagus as an adjuvant to autofluorescence endoscopy . Sensitivity and specificity for a test data set of 0.67% and 0.85%, respectively, showed that this technique could be implemented in wide‐field imaging mode to improve the accuracy of existing endoscopy techniques for finding early pre‐malignant lesions.…”

Section: Tissue Diagnosticsmentioning

confidence: 99%

Modern trends in biophotonics for clinical diagnosis and therapy to solve unmet clinical needs

Krafft

2016

Journal of Biophotonics

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This contribution covers recent original research papers in the biophotonics field. The content is organized into main techniques such as multiphoton microscopy, Raman spectroscopy, infrared spectroscopy, optical coherence tomography and photoacoustic tomography, and their applications in the context of fluid, cell, tissue and skin diagnostics. Special attention is paid to vascular and blood flow diagnostics, photothermal and photodynamic therapy, tissue therapy, cell characterization, and biosensors for biomarker detection.

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Section: Tissue Diagnosticsmentioning

confidence: 99%

Modern trends in biophotonics for clinical diagnosis and therapy to solve unmet clinical needs

Krafft

2016

Journal of Biophotonics

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“…(73) In vivo and ex vivo studies have shown the potential of spectroscopic information compared with neoplastic with nonneoplastic tissue in BO. (74)(75)(76) Optical coherence tomography Optical coherence tomography (OCT) can provide cross sectional images of tissue structure on the micron scale in situ and in real time by measuring back scattered or back reflected light. (77) Interferometry is the technique used in OCT that measures the path length of reflected light and processes the information for image generation.…”

Section: Other Techniques: Spectroscopy Optical Coherence Tomographymentioning

confidence: 99%

Red flag imaging in Barrett's esophagus: Does it help to find the needle in the haystack?

González-Haba

Waxman

2015

Best Practice & Research Clinical Gastroenterology

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“…Endoscopic spectroscopy could certainly be used to monitor the metabolic status of the gut via fluorescence measurements (for example, of the relative fluorescence intensities or the fluorescence lifetimes of the enzymatic cofactors NADH and FAD) [78][79][80] . In addition, a variety of reflectance-based modalities (including diffuse reflectance spectroscopy 81,82 and elastic scattering spectroscopy 83 ) could enable assessment of the tissue oxygen saturation and the haemoglobin concentration.…”

Section: Microbiota Changesmentioning

confidence: 99%

The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction

Thompson

Hughes

Anastasova

et al. 2017

Nat Rev Gastroenterol Hepatol

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| Environmental enteric dysfunction (EED) is a disease of the small intestine affecting children and adults in low and middle income countries. Arising as a consequence of repeated infections, gut inflammation results in impaired intestinal absorptive and barrier function, leading to poor nutrient uptake and ultimately to stunting and other developmental limitations. Progress towards new biomarkers and interventions for EED is hampered by the practical and ethical difficulties of cross-validation with the gold standard of biopsy and histology. Optical biopsy techniques -which can provide minimally invasive or noninvasive alternatives to biopsy -could offer other routes to validation and could potentially be used as point-of-care tests among the general population. This Consensus Statement identifies and reviews the most promising candidate optical biopsy technologies for applications in EED, critically assesses them against criteria identified for successful deployment in developing world settings, and proposes further lines of enquiry. Importantly, many of the techniques discussed could also be adapted to monitor the impaired intestinal barrier in other settings such as IBD, autoimmune enteropathies, coeliac disease, graft-versus-host disease, small intestinal transplantation or critical care. Members of the board and experts met to discuss the horizon scan in London, UK, in November 2015 and San Francisco, USA, in February 2016. Literature searches were performed using Web of Science, as well as through the advice of the advisory board and experts. The results of the horizon scan are presented in this Consensus Statement, which entails a review of EED, a discussion of technologies deemed relevant to EED (based on literature searches and the opinions of the advisory board and experts), and a series of recommendations for the future application of the rele vant technologies to the study and diagnosis of EED. In the Recommendations section, each technology has been assessed according to its suitability for application to EED and this assessment includes an evaluation of the cost, invasiveness and appropriateness for developing countries of each device and/or technique. This assessment was performed in a qualitative manner based on currently available information (for example, the present cost and size of the devices) and the opinions of the authors as to feasible future develop ment. Technique suitability for use in developing countries was determined in a qualitative manner after consideration of the need for advanced infrastructure and high levels of training for either system use or data analysis. Probable deployment time scales have also been assigned to each technique based on the current states of development and the degree of valid ation work that will be required before application to EED. These timescales have been tentatively defined as short-term (suitable for deployment immediately or within ~1 year), mediumterm (suit able for deployment within ~1-3 years) and long-term (suitable for deployme...

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Diffuse reflectance spectroscopy in Barrett’s Esophagus: developing a large field‐of‐view screening method discriminating dysplasia from metaplasia

Cited by 29 publications

References 30 publications

Modern trends in biophotonics for clinical diagnosis and therapy to solve unmet clinical needs

Modern trends in biophotonics for clinical diagnosis and therapy to solve unmet clinical needs

Red flag imaging in Barrett's esophagus: Does it help to find the needle in the haystack?

The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction

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