Diffuse reflectance spectroscopy of human liver tumor specimens - towards a tissue differentiating optical biopsy needle using light emitting diodes

Keller, Alina; Białecki, Piotr; Wilhelm, T; Vetter, Marcus Klaus

doi:10.1364/boe.9.001069

Cited by 38 publications

(38 citation statements)

References 29 publications

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“…Even after the use of the most promising technique still 20% of patients need to go under re-excision surgery, showing that this problem remains unsolved up to now. It seems that for overcoming this challenge emerging technologies need to result in higher diagnostic accuracy in a more cost and time-effective way [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Intraoperative tumor margin assessment using diffuse reflectance spectroscopy: the effect of electrosurgery on tissue discrimination using ex vivo animal tissue models

Azizian¹,

Gent²,

Dankelman³

et al. 2020

Biomed. Opt. Express

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Using an intraoperative margin assessment technique during breast-conserving surgery (BCS) helps surgeons to decrease the risk of positive margin occurrence. Diffuse reflectance spectroscopy (DRS) has the potential to discriminate healthy breast tissue from cancerous tissue. We investigated the performance of an electrosurgical knife integrated with a DRS on porcine muscle and adipose tissue. Characterization of the formed debris on the optical fibers after electrosurgery revealed that the contamination is mostly burned tissue. Even with contaminated optical fibers, both tissues could still be discriminated with DRS based on fat/water ratio. Therefore, an electrosurgical knife integrated with DRS may be a promising technology to provide the surgeon with real-time guidance during BCS.

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Section: Introductionmentioning

confidence: 99%

“…Recently, researchers proved that Diffuse Reflectance Spectroscopy (DRS) has the potential to be used as a tumor margin assessment technique [12,13,[16][17][18][19][20][21][22][23][24][25]. Each tissue has its own special intrinsic light absorption and scattering for specific wavelengths which are known as "optical fingerprint".…”

Section: Introductionmentioning

confidence: 99%

Intraoperative tumor margin assessment using diffuse reflectance spectroscopy: the effect of electrosurgery on tissue discrimination using ex vivo animal tissue models

Azizian¹,

Gent²,

Dankelman³

et al. 2020

Biomed. Opt. Express

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“…73 Macroscopic methods such as reflectance spectroscopy to distinguish tumor from nontumor in needle biopsy samples are under development. 74 For CNBs, it is common even for superficial biopsies to obtain 2 or 3 cores, and for molecular studies, up to 10 passes may be required to obtain a 92% adequacy rate for lung biopsies using a 20-gauge side core needle. 75 Repeat CNBs, although uncommon, have similar adequacy rates to first biopsies.…”

Section: Adequate Sample Can Reliably Be Obtained On the First Pass Omentioning

confidence: 99%

Needle Biopsy Adequacy in the Era of Precision Medicine and Value-Based Health Care

Pritzker

Nieminen

2019

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Needle biopsy of diseased tissue is an essential diagnostic tool that is becoming even more important as precision medicine develops. However, the capability of this modality to efficiently provide samples adequate for diagnostic and prognostic analysis remains quite limited relative to current diagnostic needs. For physicians and patients, inadequate biopsy frequently leads to diagnostic delay, procedure duplication, or insufficient information about tumor biology leading to delay in treatment; for health systems, this results in substantial incremental costs and inefficient use of scarce specialized diagnostic resources. Objective.— To review current needle biopsy technology, devices, and practice with a perspective to identify current limitations and opportunities for improvement in the context of advancing precision medicine. Data Sources.— PubMed searches of fine-needle aspiration and core needle biopsy devices and similar technologies were made generally, by tissue site, and by adequacy as well as by health economics of these technologies. Conclusions.— Needle biopsy adequacy can be improved by recognizing the importance of this diagnostic tool by promoting common criteria for needle biopsy adequacy; by optimizing needle biopsy procedural technique, technologies, clinical practice, professional education, and quality assurance; and by bundling biopsy procedure costs with downstream diagnostic modalities to provide better accountability and incentives to improve the diagnostic process.

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“…The Probea has been used efficiently for detecting tumor tissues in lung and breast cancer 26 – 28 . A. Keller et al published the research on creating an optical biopsy needle to detect liver tumors by DRS 29 . F. Braun et al developed a multispectral needle probe combined with a virtual photometric setup for in vivo detection of Lewis lung carcinoma 30 .…”

Section: Introductionmentioning

confidence: 99%

Optical percutaneous needle biopsy of the liver: a pilot animal and clinical study

Dremin

Potapova

Zherebtsov

et al. 2020

Sci Rep

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This paper presents the results of the experiments which were performed using the optical biopsy system specially developed for in vivo tissue classification during the percutaneous needle biopsy (PNB) of the liver. The proposed system includes an optical probe of small diameter acceptable for use in the PNB of the liver. The results of the feasibility studies and actual tests on laboratory mice with inoculated hepatocellular carcinoma and in clinical conditions on patients with liver tumors are presented and discussed. Monte Carlo simulations were carried out to assess the diagnostic volume and to trace the sensing depth. Fluorescence and diffuse reflectance spectroscopy measurements were used to monitor metabolic and morphological changes in tissues. The tissue oxygen saturation was evaluated using a recently developed approach to neural network fitting of diffuse reflectance spectra. The Support Vector Machine Classification was applied to identify intact liver and tumor tissues. Analysis of the obtained results shows the high sensitivity and specificity of the proposed multimodal method. This approach allows to obtain information before the tissue sample is taken, which makes it possible to significantly reduce the number of false-negative biopsies.

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Diffuse reflectance spectroscopy of human liver tumor specimens - towards a tissue differentiating optical biopsy needle using light emitting diodes

Cited by 38 publications

References 29 publications

Intraoperative tumor margin assessment using diffuse reflectance spectroscopy: the effect of electrosurgery on tissue discrimination using ex vivo animal tissue models

Intraoperative tumor margin assessment using diffuse reflectance spectroscopy: the effect of electrosurgery on tissue discrimination using ex vivo animal tissue models

Needle Biopsy Adequacy in the Era of Precision Medicine and Value-Based Health Care

Optical percutaneous needle biopsy of the liver: a pilot animal and clinical study

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