Diffusion abnormalities of the corpus callosum in patients with malformations of cortical development and epilepsy

Andrade, Celi Santos; Leite, Cláudia C.; Otaduy, Maria Concepción García; Lyra, Katarina P.; Valente, Kette D.; Yasuda, Clarissa L.; Beltramini, Guilherme C.; Beaulieu, Christian; Gross, Donald

doi:10.1016/j.eplepsyres.2014.08.023

Cited by 19 publications

(24 citation statements)

References 42 publications

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“…Full text was screened in 71 cases and reference lists were inspected to detect additional studies not identified with the initial search. Forty-two studies met the inclusion criteria for the meta-analysis (Ahmadi et al, 2009, Andrade et al, 2014, Arfanakis et al, 2002, Braakman et al, 2014, Campos et al, 2015, Concha et al, 2005, Concha et al, 2007, Concha et al, 2009, Deppe et al, 2008, Diao et al, 2015, Diehl et al, 2008, Duning et al, 2010, Gao et al, 2012, Govindan et al, 2008, Gross et al, 2006, Holt et al, 2011, Hutchinson et al, 2010, Keller et al, 2011, Keller et al, 2012, Kemmotsu et al, 2011, Kemmotsu et al, 2014, Kim et al, 2011, Knake et al, 2009, Kori et al, 2013, Labate et al, 2015, Lee et al, 2013, Lee et al, 2014, Li et al, 2010, Liacu et al, 2012, Lin et al, 2008, Liu et al, 2011, Mao et al, 2011, McDonald et al, 2008, Meng et al, 2010a, Nilsson et al, 2008, Powell et al, 2007, Pustina et al, 2015, Rodrigo et al, 2007, Scanlon et al, 2013, Vulliemoz et al, 2011, Wang et al, 2010, Xiao et al, 2014). The total number of people with epilepsy and controls was 1027 and 1122, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…These findings provide new support for the hypothesis that local and remote white matter changes in focal epilepsy are – at least to some extent – a consequence of recurrent seizures, as previously suggested based on preclinical epilepsy rodent models (Otte et al, 2012b). These relationships remained inconsistent in individual human studies with smaller sample sizes (Andrade et al, 2014, Gross et al, 2006, Liu et al, 2011, Meng et al, 2010b). Our results implicate that early seizure control, pharmacologically or surgically, is important to inhibit progression of white matter alterations.…”

Section: Discussionmentioning

confidence: 99%

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White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis

Slinger

Sinke

Braun

et al. 2016

NeuroImage: Clinical

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ObjectiveSince the introduction of diffusion tensor imaging, white matter abnormalities in epilepsy have been studied extensively. However, the affected areas reported, the extent of abnormalities and the association with relevant clinical parameters are highly variable. We aimed to obtain a more consistent estimate of white matter abnormalities and their association with clinical parameters in different epilepsy types.MethodsWe systematically searched for differences in white matter fractional anisotropy and mean diffusivity, at regional and voxel level, between people with epilepsy and healthy controls. Meta-analyses were used to quantify the directionality and extent of these differences. Correlations between white matter differences and age of epilepsy onset, duration of epilepsy and sex were assessed with meta-regressions.ResultsForty-two studies, with 1027 people with epilepsy and 1122 controls, were included with regional data. Sixteen voxel-based studies were also included. People with temporal or frontal lobe epilepsy had significantly decreased fractional anisotropy (Δ –0.021, 95% confidence interval –0.026 to –0.016) and increased mean diffusivity (Δ0.026 × 10–3 mm2/s, 0.012 to 0.039) in the commissural, association and projection white matter fibers. White matter was much less affected in generalized epilepsy. White matter changes in people with focal epilepsy correlated with age at onset, epilepsy duration and sex.SignificanceThis study provides a better estimation of white matter changes in different epilepsies. Effects are particularly found in people with focal epilepsy. Correlations with the duration of focal epilepsy support the hypothesis that these changes are, at least partly, a consequence of seizures and may warrant early surgery. Future studies need to guarantee adequate group sizes, as white matter differences in epilepsy are small.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis

Slinger

Sinke

Braun

et al. 2016

NeuroImage: Clinical

View full text Add to dashboard Cite

show abstract

“…Hermann et al identified a similar pattern of corpus callosum changes in individuals with early onset temporal lobe epilepsy, with more severe posterior changes than anterior changes compared with both healthy controls and late onset cases (Hermann, Hansen et al 2003). A recently published diffusion imaging study that investigated corpus callosum changes in individuals with malformations of cortical development did not identify a relationship between corpus callosum diffusion changes and age of epilepsy onset or epilepsy duration, which they interpreted as suggesting a developmental origin for corpus callosum changes (Andrade, Leite et al 2014). …”

Section: Discussionmentioning

confidence: 98%

Quantitative assessment of corpus callosum morphology in periventricular nodular heterotopia

et al. 2015

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We investigated systematic differences in corpus callosum morphology in periventricular nodular heterotopia (PVNH). Differences in corpus callosum mid-sagittal area and subregional area changes were measured using an automated software-based method. Heterotopic gray matter deposits were automatically labeled and compared with corpus callosum changes. The spatial pattern of corpus callosum changes were interpreted in the context of the characteristic anterior-posterior development of the corpus callosum in healthy individuals. Individuals with periventricular nodular heterotopia were imaged at the Melbourne Brain Center or as part of the multi-site Epilepsy Phenome Genome project. Whole brain T1 weighted MRI was acquired in cases (n = 48) and controls (n = 663). The corpus callosum was segmented on the mid-sagittal plane using the software “yuki”. Heterotopic gray matter and intracranial brain volume was measured using Freesurfer. Differences in corpus callosum area and subregional areas were assessed, as well as the relationship between corpus callosum area and heterotopic GM volume. The anterior-posterior distribution of corpus callosum changes and heterotopic GM nodules were quantified using a novel metric and compared with each other. Corpus callosum area was reduced by 14% in PVNH (p = 1.59 × 10−9). The magnitude of the effect was least in the genu (7% reduction) and greatest in the isthmus and splenium (26% reduction). Individuals with higher heterotopic GM volume had a smaller corpus callosum. Heterotopic GM volume was highest in posterior brain regions, however there was no linear relationship between the anterior-posterior position of corpus callosum changes and PVNH nodules. Reduced corpus callosum area is strongly associated with PVNH, and is probably associated with abnormal brain development in this neurological disorder. The primarily posterior corpus callosum changes may inform our understanding of the etiology of PVNH. Our results suggest that interhemispheric pathways are affected in PVNH.

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“…It has been demonstrated changes in several WM tracts -e.g., cingulum, fornix, uncinate fasciculus, superior and inferior longitudinal fasciculi -in distinct epilepsy syndromes, such as mesial temporal sclerosis and juvenile myoclonic epilepsy [7]. Recently, diffusion abnormalities of the corpus callosum have also been demonstrated in MCD patients, including individuals diagnosed with PMG [8].…”

Section: Introductionmentioning

confidence: 98%

DTI-based tractography of the arcuate fasciculus in patients with polymicrogyria and language disorders

Andrade

Figueiredo

Valeriano

et al. 2015

European Journal of Radiology

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Diffusion abnormalities of the corpus callosum in patients with malformations of cortical development and epilepsy

Cited by 19 publications

References 42 publications

White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis

White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis

Quantitative assessment of corpus callosum morphology in periventricular nodular heterotopia

DTI-based tractography of the arcuate fasciculus in patients with polymicrogyria and language disorders

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