Diffusion-kurtosis imaging predicts early radiotherapy response in nasopharyngeal carcinoma patients

Wu, Gang; Li, Mengmeng; Chen, Feng; Lin, S.; Yang, Kai; Ying-man, Zhao; Zhu, Xiaolei; Huang, Weiyuan; Li, Jianjun

doi:10.18632/oncotarget.19820

Cited by 2 publications

(1 citation statement)

References 36 publications

(51 reference statements)

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“…Our preliminary study (patient cohort, number = 31) demonstrated that DKI could be a noninvasive tool to predict the early response to radiotherapy in NPC patients 14 . Then, based on our preliminary study, we continue to collect patients.…”

Section: Discussionmentioning

confidence: 91%

In Vivo Imaging Markers for Prediction of Radiotherapy Response in Patients with Nasopharyngeal Carcinoma: RESOLVE DWI versus DKI

Huang

Lin

et al. 2018

Sci Rep

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In this prospective study, we compared the performance of readout segmentation of long variable echo trains of diffusion-weighted imaging (RESOLVE DWI) and diffusion kurtosis imaging (DKI) for the prediction of radiotherapy response in patients with nasopharyngeal carcinoma (NPC). Forty-one patients with NPC were evaluated. All patients underwent conventional MRI, RESOLVE DWI and DKI, before and after radiotherapy. All patients underwent conventional MRI every 3 months until 1 year after radiotherapy. The patients were divided into response group (RG; 36/41 patients) and no-response group (NRG; 5/41 patients) based on follow-up results. DKI (the mean of kurtosis coefficient, Kmean and the mean of diffusion coefficient, Dmean) and RESOLVE DWI (the minimum apparent diffusion coefficient, ADCmin) parameters were calculated. Parameter values at the pre-treatment period, post-treatment period, and the percentage change between these 2 periods were obtained. All parameters differed between the RG and NRG groups except for the pretreatment Dmean and ADCmin. Kmean-post was considered as an independent predictor of local control, with 87.5% sensitivity and 91.3% specificity (optimal threshold = 0.30, AUC: 0.924; 95% CI, 0.83–1.00). Kmean-post values of DKI have the potential to be used as imaging biomarkers for the early evaluation of treatment effects of radiotherapy on NPC.

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Section: Discussionmentioning

confidence: 91%

In Vivo Imaging Markers for Prediction of Radiotherapy Response in Patients with Nasopharyngeal Carcinoma: RESOLVE DWI versus DKI

Huang

Lin

et al. 2018

Sci Rep

Self Cite

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Optimization of scan parameters to reduce acquisition time for RESOLVE-based diffusion kurtosis imaging (DKI) in nasopharyngeal carcinoma (NPC)

Chen

Zhang

et al. 2022

The British Journal of Radiology

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Objectives: To shorten acquisition time of readout segmentation of long variable echo trains (RESOLVE)-based diffusion kurtosis imaging (DKI) via Readout Partial Fourier (RPF) and b-value combinations. Methods: The RESOLVE-based DKI images of 38 patients with nasopharyngeal carcinoma (NPC) were prospectively enrolled. For RESOLVE-based DKI images with 5/8 RPF and without RPF, objective and subjective evaluations of image quality were performed. A total of nine groups with different b-value combinations were simulated, and the influence of different b-value combinations for RESOLVE-RPF-based DKI sequences was assessed using the intraclass correlation coefficient (ICC). Results: The mean values of signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) in DKI images without RPF were higher than those with 5/8 RPF (252.9 ± 77.7 vs 247.3 ± 85.5 and 5.8 ± 2.8 vs 5.4 ± 2.3, respectively), but not significantly (p = 0.460 and p = 0.180, respectively). In comparing the ICCs between nine groups of different b-value combinations in RESOLVE-RPF-based DKI, group (200, 800, 2000 s/mm2), group (200, 400, 800, 2000 s/mm2) and group (200, 800, 1500, 2000 s/mm2) were not significantly different (p > 0.001) and showed excellent agreement (0.81–1.00) with that of group (200, 400, 800, 1500, 2000 s/mm2). Using b-value optimization and RPF technology, the group with RPF (200, 400, 800, 2000 s/mm2) showed a 56% reduced scanning compared with the group without RPF (200, 400, 800, 1500, 2000 s/mm2; 3 min 46 s vs 8 min 31 s, respectively). Conclusions: DKI with RPF did not significantly affect image quality, but both RPF and different b-value combinations can affect the scanning time. The combination of RPF and b-value optimization can ensure the stability of DKI parameters and reduce the scanning time by 56%. Advances in knowledge: This work is to optimize scan parameters, e.g., RPF and b-value combinations, to reduce acquisition time for RESOLVE-based DKI in NPC. To our knowledge, the effect of RESOLVE-RPF and b-value combinations on DKI has not been reported.

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Diffusion-kurtosis imaging predicts early radiotherapy response in nasopharyngeal carcinoma patients

Cited by 2 publications

References 36 publications

In Vivo Imaging Markers for Prediction of Radiotherapy Response in Patients with Nasopharyngeal Carcinoma: RESOLVE DWI versus DKI

In Vivo Imaging Markers for Prediction of Radiotherapy Response in Patients with Nasopharyngeal Carcinoma: RESOLVE DWI versus DKI

Optimization of scan parameters to reduce acquisition time for RESOLVE-based diffusion kurtosis imaging (DKI) in nasopharyngeal carcinoma (NPC)

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