Diffusion MRI: Pitfalls, literature review and future directions of research in mild traumatic brain injury

Delouche, Aurélie; Attyé, Arnaud; Heck, Olivier; Grand, Sylvie; Kastler, Adrian; Lamalle, Laurent; Renard, Félix; Krainik, Alexandre

doi:10.1016/j.ejrad.2015.11.004

Cited by 44 publications

(33 citation statements)

References 58 publications

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“…In accordance with neuroimaging for TBI,35 different protocols were applied to study structural (diffusion tensor imaging (DTI),36 voxel-based MR morphometry (VBM)) and metabolic (functional MRI (fMRI), magnetic resonance spectroscopy (MRS)) brain changes in football players and to correlate with neurocognitive function. In two small case–control studies, memory impairment was linked to cortical thinning in former professionals37 and to diffuse white matter abnormalities in amateur players,17 while recently in a prospective case–control study over 5 years in professional players, no such link could be drawn 38…”

Section: Introductionmentioning

confidence: 99%

Persistent effects of playing football and associated (subconcussive) head trauma on brain structure and function: a systematic review of the literature

et al. 2016

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Various methodological shortcomings limit the evidence for persistent effects of football play on brain structure/function. Sources of bias include low-quality assessment of heading frequency, inappropriate control for type 1 errors and inappropriate selection of controls. Combining neuroimaging techniques with neurocognitive testing in prospective studies seems most promising to further clarify on the impact of football on the brain.

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Section: Introductionmentioning

confidence: 99%

Persistent effects of playing football and associated (subconcussive) head trauma on brain structure and function: a systematic review of the literature

et al. 2016

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“…Both approaches have further refined our understanding of the localized and neural underpinnings of healthy and disrupted sleep, as well as of circadian variations in brain functions [68][69][70]. The use of neuroimaging methods such as positron emission tomography and structural and functional magnetic resonance imaging during sleep and wakefulness in concussed, recovered, and never concussed individuals remain scarce, but has a high potential to provide unique and novel insights into the underpinnings of sleep and circadian disturbances in mTBI, and therefore may guide the development of innovative and targeted diagnostic and therapeutic strategies [70][71][72][73][74][75].…”

Section: Advanced Sleep Measurement Methodsmentioning

confidence: 99%

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

et al. 2016

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Disturbed sleep is one of the most common complaints following traumatic brain injury (TBI) and worsens morbidity and long-term sequelae. Further, sleep and TBI share neurophysiologic underpinnings with direct relevance to recovery from TBI. As such, disturbed sleep and clinical sleep disorders represent modifiable treatment targets to improve outcomes in TBI. This paper presents key findings from a national working group on sleep and TBI, with a specific focus on the testing and development of sleep-related therapeutic interventions for mild TBI (mTBI). First, mTBI and sleep physiology are briefly reviewed. Next, essential empirical and clinical questions and knowledge gaps are addressed. Finally, actionable recommendations are offered to guide active and efficient collaboration between academic, industry, and governmental stakeholders.

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“…One of the more advanced modes of MRI currently is diffusion tensor imaging (DT-MRI). It traces the direction of water molecules’ diffusion and uses computed parameters of diffusivity as measures of axonal integrity (Delouche et al, 2016). The technique allows for accurate 3D modeling of neural tracts (tractography) by means of computerized image analysis.…”

Section: Introductionmentioning

confidence: 99%

Biomarkers of Traumatic Brain Injury: Temporal Changes in Body Fluids

Harel¹,

Kvist²,

Salla³

et al. 2016

eNeuro

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Traumatic brain injuries (TBIs) are caused by a hit to the head or a sudden acceleration/deceleration movement of the head. Mild TBIs (mTBIs) and concussions are difficult to diagnose. Imaging techniques often fail to find alterations in the brain, and computed tomography exposes the patient to radiation. Brain-specific biomolecules that are released upon cellular damage serve as another means of diagnosing TBI and assessing the severity of injury. These biomarkers can be detected from samples of body fluids using laboratory tests. Dozens of TBI biomarkers have been studied, and research related to them is increasing. We reviewed the recent literature and selected 12 biomarkers relevant to rapid and accurate diagnostics of TBI for further evaluation. The objective was especially to get a view of the temporal profiles of the biomarkers’ rise and decline after a TBI event. Most biomarkers are rapidly elevated after injury, and they serve as diagnostics tools for some days. Some biomarkers are elevated for months after injury, although the literature on long-term biomarkers is scarce. Clinical utilization of TBI biomarkers is still at a very early phase despite years of active research.

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Diffusion MRI: Pitfalls, literature review and future directions of research in mild traumatic brain injury

Cited by 44 publications

References 58 publications

Persistent effects of playing football and associated (subconcussive) head trauma on brain structure and function: a systematic review of the literature

Persistent effects of playing football and associated (subconcussive) head trauma on brain structure and function: a systematic review of the literature

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

Biomarkers of Traumatic Brain Injury: Temporal Changes in Body Fluids

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