Diffusion tensor imaging in elderly patients with idiopathic normal pressure hydrocephalus or Parkinson’s disease: diagnosis of gait abnormalities

Marumoto, Kohei; Koyama, Tetsuo; Hosomi, Masashi; Kodama, Norihiko; Miyake, Hiroji; Domen, Kazuhisa

doi:10.1186/2045-8118-9-20

Cited by 37 publications

(54 citation statements)

References 38 publications

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“…9,16,41,45,48,55,57,59,75,84,94,125 Understanding the periventricular white matter tracts is helpful not only in defining more precise surgical strategies, but also in clarifying the symptoms of and appropriate treatment for patients with hydrocephalus and periventricular lesions. 11,18,36,38,40,47,50,52,58,65,66,76,80,101 This study examines the tracts at risk in the 3 surgical routes-anterior, posterior, and lateral-to the lateral ventricle. The anterior approaches include the anterior interhemispheric transcallosal, anterior frontal transcortical, and anterior frontal interhemispheric transrostral; the posterior approaches include the posterior transcortical (superior parietal lobule), posterior interhemispheric transcallosal, posterior interhemispheric precuneal, supracere- …”

Section: Discussionmentioning

confidence: 99%

“…40,47,66,80 Recent studies have reported lower FA in NPH than in AD or PD in the corpus callosum. 65,66 Mataró et al and Hoza et al showed a negative correlation between the size of the frontal fibers of the corpus callosum and mild impairment of attention and executive function in idiopathic NPH.…”

Section: 58mentioning

confidence: 99%

“…50 Decompression of the anterior part of the corona radiata, which contains fibers that connect to the supplementary motor, primary motor, and sensory areas, has been shown to improve gait disturbance. 50,65 Cognitive decline and incontinence also fit with impairment of the anterior part of the corona radiata. 40 …”

Section: Corona Radiatamentioning

confidence: 99%

“…MR tractography has been recommended as a means of differentiating among NPH, AD, and PD. 36,38,40,47,50,52,65,66,76 Hydrocephalus studies have suggested that the compression indicated by high fractional anisotropy (FA) levels will eventually cause the neuronal degeneration, brain edema, or deterioration of the white matter indicated by low FA levels.…”

Section: Periventricular Tracts In Hydrocephalusmentioning

confidence: 99%

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The white matter tracts of the cerebrum in ventricular surgery and hydrocephalus

Güngör¹,

Baydın²,

Middlebrooks

et al. 2017

JNS

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S urgical approaches to the lateral ventricle always require passage through one and often multiple fiber tracts to reach their target. These approaches remain a challenge because of the deep location and variable shape and size of the ventricles, their covering mantle of tracts, and relationships to important neural structures such as the thalamus and internal capsule. 55,75,84 In addition, a number of tracts course in the walls of the ventricle where they are separated from the cerebrospinal fluid by only a thin layer of ependyma and would likely be exposed to the greatest possibility of damage by hydrocephalus.84,124 Recent studies have focused on the relationships of the fiber tracts to eloquent cortical areas and avoiding the optic radiations in approaches to the lateral ventricle. 16,41,48,59,63,75,89,92,94,125 The aim of the present study was to explore the relationships of the tracts to the lateral ventricles and the various surgical approaches to the ventricles and to examine the anatomy and syndromes related to ventricular enlargement. MethodsForty adult human formalin-fixed cadaveric hemispheres (20 brains) were examined under magnification that ranged from ×6 to ×40. The dura, pia, arachnoid, and surface vessels were gently removed. All specimens were frozen in water for at least 2 weeks at -16°C, as described by Klingler, to separate the tracts and facilitate dissection. 51 After freezing, the specimens were thawed and rinsed of formalin under tap water for at least 1 hour. Prior OBJECTIVEThe relationship of the white matter tracts to the lateral ventricles is important when planning surgical approaches to the ventricles and in understanding the symptoms of hydrocephalus. The authors' aim was to explore the relationship of the white matter tracts of the cerebrum to the lateral ventricles using fiber dissection technique and MR tractography and to discuss these findings in relation to approaches to ventricular lesions. METHODS Forty adult human formalin-fixed cadaveric hemispheres (20 brains) and 3 whole heads were examined using fiber dissection technique. The dissections were performed from lateral to medial, medial to lateral, superior to inferior, and inferior to superior. MR tractography showing the lateral ventricles aided in the understanding of the 3D relationships of the white matter tracts with the lateral ventricles. RESULTS The relationship between the lateral ventricles and the superior longitudinal I, II, and III, arcuate, vertical occipital, middle longitudinal, inferior longitudinal, inferior frontooccipital, uncinate, sledge runner, and lingular amygdaloidal fasciculi; and the anterior commissure fibers, optic radiations, internal capsule, corona radiata, thalamic radiations, cingulum, corpus callosum, fornix, caudate nucleus, thalamus, stria terminalis, and stria medullaris thalami were defined anatomically and radiologically. These fibers and structures have a consistent relationship to the lateral ventricles. CONCLUSIONS Knowledge of the relationship of the white matter tracts o...

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Section: Discussionmentioning

confidence: 99%

Section: 58mentioning

confidence: 99%

Section: Corona Radiatamentioning

confidence: 99%

Section: Periventricular Tracts In Hydrocephalusmentioning

confidence: 99%

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The white matter tracts of the cerebrum in ventricular surgery and hydrocephalus

Güngör¹,

Baydın²,

Middlebrooks

et al. 2017

JNS

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“…24 Marumoto and others investigated FA in 5 different brain regions in 10 iNPH patients, 18 PD patients, and 10 healthy controls. 37 According to this study, FA in the anterior thalamic radiation and the minor forceps was lower in iNPH patients than in the PD patients. Moreover, FA in the anterior thalamic radiation was statistically significantly associated with gait disturbances in both patient groups.…”

mentioning

confidence: 99%

The role of diffusion tensor imaging and fractional anisotropy in the evaluation of patients with idiopathic normal pressure hydrocephalus: a literature review

Siasios

Kapsalaki²,

Fountas³

et al. 2016

FOC

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OBJECTIVE Diffusion tensor imaging (DTI) for the assessment of fractional anisotropy (FA) and involving measurements of mean diffusivity (MD) and apparent diffusion coefficient (ADC) represents a novel, MRI-based, noninvasive technique that may delineate microstructural changes in cerebral white matter (WM). For example, DTI may be used for the diagnosis and differentiation of idiopathic normal pressure hydrocephalus (iNPH) from other neurodegenerative diseases with similar imaging findings and clinical symptoms and signs. The goal of the current study was to identify and analyze recently published series on the use of DTI as a diagnostic tool. Moreover, the authors also explored the utility of DTI in identifying patients with iNPH who could be managed by surgical intervention. METHODS The authors performed a literature search of the PubMed database by using any possible combinations of the following terms: “Alzheimer's disease,” “brain,” “cerebrospinal fluid,” “CSF,” “diffusion tensor imaging,” “DTI,” “hydrocephalus,” “idiopathic,” “magnetic resonance imaging,” “normal pressure,” “Parkinson's disease,” and “shunting.” Moreover, all reference lists from the retrieved articles were reviewed to identify any additional pertinent articles. RESULTS The literature search retrieved 19 studies in which DTI was used for the identification and differentiation of iNPH from other neurodegenerative diseases. The DTI protocols involved different approaches, such as region of interest (ROI) methods, tract-based spatial statistics, voxel-based analysis, and delta-ADC analysis. The most studied anatomical regions were the periventricular WM areas, such as the internal capsule (IC), the corticospinal tract (CST), and the corpus callosum (CC). Patients with iNPH had significantly higher MD in the periventricular WM areas of the CST and the CC than had healthy controls. In addition, FA and ADCs were significantly higher in the CST of iNPH patients than in any other patients with other neurodegenerative diseases. Gait abnormalities of iNPH patients were statistically significantly and negatively correlated with FA in the CST and the minor forceps. Fractional anisotropy had a sensitivity of 94% and a specificity of 80% for diagnosing iNPH. Furthermore, FA and MD values in the CST, the IC, the anterior thalamic region, the fornix, and the hippocampus regions could help differentiate iNPH from Alzheimer or Parkinson disease. Interestingly, CSF drainage or ventriculoperitoneal shunting significantly modified FA and ADCs in iNPH patients whose condition clinically responded to these maneuvers. CONCLUSIONS Measurements of FA and MD significantly contribute to the detection of axonal loss and gliosis in the periventricular WM areas in patients with iNPH. Diffusion tensor imaging may also represent a valuable noninvasive method for differentiating iNPH from other neurodegenerative diseases. Moreover, DTI can detect dynamic changes in the WM tracts after lumbar drainage or shunting procedures and could help identify iNPH patients who may benefit from surgical intervention.

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Sphingolipid abnormalities in encephalomyeloradiculoneuropathy (EMRN) are associated with an anti‐neutral glycolipid antibody

2023

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Accumulating evidence suggests that various sphingolipids and glycosphingolipids can act as mediators for inflammation or signaling molecules in the nervous system. In this article, we explore the molecular basis of a new neuroinflammatory disorder called encephalomyeloradiculoneuropathy (EMRN), which affects the brain, spinal cord, and peripheral nerves; in particular, we discuss whether glycolipid and sphingolipid dysmetabolism is present in patients with this disorder. This review will focus on the pathognomonic significance of sphingolipid and glycolipid dysmetabolism for the development of EMRN and the possible involvement of inflammation in the nervous system.

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Diffusion tensor imaging in elderly patients with idiopathic normal pressure hydrocephalus or Parkinson’s disease: diagnosis of gait abnormalities

Cited by 37 publications

References 38 publications

The white matter tracts of the cerebrum in ventricular surgery and hydrocephalus

The white matter tracts of the cerebrum in ventricular surgery and hydrocephalus

The role of diffusion tensor imaging and fractional anisotropy in the evaluation of patients with idiopathic normal pressure hydrocephalus: a literature review

Sphingolipid abnormalities in encephalomyeloradiculoneuropathy (EMRN) are associated with an anti‐neutral glycolipid antibody

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