Diffusion tensor imaging of prostate at 3.0 Tesla

Abstract

ADC and FA values of normal prostate may be compatible with the microstructural organization of prostate. Furthermore, DTI may be a potential tool in diagnosing prostate cancer in the peripheral zone.

Correlation of gleason scores with magnetic resonance diffusion tensor imaging in peripheral zone prostate cancer

“…This finding suggests that DTI can have discriminatory value in addition to T2WI for multiparametic prostate MRI. Combined MRI and DTI has been shown to aid in tumor localization within the peripheral zone, and preliminary reports of DTI assessment of tumor aggressiveness have shown promise . DTI can also provide a “trace” of the high b‐value component, which along with the ADC map can be analyzed using the upcoming 2 nd version of prostate imaging reporting and data system (PI‐RADS V2) diffusion‐weighted imaging assessment criteria.…”

“…However, routine MRI sequences, including T1‐ and T2‐weighted imaging, have relatively moderate sensitivity (67–81%) and specificity (46–69%) for the diagnosis of PCa . Recently, the clinical application of diffusion tensor imaging (DTI) of the prostate has been confirmed by several studies . DTI can provide both apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values, which may reflect physiological features and pathological changes at the microscopic level.…”

Diffusion tensor imaging in abdominal organs

“…However, the FA‐values reported in the literature for the central and peripheral zone of unaffected prostate are very heterogeneous (Table ). While some other authors have consistently demonstrated a higher FA in the central zone than in the peripheral zone , other authors reported higher FA in the peripheral zone than in the central zone or equal FA‐values between the peripheral and central zones . Similarly to DTI in other anatomical regions, these variations might be attributed to several factors, including differences in imaging parameters ( T R / T E ), b ‐values, SNRs, field strengths or encoding directions.…”

“…The most interesting application of DTI in the prostate is the detection and characterization of cancerous lesions, as it might provide distinct information on tissue microstructure. Recent studies on DTI in prostate cancer have shown conflicting results (87,91,92,(94)(95)(96)(97)(98)(99)(100). Compared with normal prostate tissue, studies have reported higher, lower or equal FA for prostate cancer ( Table 2).…”

Diffusion-weighted and diffusion-tensor imaging of normal and diseased uterus

“…Although not clearly proved like DWI (low ADC in malignant tumors), quantitative DTI also reveals difference in the FA value of benign vs malignant tissue, however statistical significance can be much more less detected. Besides there is confusion regarding FA value alterations which should be evaluated with further studies [2,38,39] .…”