Diffusion Tensor Imaging of the Calf Muscles in Subjects With and Without Diabetes Mellitus

Edalati, Masoud; Hastings, Mary K.; Sorensen, Christopher J.; Zayed, Mohamed A.; Mueller, Michael J.; Hildebolt, Charles F.; Zheng, Jie

doi:10.1002/jmri.26286

Cited by 11 publications

(7 citation statements)

References 39 publications

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“…Changes in the water diffusion properties of skeletal muscles have been observed in relation to physiologic changes (age, sex, and exercise) and pathologic changes (ischemia, denervation, trauma, and inflammation) (14,15). DTI studies of skeletal muscle in patients with type 2 diabetes mellitus (DM2) are limited; however, Edalati et al report diffusion differences in plantar flexors when compared with those in healthy participants (16).…”

Section: Key Resultsmentioning

confidence: 99%

“…DTI has proven sensitive to reflect muscle alterations in neuromuscular disorders, particularly in Duchenne muscular dystrophy, indicated by higher MD or apparent diffusion coefficients and lower FA values, when compared when compared with healthy participants (10,35). A recent study evaluated the microstructure of plantar flexors of participants with DM2 during isometric contraction and reported a greater elevation in MD from rest to plantar flexion compared with healthy muscles (16). This could indicate that microstructural changes assessed inclusion of participants with DM2 with a more severe degree of neuropathy will enable validation of our results.…”

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confidence: 99%

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MRI of Skeletal Muscles in Participants with Type 2 Diabetes with or without Diabetic Polyneuropathy

Stouge¹,

Khan²,

Kristensen³

et al. 2020

Radiology

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Section: Key Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

MRI of Skeletal Muscles in Participants with Type 2 Diabetes with or without Diabetic Polyneuropathy

Stouge¹,

Khan²,

Kristensen³

et al. 2020

Radiology

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“…26,29,[33][34][35][36][37][38] Diffusion-weighted images (DWI) were acquired using a STEAM prototype sequence with an echoplanar imaging (EPI) readout 39 with spectral adiabatic inversion recovery fat suppression: TR/ TE: 6300 ms/42. 4…”

Section: Mr Measurementsmentioning

confidence: 99%

“…There is growing evidence supporting the use of diffusion tensor imaging (DTI) in skeletal muscle. DTI measurements have been shown to be sensitive to muscle changes due to myositis, [1][2][3] diabetes mellitus, 4 muscle injury, 5,6 exercise [7][8][9] and ageing. 10 The majority of these studies use spin echo DTI; however there are advantages in using a stimulated echo acquisition mode (STEAM) approach.…”

Section: Introductionmentioning

confidence: 99%

Normal values and test–retest variability of stimulated-echo diffusion tensor imaging and fat fraction measurements in the muscle

Farrow

Grainger

Tan

et al. 2019

The British Journal of Radiology

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Objectives: To assess the test–retest variability of both diffusion parameters and fat fraction (FF) estimates in normal muscle, and to assess differences in normal values between muscles in the thigh. Methods: 29 healthy volunteers (mean age 37 years, range 20–60 years, 17/29 males) completed the study. Magnetic resonance images of the mid-thigh were acquired using a stimulated echo acquisition mode-echoplanar imaging (STEAM-EPI) imaging sequence, to assess diffusion, and 2-point Dixon imaging, to assess FF. Imaging was repeated in 19 participants after a 30 min interval in order to assess test–retest variability of the measurements. Results: Intraclass correlation coefficients (ICCs) for test–retest variability were 0.99 [95% confidence interval, (CI): 0.98, 1] for FF, 0.94 (95% CI: 0.84, 0.97) for mean diffusivity and 0.89 (95% CI: 0.74, 0.96) for fractional anisotropy (FA). FF was higher in the hamstrings than the quadriceps by a mean difference of 1.81% (95% CI:1.63, 2.00)%, p < 0.001. Mean diffusivity was significantly lower in the hamstrings than the quadriceps (0.26 (0.13, 0.39) x10-3 mm2s−1, p < 0.001) whereas fractional anisotropy was significantly higher in the hamstrings relative to the quadriceps with a mean difference of 0.063 (0.05, 0.07), p < 0.001. Conclusions: This study has shown excellent test-retest, variability in MR-based FF and diffusion measurements and demonstrated significant differences in these measures between hamstrings and quadriceps in the healthy thigh. Advances in knowledge: Test–retest variability is excellent for STEAM-EPI diffusion and 2-point Dixon-based FF measurements in the healthy muscle. Inter- and intraobserver variability were excellent for region of interest placement for STEAM-EPI diffusion and 2-point Dixon-based FF measurements in the healthy muscle. There are significant differences in FF and diffusion measurements between the hamstrings and quadriceps in the normal muscle.

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“…It can be speculated that a decrease in VI muscle activity due to IMAT might be compensated by an increase in VL muscle activity. Some studies showed that higher λ 1–3 values were observed in nonathletes (vs. athletes), 24 females (vs. males), 8 and people with diabetes mellitus (vs. healthy people), 25 from which we speculate that the higher λ 1–3 values may be caused by larger percentages of IMAT. However, the present study showed that the QM IMAT percentage had no statistically significant relationships with any water diffusivities, whereas the infiltration direction of the IMAT differed in the individual QMs, and the relationships between IMAT and the water diffusivities were strongest in the VM.…”

Section: Discussionmentioning

confidence: 62%

The Relationship Between Quadriceps Femoris Muscle Function and MRI‐Derived Water Diffusion and Adipose Tissue Measurements in Young Healthy Males

Yamauchi¹,

Someya²,

Kato³

et al. 2022

Magnetic Resonance Imaging

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Background Water diffusion and adipose tissue in a muscle can be evaluated by MRI. However, determining which quadriceps femoris muscle (QM) characteristics independently predict peak knee extension torque during maximum voluntary isometric contractions (MVICs), individual muscle activity during MVICs and sit‐to‐stand transitions is unknown. Purpose To determine which QM characteristics predict knee extension muscle strength and individual muscle activity. Study Type Prospective, cross‐sectional. Subjects A total of 20 healthy males (aged 22–40 years) with a physical activity level <1 hour/week. Field Strength/Sequence 1.5‐T, diffusion‐weighted fast spin–echo echo‐planar imaging and T1‐weighted fast spin–echo sequences. Assessment The vastus medialis (VM), vastus lateralis (VL), rectus femoris (RF), and vastus intermedius were segmented in a single axial diffusion‐weighted image and T1‐weighted image at the right mid‐thigh region. λ1–3 and fractional anisotropy (FA), and the percentage of intramuscular adipose tissue (IMAT) were measured. The knee extension peak force during MVICs was measured by a dynamometer, and the torque was calculated at the peak force × length. The ratios of the individual muscle activity to the total muscle (VM, VL, and RF) during MVICs and sit‐to‐stand transitions were assessed using surface electromyography. Statistical Tests Regression analysis was conducted to identify the predictors of peak knee extension torque and of individual muscle activity ratios. A P value < 0.05 was considered statistically significant. Results The RF λ1 significantly predicted the peak knee extension torque (β = −0.51). The IMAT percentage of the VM significantly predicted the VM muscle activity ratio during the MVIC and sit‐to‐stand transition (β = −0.82 and β = −0.61, respectively), whereas the ratio of the VM λ1 to the whole QM λ1 significantly predicted the VM muscle activity ratio during the sit‐to‐stand transitions (β = 0.35 and β = 0.46, respectively). Data Conclusion The RF λ1 may allow to estimate peak knee extension muscle torque, and the VM IMAT and λ1 may predict muscle activity in youth. Evidence Level 3. Technical Efficacy Stage 3.

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Diffusion Tensor Imaging of the Calf Muscles in Subjects With and Without Diabetes Mellitus

Abstract: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018.

Cited by 11 publications

References 39 publications

MRI of Skeletal Muscles in Participants with Type 2 Diabetes with or without Diabetic Polyneuropathy

MRI of Skeletal Muscles in Participants with Type 2 Diabetes with or without Diabetic Polyneuropathy

Normal values and test–retest variability of stimulated-echo diffusion tensor imaging and fat fraction measurements in the muscle

The Relationship Between Quadriceps Femoris Muscle Function and MRI‐Derived Water Diffusion and Adipose Tissue Measurements in Young Healthy Males

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