Diffusion Tensor Magnetic Resonance Imaging in Patients with Multiple Sclerosis and its Relationship with Disability

Temel, Şadiye; Kekliğkoğlu, H.D.; Vural, Gönül; Denız, Orhan; Ercan, Karabekir

doi:10.1177/197140091302600101

Cited by 11 publications

(10 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Concerning the spinal cord, the present study agreed with previous DTI studies of the spinal cord in MS patients reported a statistically significant FA difference between the control group and the MS patient group [3,[7][8][9][10][11]. Chen et al [7] stated that the decrease in the FA value of NAWM and the increase in MD value as compared to normal controls indicate the presence of occult damage to the NAWM.…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Diffusion tensor imaging for assessment of normally appearing white matter of the brain and spinal cord in cases of multiple sclerosis: a multi-parametric correlation in view of patient’s clinical status

ElSayed¹,

Eltoukhy

Asaad

et al. 2019

Egypt J Radiol Nucl Med

View full text Add to dashboard Cite

Background: Conventional MRI provides important morphologic information regarding the brain and spinal cord involvement by demyelinating plaques. However, it is of almost no value in assessing the normal-appearing white matter which has been proved by multiple pathologic studies to be directly and indirectly involved in the process of multiple sclerosis. Diffusion-weighted imaging and diffusion tensor imaging MRI have been widely used in multiple researches as a better solution for studying the normal-appearing white matter. The purpose of this study was to evaluate the role of diffusion tensor imaging examination of the normal-appearing white matter of the brain and spinal cord in patients with multiple sclerosis and to determine the relationship between diffusion tensor imaging metrics and patient's clinical status. Results: The significant negative correlation found between expanded disability status scale score of secondary progressive MS patients and global (brain and spinal cord) average fractional anisotropy values in normal-appearing white matter and tracts (P = 0.000). Correlation between average apparent diffusion coefficient of corpus callosum tract and expanded disability status scale score revealed a significant positive correlation in RRMS (P = 0.001). While in secondary progressive MS, a significant negative correlation between fractional anisotropy average of the corpus callosum tract and expanded disability status scale score was noted (P = 0.015). Conclusion: There is a strong relationship between diffusion tensor imaging readings and clinical status of patients can be used to understand unexplained deterioration over disease course and also can be used when conventional MRI findings are equivocal. Corpus callosum affection in MS patients is intimately related to clinical status and its assessment should be done whenever possible.

show abstract

Section: Discussionsupporting

confidence: 90%

“…Temel et al [11] showed that mean fiber ADC value was statistically significantly higher than that in the control group.…”

Section: Discussionmentioning

confidence: 93%

Diffusion tensor imaging for assessment of normally appearing white matter of the brain and spinal cord in cases of multiple sclerosis: a multi-parametric correlation in view of patient’s clinical status

ElSayed¹,

Eltoukhy

Asaad

et al. 2019

Egypt J Radiol Nucl Med

View full text Add to dashboard Cite

show abstract

“…R 1 is sensitive to inflammatory and demyelinating processes 9 and is decreased in normalappearing white matter (NAWM) in MS. 10,11 MTR may predict cognitive deterioration in MS, 12,13 and has been shown to be relatively stable, 14,15 although one study needed to "normalize" MTR. 6 The association of DWI metrics with MS has been variable, ranging from high 16 to nonexistent, 17 although sensitivity for lesion detection is high. 18 rsFMRI has been the most variable of the four with respect to studies of MS, reporting decreases 19 and increases 20,21 in MS patients relative to controls, although a recent report found strong correlations with well-established disability assessment tools.…”

mentioning

confidence: 99%

Multisite reliability and repeatability of an advanced brain MRI protocol

Schwartz

Tagge

Powers

et al. 2019

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Background MRI is the imaging modality of choice for diagnosis and intervention assessment in neurological disease. Its full potential has not been realized due in part to challenges in harmonizing advanced techniques across multiple sites. Purpose To develop a method for the assessment of reliability and repeatability of advanced multisite‐multisession neuroimaging studies and specifically to assess the reliability of an advanced MRI protocol, including multiband fMRI and diffusion tensor MRI, in a multisite setting. Study Type Prospective. Population Twice repeated measurement of a single subject with stable relapsing‐remitting multiple sclerosis (MS) at seven institutions. Field Strength/Sequence A 3 T MRI protocol included higher spatial resolution anatomical scans, a variable flip‐angle longitudinal relaxation rate constant (R1 ≡ 1/T1) measurement, quantitative magnetization transfer imaging, diffusion tensor imaging, and a resting‐state fMRI (rsFMRI) series. Assessment Multiple methods of assessing intrasite repeatability and intersite reliability were evaluated for imaging metrics derived from each sequence. Statistical Tests Student's t‐test, Pearson's r, and intraclass correlation coefficient (ICC) (2,1) were employed to assess repeatability and reliability. Two new statistical metrics are introduced that frame reliability and repeatability in the respective units of the measurements themselves. Results Intrasite repeatability was excellent for quantitative R1, magnetization transfer ratio (MTR), and diffusion‐weighted imaging (DWI) based metrics (r > 0.95). rsFMRI metrics were less repeatable (r = 0.8). Intersite reliability was excellent for R1, MTR, and DWI (ICC >0.9), and moderate for rsFMRI metrics (ICC∼0.4). Data Conclusion From most reliable to least, using a new reliability metric introduced here, MTR > R1 > DWI > rsFMRI; for repeatability, MTR > DWI > R1 > rsFMRI. A graphical method for at‐a‐glance assessment of reliability and repeatability, effect sizes, and outlier identification in multisite‐multisession neuroimaging studies is introduced. Level of Evidence: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:878–888.

show abstract

“…DTI indices in the optic radiations have also been suggested to correlate with disability [156]. By contrast, DTI measures obtained by areas around lesions and NAWM have shown no correlation with clinical status [157].…”

Section: Multiple Sclerosismentioning

confidence: 98%

“…The proton magnetic resonance spectroscopy imaging (1H-MRSI) allows the evaluation of different cerebral metabolites in vivo [157]. A decreased ratio between Nacetylaspartate (NAA) and creatine, suggestive of axonal damage, has been reported in patients with radiologically isolated syndrome [158].…”

Section: Multiple Sclerosismentioning

confidence: 99%

Recent imaging advances in neurology

2015

View full text Add to dashboard Cite

Over the recent years, the application of neuroimaging techniques such as magnetic resonance imaging (MRI) and positron emission tomography (PET) has considerably advanced the understanding of complex neurological disorders. PET is a powerful molecular imaging tool, which investigates the distribution and binding of radiochemicals attached to biologically relevant molecules; as such, this technique is able to give information on biochemistry and metabolism of the brain in health and disease. MRI uses high intensity magnetic fields and radiofrequency pulses to provide structural and functional information on tissues and organs in intact or diseased individuals, including the evaluation of white matter integrity, grey matter thickness and brain perfusion. The aim of this article is to review the most recent advances in neuroimaging research in common neurological disorders such as movement disorders, dementia, epilepsy, traumatic brain injury and multiple sclerosis, and to evaluate their contribution in the diagnosis and management of patients.

show abstract

Diffusion Tensor Magnetic Resonance Imaging in Patients with Multiple Sclerosis and its Relationship with Disability

Abstract: SUMMARY -Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system. Diffusion tensor magnetic resonance imaging (DTI) can yield important informa

Cited by 11 publications

References 48 publications

Diffusion tensor imaging for assessment of normally appearing white matter of the brain and spinal cord in cases of multiple sclerosis: a multi-parametric correlation in view of patient’s clinical status

Diffusion tensor imaging for assessment of normally appearing white matter of the brain and spinal cord in cases of multiple sclerosis: a multi-parametric correlation in view of patient’s clinical status

Multisite reliability and repeatability of an advanced brain MRI protocol

Recent imaging advances in neurology

Contact Info

Product

Resources

About