Diffusion-Weighted Imaging for Head and Neck Squamous Cell Carcinoma: Quantifying Repeatability to Understand Early Treatment-Induced Change

Hoang, Jenny K.; Choudhury, Kingshuk Roy; Chang, Jim J.; Craciunescu, Oana; Yoo, David S.; Brizel, David M.

doi:10.2214/ajr.14.12838

Cited by 41 publications

(31 citation statements)

References 14 publications

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“…A similar observation was made in a recent study with 541 cases of nasopharyngeal carcinoma, showing that a high pretreatment ADC in the primary lesion predicted worse local relapse-free survival and disease-free survival [74]. Hoang et al [75] showed that the treatment-induced early change in ADC (32% ± 31%) of metastatic nodes is significantly different from the baseline variability (8% ± 7%) in the same nodes. These studies showed the feasibility of using DWI as a noninvasive imaging method to monitor treatment response.…”

Section: Treatment Response Monitoring and Predictionsupporting

confidence: 64%

Potential Role of PET/MRI for Imaging Metastatic Lymph Nodes in Head and Neck Cancer

Kim

Friedman

Patel

et al. 2016

American Journal of Roentgenology

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OBJECTIVE This article explores recent developments in PET and MRI, separately or combined, for assessing metastatic lymph nodes in patients with head and neck cancer. CONCLUSION The synergistic role of PET and MRI for imaging metastatic lymph nodes has not been fully explored. To facilitate the understanding of the areas that need further investigation, we discuss potential mechanisms and evidence reported so far, as well as future directions and challenges for continued development and clinical research.

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Section: Treatment Response Monitoring and Predictionsupporting

confidence: 64%

Potential Role of PET/MRI for Imaging Metastatic Lymph Nodes in Head and Neck Cancer

Kim

Friedman

Patel

et al. 2016

American Journal of Roentgenology

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“…Mean ADC values were compared between RT and diagnostic setups in the lesions based on the PET-derived ROIs. A variability or repeatability coefficient was calculated as the SD of ADC percentage change multiplied by 1.96 [38] .…”

Section: Methodsmentioning

confidence: 99%

Assessment of image quality of a radiotherapy-specific hardware solution for PET/MRI in head and neck cancer patients

Winter

Leibfarth

Schmidt

et al. 2018

Radiotherapy and Oncology

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Background and purposeFunctional PET/MRI has great potential to improve radiotherapy planning (RTP). However, data integration requires imaging with radiotherapy-specific patient positioning. Here, we investigated the feasibility and image quality of radiotherapy-customized PET/MRI in head-and-neck cancer (HNC) patients using a dedicated hardware setup.Material and methodsTen HNC patients were examined with simultaneous PET/MRI before treatment, with radiotherapy and diagnostic scan setup, respectively. We tested feasibility of radiotherapy-specific patient positioning and compared the image quality between both setups by pairwise image analysis of 18F-FDG-PET, T1/T2-weighted and diffusion-weighted MRI. For image quality assessment, similarity measures including average symmetric surface distance (ASSD) of PET and MR-based tumor contours, MR signal-to-noise ratio (SNR) and mean apparent diffusion coefficient (ADC) value were used.ResultsPET/MRI in radiotherapy position was feasible – all patients were successfully examined. ASSD (median/range) of PET and MR contours was 0.6 (0.4–1.2) and 0.9 (0.5–1.3) mm, respectively. For T2-weighted MRI, a reduced SNR of −26.2% (−39.0–−11.7) was observed with radiotherapy setup. No significant difference in mean ADC was found.ConclusionsSimultaneous PET/MRI in HNC patients using radiotherapy positioning aids is clinically feasible. Though SNR was reduced, the image quality obtained with a radiotherapy setup meets RTP requirements and the data can thus be used for personalized RTP.

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“…Diffusion-weighted imaging (DWI) has been applied to measure tumor changes to assess the therapy response [ 10 ][ 11 ]. Normally, the apparent diffusion coefficient (ADC) of water molecules within living tissues is derived from diffusion images with an assumption that the water molecular diffusion is a random process [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Intravoxel Incoherent Motion Diffusion Weighted MR Imaging for Monitoring the Instantly Therapeutic Efficacy of Radiofrequency Ablation in Rabbit VX2 Tumors without Evident Links between Conventional Perfusion Weighted Images

Guo

Zhang

et al. 2015

PLoS ONE

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ObjectiveTo investigate the intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) as a potential valuable marker to monitor the therapy responses of VX2 to radiofrequency ablation (RF Ablation).MethodsThe institutional animal care and use committee approved this study. In 10 VX2 tumor–bearing rabbits, IVIM-DWI examinations were performed with a 3.0T imaging unit by using 16 b values from 0 to 800 sec/mm2. The true diffusion coefficient (D), pseudodiffusion coefficient (D*) and perfusion fraction (f) of tumors were compared between before and instantly after RF Ablation treatment. The differences of D, D* and f and conventional perfusion parameters (from perfusion CT and dynamic enhanced magnetic resonance imaging, DCE-MRI) in the coagulation necrosis area, residual unablated area, untreated area, and normal control had been calculated by compared t- test. The correlation between f or D* with perfusion weighted CT including blood flow, BF (milliliter per 100 mL/min), blood volume, BV (milliliter per 100 mL/min), and capillary permeability–surface area, PMB (as a fraction) or from DCE-MRI: transfer constant (Ktrans), extra-vascular extra-cellular volume fraction (Ve) and reflux constant (Kep) values had been analyzed by region-of-interest (ROI) methods to calculate Pearson’s correlation coefficients.ResultsIn the ablated necrosis areas, f and D* significantly decreased and D significantly increased, compared with residual unblazed areas or untreated control groups and normal control groups (P < 0.001). The IVIM-DWI derived f parameters showed significant increases in the residual unablated tumor area. There was no significant correlations between f or D* and conventional perfusion parameters.ConclusionsThe IVIM-DW derived f, D and D* parameters have the potential to indicate therapy response immediately after RF Ablation treatment, while no significant correlations with classical tumor perfusion metrics were derived from DCE-MRI and perfusion-CT measurements.

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Diffusion-Weighted Imaging for Head and Neck Squamous Cell Carcinoma: Quantifying Repeatability to Understand Early Treatment-Induced Change

Abstract: Baseline ADC variability for HNSCC is less than intratreatment ADC change for nodal disease. Assessment of response should consider intrinsic baseline variability.

Cited by 41 publications

References 14 publications

Potential Role of PET/MRI for Imaging Metastatic Lymph Nodes in Head and Neck Cancer

Potential Role of PET/MRI for Imaging Metastatic Lymph Nodes in Head and Neck Cancer

Assessment of image quality of a radiotherapy-specific hardware solution for PET/MRI in head and neck cancer patients

Intravoxel Incoherent Motion Diffusion Weighted MR Imaging for Monitoring the Instantly Therapeutic Efficacy of Radiofrequency Ablation in Rabbit VX2 Tumors without Evident Links between Conventional Perfusion Weighted Images

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