Diffusion-weighted imaging in assessing renal pathology of chronic kidney disease: A preliminary clinical study

Li, Qinghai; Li, Jinning; Zhang, Lan; Chen, Ying; Zhang, Minming; Yan, Fuhua

doi:10.1016/j.ejrad.2014.01.024

Cited by 72 publications

(57 citation statements)

References 21 publications

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“…Moreover, IgA nephropathy is a typical form of CKD and also accounted for a large part of the samples in our study. The previous studies in CKD patients also applied this scoring system to the pathological assessment …”

Section: Methodsmentioning

confidence: 99%

Chronic kidney disease: Pathological and functional evaluation with intravoxel incoherent motion diffusion‐weighted imaging

Mao

Zhou

Zeng

et al. 2017

Magnetic Resonance Imaging

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Section: Methodsmentioning

confidence: 99%

Chronic kidney disease: Pathological and functional evaluation with intravoxel incoherent motion diffusion‐weighted imaging

Mao

Zhou

Zeng

et al. 2017

Magnetic Resonance Imaging

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“…Clinically, radiologists and nephrologists appreciate the utility of the DWI-MRI technique in assessing renal physiological or pathological changes. Previous studies have shown that the DWI technique is a sensitive method for detecting renal function in patients with chronic kidney disease [9], evaluating renal allografts function [10], assessing the severity of renal pathology, and guiding therapy for patients with CKD [11]. To the best of our knowledge, only two studies focused on the use of DWI-MRI in LN have been published.…”

Section: Introductionmentioning

confidence: 98%

Assessment of Renal Pathological Changes in Lupus Nephritis Using Diffusion Weighted Imaging: A Multiple Correspondence Analysis

Zhao

Yan

Jia

et al. 2018

Kidney Blood Press Res

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Background/Aims: Renal pathological changes affect the motion of water molecules, which can be detected using diffusion-weighted imaging (DWI). The current study was performed to explore the correlation between renal tissue pathological injuries and DWI iconographical parameters in lupus nephritis (LN). Methods: Twenty adult patients with LN and 11 healthy volunteers were recruited. Patients with LN received renal biopsies and renal DWI-MRI inspections. The renal biopsy tissues were characterized based on the ISN/RPS 2003 classification. The volunteers, who were of comparable gender and age, only underwent renal DWI-MRI inspection. Four DWI parameters, namely, apparent diffusion coefficient (ADC), pure diffusion coefficient (D_t), pseudo-diffusion coefficient (D_p), and perfusion fraction (f_p), were calculated using monoexponential and biexponential functions, respectively. Data from different renal areas and pathological pattern groups were compared. Multiple correspondence analysis (MCA) was performed to explore the correlation between each DWI index and multiple pathological features. Results: ADC, D_t, and f_p values were lower in the LN group compared to the controls (P < 0.001) regardless of the renal area in the cortex and medulla. D_p values were higher in the LN group (P = 0.004). A difference in mean DWI parameters was found between three LN subgroups and the healthy volunteers, with the exception of the D_p index in the renal cortex. MCA showed that serious proliferative pathological injuries and lower ADC and D_t values were located in the same quadrant. The MCA plots of D_p and f_p provided similar results. Higher D_p and f_p values were located in the MCA plot quadrant with more serious proliferative pathological changes. Conclusion: DWI is a noninvasive technique that may be used to detect renal pathophysiological changes. Renal cell proliferation and intestinal fibrosis may impact the movement of water in certain microenvironments. Enhanced perfusion may be a compensatory mechanism that is associated with renal pathological injuries.

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“…Goyal et al 7 observed a restricted-diffusion pattern in both renal inflammatory lesions and renal cell carcinomas. Li et al 9 reported a correlation between ADC values and pathology score in chronic kidney disease.…”

Section: Introductionmentioning

confidence: 98%

Apparent diffusion coefficient measurements of bilateral kidneys at 3 T MRI: Effects of age, gender, and laterality in healthy adults

et al. 2014

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Diffusion-weighted imaging in assessing renal pathology of chronic kidney disease: A preliminary clinical study

Cited by 72 publications

References 21 publications

Chronic kidney disease: Pathological and functional evaluation with intravoxel incoherent motion diffusion‐weighted imaging

Chronic kidney disease: Pathological and functional evaluation with intravoxel incoherent motion diffusion‐weighted imaging

Assessment of Renal Pathological Changes in Lupus Nephritis Using Diffusion Weighted Imaging: A Multiple Correspondence Analysis

Apparent diffusion coefficient measurements of bilateral kidneys at 3 T MRI: Effects of age, gender, and laterality in healthy adults

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