Diffusion weighted MRI and 18F-FDG PET/CT in non-small cell lung cancer (NSCLC): Does the apparent diffusion coefficient (ADC) correlate with tracer uptake (SUV)?

Regier, Marc; Derlin, Thorsten; Schwarz, Dorothee; Laqmani, Azien; Henes, Frank Oliver; Groth, Michael; Buhk, Jan Hendrik; Kooijman, Hendrik; Adam, Gerhard

doi:10.1016/j.ejrad.2011.11.050

Cited by 60 publications

(68 citation statements)

References 17 publications

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Section: Pet/ct Imagingmentioning

confidence: 99%

“…Before imaging, patients fasted for at least 6 h. All patients had blood glucose levels below 150 mg/dL at the time of 18 F-FDG injection. 18 F-FDG (300 ± 40 MBq) was intravenously injected 60 min before the scan. The contrast-enhanced CT scan was taken with the following parameters: caudocranial scan direction, field of view: skull base to upper thighs, 120 kV, automatic mA/s adjustment (Care Dose 4D™, preset: 210 mAs), 5 mm slice thickness, 5 mm increment, pitch 1.…”

Section: Pet/ct Imagingmentioning

confidence: 99%

“…For NSCLC a significant correlation between ADC values and SUV values derived from FDG-PET/CT has been reported [18]. Wholebody integrated PET/MRI scanners provide diagnostic image quality and comparably good lesion characterization and tumor staging in pulmonary masses as compared with PET/CT [16].…”

mentioning

confidence: 97%

“…Non-small cell lung cancer (NSCLC) accounts for approximately 80 % of all bronchogenic malignancies [1]. For a stage-adapted therapy and thus an individual therapeutic concept, 18 F-fluoro-desoxy-glucose-positron emission tomography/computed tomography (FDG-PET/ CT) is accepted as the diagnostic modality of choice, because of its high accuracy for the detection of the primary lesion and metastases in particular [2]. Furthermore, the maximum standard uptake value (SUV max ) of NSCLC assessed by FDG-PET/CT is established as an independent marker of tumor characteristics [3].…”

mentioning

confidence: 99%

“…In a pilot study with 10 patients, Schwenzer et al recently highlighted the potential of PET/MR for the assessment of pulmonary masses, showing a similar lesion characterization and tumor stage compared to PET/CT [16]. Regier and colleagues demonstrated a significant inverse correlation between the SUVmax determined by FDG-PET/CT and the ADC in NSCLC [18]. Recently, the use of ADC values derived from simultaneous DWI and PET acquisitions in a whole-body PET/ MRI scanner has been proven to be stable for clinical applications [19].…”

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confidence: 99%

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Correlation of the Apparent Diffusion Coefficient (ADC) with the Standardized Uptake Value (SUV) in Hybrid 18F-FDG PET/MRI in Non-Small Cell Lung Cancer (NSCLC) Lesions: Initial Results

Heusch¹,

Buchbender²,

Köhler

et al. 2013

Fortschr Röntgenstr

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Purpose: To compare the apparent diffusion coefficient (ADC) in non-small cell lung cancer lesions with standardized uptake values (SUV) derived from combined 18F-fluoro-deoxy-glucose-positron emission tomography/magnetic resonance imaging (FDG-PET/MRI) and those derived from FDG-PET/CT. Materials and Methods: In 18 consecutive patients with histologically proven NSCLC (17 men, 1 woman; mean age, 61???12 years), whole-body FDG-PET/MRI was performed after whole-body FDG-PET/CT. Regions of interest (ROI) encompassing the entire primary tumor were drawn into FDG-PET/CT and FDG-PET/MR images to determine the maximum and mean standardized uptake value (SUVmax; SUVmean) and into ADC parameter maps to assess mean ADC values. Pearson?s correlation coefficients were calculated to compare SUV and ADC values. Results: The SUVmax of NSCLC was 12.3???4.8 [mean ?SD], and the SUVmean was 7.2???2.8 as assessed by FDG-PET/MRI. The SUVmax and SUVmean derived from FDG-PET/CT and FDG-PET/MRI correlated well (R?=?0.93; p?

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Section: Pet/ct Imagingmentioning

confidence: 99%

Section: Pet/ct Imagingmentioning

confidence: 99%

mentioning

confidence: 97%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Correlation of the Apparent Diffusion Coefficient (ADC) with the Standardized Uptake Value (SUV) in Hybrid 18F-FDG PET/MRI in Non-Small Cell Lung Cancer (NSCLC) Lesions: Initial Results

Heusch¹,

Buchbender²,

Köhler

et al. 2013

Fortschr Röntgenstr

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Whole body MRI: Improved lesion detection and characterization with diffusion weighted techniques

Attariwala

Picker

2013

Magnetic Resonance Imaging

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Diffusion-weighted imaging (DWI) is an established functional imaging technique that interrogates the delicate balance of water movement at the cellular level. Technological advances enable this technique to be applied to whole-body MRI. Theory, b-value selection, common artifacts and target to background for optimized viewing will be reviewed for applications in the neck, chest, abdomen, and pelvis. Whole-body imaging with DWI allows novel applications of MRI to aid in evaluation of conditions such as multiple myeloma, lymphoma, and skeletal metastases, while the quantitative nature of this technique permits evaluation of response to therapy. Persisting signal at high b-values from restricted hypercellular tissue and viscous fluid also permits applications of DWI beyond oncologic imaging. DWI, when used in conjunction with routine imaging, can assist in detecting hemorrhagic degradation products, infection/abscess, and inflammation in colitis, while aiding with discrimination of free fluid and empyema, while limiting the need for intravenous contrast. DWI in conjunction with routine anatomic images provides a platform to improve lesion detection and characterization with findings rivaling other combined anatomic and functional imaging techniques, with the added benefit of no ionizing radiation.

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Whole‐body simultaneous positron emission tomography (PET)‐MR: Optimization and adaptation of MRI sequences

Fowler

McConathy

Narra

2013

Magnetic Resonance Imaging

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The purpose of this article is to introduce the underlying challenges associated with the incorporation of magnetic resonance imaging (MRI) into the new hybrid imaging modality simultaneous positron emission tomography (PET)/MR and their impact on attenuation correction, sequence optimization, and protocol development. Many adjustments to MR sequences are necessary for optimal whole-body and fused image results.

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Diffusion weighted MRI and 18F-FDG PET/CT in non-small cell lung cancer (NSCLC): Does the apparent diffusion coefficient (ADC) correlate with tracer uptake (SUV)?

Cited by 60 publications

References 17 publications

Correlation of the Apparent Diffusion Coefficient (ADC) with the Standardized Uptake Value (SUV) in Hybrid 18F-FDG PET/MRI in Non-Small Cell Lung Cancer (NSCLC) Lesions: Initial Results

Correlation of the Apparent Diffusion Coefficient (ADC) with the Standardized Uptake Value (SUV) in Hybrid 18F-FDG PET/MRI in Non-Small Cell Lung Cancer (NSCLC) Lesions: Initial Results

Whole body MRI: Improved lesion detection and characterization with diffusion weighted techniques

Whole‐body simultaneous positron emission tomography (PET)‐MR: Optimization and adaptation of MRI sequences

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