Diffusion-weighted MRI of exercise-induced acute renal failure (ALPE)

Ohta, Kazuhide; Yokoyama, Tadafumi; Shimizu, Masaki; Mizuno, Kazunori; Sakazume, Shinobu; Fujiki, Takuma; Saikawa, Yoshiro; Yachie, Akihiro

doi:10.1007/s00467-011-1869-y

Cited by 5 publications

(4 citation statements)

References 14 publications

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“…Previous studies of ALPE have noted the high sensitivity of T1-weighted imaging; for example, one case series noted localized signal hyperintensity in four of six patients ( 1 ), and another found signal hyperintensity in the kidneys of all three cases evaluated ( 3 ). A report of two pediatric ALPE patients showed clear wedge-shaped hyperintensity on DWI and slight signal hyperintensity on T2-weighted MRI ( 25 ), as seen in our case.…”

Section: Discussionsupporting

confidence: 77%

Acute Renal Failure with Severe Loin Pain and Patchy Renal Vasoconstriction in a Patient without Hypouricemia, Provoked by Epileptic Seizure

et al. 2017

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A 26-year-old Japanese man without hypouricemia and with 3 previous episodes of seizures concurrent with acute kidney injury (AKI) was admitted due to an epileptic seizure, lower back pain and AKI. His creatinine kinase levels were slightly elevated. Patchy renal ischemia on contrast-enhanced computed tomography and persistent residual contrast medium was observed, consistent with acute renal failure with severe loin pain and patchy renal ischemia after anaerobic exercise (ALPE). Diffusion-weighted imaging (DWI) demonstrated signal changes in the corresponding area. ALPE should be considered a cause of AKI following seizures. We recommend DWI as an alternative diagnostic modality.

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Section: Discussionsupporting

confidence: 77%

Acute Renal Failure with Severe Loin Pain and Patchy Renal Vasoconstriction in a Patient without Hypouricemia, Provoked by Epileptic Seizure

et al. 2017

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“…There are reports of similar findings [10, 28, 29], a report suggesting renal angina [10], and another indicating reversible renal vasoconstriction [30]. They support the active oxygen scavenging insufficiency/renal ischemia hypothesis.…”

Section: Discussionsupporting

confidence: 59%

Non-urate transporter 1, non-glucose transporter member 9-related renal hypouricemia and acute renal failure accompanied by hyperbilirubinemia after anaerobic exercise: a case report

et al. 2019

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BackgroundRenal hypouricemia (RHUC) is an inherited heterogenous disorder caused by faulty urate reabsorption transporters in the renal proximal tubular cells. Anaerobic exercise may induce acute kidney injury in individuals with RHUC that is not caused by exertional rhabdomyolysis; it is called acute renal failure with severe loin pain and patchy renal ischemia after anaerobic exercise (ALPE).RHUC is the most important risk factor for ALPE. However, the mechanism of onset of ALPE in patients with RHUC has not been elucidated. The currently known genes responsible for RHUC are SLC22A12 and SLC2A9.Case presentationA 37-year-old man presented with loin pain after exercising. Despite having a healthy constitution from birth, biochemical examination revealed hypouricemia, with a uric acid (UA) level of < 1 mg/dL consistently at every health check. We detected acute kidney injury, with a creatinine (Cr) level of 4.1 mg/dL, and elevated bilirubin; hence, the patient was hospitalized. Computed tomography revealed no renal calculi, but bilateral renal swelling was noted. Magnetic resonance imaging detected cuneiform lesions, indicating bilateral renal ischemia. Fractional excretion values of sodium and UA were 0.61 and 50.5%, respectively. Urinary microscopy showed lack of tubular injury. The patient’s older sister had hypouricemia. The patient was diagnosed with ALPE. Treatment with bed rest, fluid replacement, and nutrition therapy improved renal function and bilirubin levels, and the patient was discharged on day 5. Approximately 1 month after onset of ALPE, his Cr, UA, and TB levels were 0.98, 0.8, and 0.9 mg/dL, respectively. We suspected familial RHUC due to the hypouricemia and family history and performed genetic testing but did not find the typical genes responsible for RHUC. A full genetic analysis was opposed by the family.ConclusionsTo the best of our knowledge, this is the first report of ALPE with hyperbilirubinemia. Bilirubin levels may become elevated as a result of heme oxygenase-1 activation, occurring in exercise-induced acute kidney injury in patients with RHUC; this phenomenon suggests renal ischemia-reperfusion injury. A new causative gene coding for a urate transporter may exist, and its identification would be useful to clarify the urate transport mechanism.

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“…Plain [29] or Doppler sonography [30] and Tc-99m DTPA renography [31] can have a diagnostic role in PRV. Recently, the role of diffusion-weighted MRI in the diagnosis of ALPE has been reported, and it showed wedge-shaped signal hyperintensity [32] . Contrast-enhanced ultrasonography with Levovist was reported as a diagnostic tool and revealed wedge-shaped filling defects [33] , [34] .…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of acute renal failure with severe loin pain and patchy renal vasoconstriction

Lee

et al. 2012

Kidney Research and Clinical Practice

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BackgroundAcute renal failure (ARF) with severe loin pain and patchy renal vasoconstriction (PRV) is a syndrome presenting with sudden loin pain after anaerobic exercise. We aimed to investigate the clinical characteristics and the efficacy of diagnostic imaging studies of patients with this syndrome.MethodsWe retrospectively selected 17 patients with ARF accompanied by loin or abdominal pain who showed multiple patchy wedge-shaped delayed contrast enhancements on a computerized tomography scan. Information about the clinical characteristics, including the nature of pain and combined symptoms, suspected causes, such as exercise, drug or alcohol intake, and renal hypouricemia, and the results of laboratory and imaging tests were gathered.ResultsThe mean age of patients with episodes of ARF accompanied by loin pain was 23.0±6.5 (range 16–35) years old. Pain was mainly located in the loin (70.6%) or abdominal area (76.5%) and continued for approximately 3.5±4.0 days. Exercise was suspected as a primary cause of disease in 12 (70.6%) patients. Maximal serum creatinine was 5.42±3.16 (1.4–12.1) mg/dL 3.1±1.8 (1–7) days after the onset of pain. The peak level of serum uric acid was 9.41±2.91 (6.0–15.8) mg/dL. All of the patients recovered to near-normal renal function, and one patient showed hypouricemia after recovery.ConclusionARF with severe loin pain and PRV can present with loin or abdominal pain, even without a history of anaerobic exercise. Careful history taking and appropriate imaging studies are critical in the diagnosis and management of this syndrome.

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Diffusion-weighted MRI of exercise-induced acute renal failure (ALPE)

Cited by 5 publications

References 14 publications

Acute Renal Failure with Severe Loin Pain and Patchy Renal Vasoconstriction in a Patient without Hypouricemia, Provoked by Epileptic Seizure

Acute Renal Failure with Severe Loin Pain and Patchy Renal Vasoconstriction in a Patient without Hypouricemia, Provoked by Epileptic Seizure

Non-urate transporter 1, non-glucose transporter member 9-related renal hypouricemia and acute renal failure accompanied by hyperbilirubinemia after anaerobic exercise: a case report

Clinical characteristics of acute renal failure with severe loin pain and patchy renal vasoconstriction

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