Diffusions of β-cyclodextrins in mucus studied by 19F diffusion NMR

Nguyen, Kim T.; Mathias, Errol V.; Porter, Edith; Ba, Yi

doi:10.1007/s10847-016-0666-4

Cited by 4 publications

(8 citation statements)

References 43 publications

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“…Another commonly used method is NMR and most recently the use of F‐19 entrapped in different cyclodextrins was successfully used to probe the pore size of submaxillary and nasal mucins . This method shows great promise for the future.…”

Section: Methods For Characterizing Mucus Permeabilitymentioning

confidence: 99%

“…At the molecular level, the diffusion chamber has been used to determine the diffusion of molecules through mucus, [189] but this has rather been superseded by other more relevant methods that can be applied directly on live animals in the gut [190] or nasal cavity. [191] Another commonly used method is NMR [192][193][194] and most recently the use of F-19 entrapped in different cyclodextrins was successfully used to probe the pore size of submaxillary and nasal mucins. [193] This method shows great promise for the future.…”

Section: Methods For Characterizing Mucus Permeabilitymentioning

confidence: 99%

“…[191] Another commonly used method is NMR [192][193][194] and most recently the use of F-19 entrapped in different cyclodextrins was successfully used to probe the pore size of submaxillary and nasal mucins. [193] This method shows great promise for the future. There has been a significant amount of research on the use of particles as delivery systems through mucus and as a consequence a wide range of methods have been used many of which have been described an a recent review by Griessinger et al [195] The quartz crystal microbalance with dissipation (QCM-D) has been used to assess the combined properties between mucoadhesion and permeability of thiolated chitosans and their complexes with a layer of native porcine gastric mucin.…”

Section: Methods For Characterizing Mucus Permeabilitymentioning

confidence: 99%

See 2 more Smart Citations

Innovative Methods and Applications in Mucoadhesion Research

Mackie

Goycoolea

Menchicchi

et al. 2017

Macromolecular Bioscience

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The present review is aimed at elucidating relatively new aspects of mucoadhesion/mucus interaction and related phenomena that emerged from a Mucoadhesion workshop held in Munster on 2-3 September 2015 as a satellite event of the ICCC 13th-EUCHIS 12th. After a brief outline of the new issues, the focus is on mucus description, purification, and mucus/mucin characterization, all steps that are pivotal to the understanding of mucus related phenomena and the choice of the correct mucosal model for in vitro and ex vivo experiments, alternative bio/mucomimetic materials are also presented. Then a selection of preparative techniques and testing methods are described (at molecular as well as micro and macroscale) that may support the pharmaceutical development of mucus interactive systems and assist formulators in the scale-up and industrialization steps. Recent applications of mucoadhesive systems (including medical devices) intended for different routes of administration (oral, gastrointestinal, vaginal, nasal, ocular, and intravesical) and for the treatment of difficult to treat pathologies or the alleviation of symptoms are described.

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Section: Methods For Characterizing Mucus Permeabilitymentioning

confidence: 99%

Section: Methods For Characterizing Mucus Permeabilitymentioning

confidence: 99%

Section: Methods For Characterizing Mucus Permeabilitymentioning

confidence: 99%

See 1 more Smart Citation

Innovative Methods and Applications in Mucoadhesion Research

Mackie

Goycoolea

Menchicchi

et al. 2017

Macromolecular Bioscience

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“…Interestingly, whereas the gel permeability towards neutral and anionic dextrans remains virtually unchanged until a mucin content of 2% (w/v), we observe a marked reduction in the translocation efficiency of those two off‐target molecules once a mucin concentration of 4% (w/v) is reached. Probably, as mucins are very large macromolecules, this effect is due to a reduced mesh size of this hybrid network that limits the diffusive spreading of all dextrans at this high mucin concentration 34 …”

Section: Resultsmentioning

confidence: 99%

Agarose‐based hydrogels with tunable, charge‐selective permeability properties

Zhao

Marczynski

Henkel

et al. 2023

J of Applied Polymer Sci

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Physiologically, a hallmark of biological hydrogels is their ability to selectively trap diffusing molecules and particles. And indeed, there is now increasing interest in using selective hydrogel barriers for applications in biomedicine and medical engineering. However, when employing synthetic polymers to create hydrogels with selective permeabilities, controlling the type and strength of the ensuing filtration process is difficult. Here, we generate hybrid gels with adjustable selectivity profiles by mixing a series of (bio‐)macromolecules with agarose. Depending on the type and concentration of the incorporated macromolecules, those hybrid gels achieve a selective retardation of the diffusive translocation of either positively or negatively charged dextrans at both, acidic and neutral pH. Furthermore, we demonstrate three strategies that provide hydrogels with sequestered patches of both, cationic and anionic binding sites, thus creating symmetric charge (i.e., electrostatic bandpass) filters which still allow neutral molecules to pass. Moreover, such agarose matrices offer a high level of versatility as their permeability profiles can be tailored at will by integrating macromolecules with desired physico‐chemical properties. Thus, those agarose‐based hybrid gels may serve as a powerful platform to engineer adjustable and versatile materials for a broad range of future applications in the field of biomedical engineering.

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“…Most of the experimental work reported in the literature explores the nature of the interactions between a bio-gel and a particle through various particle diffusion tracking techniques which use in vitro, in vivo, and ex vivo models[ 2 , 19 , 20 , 24 , 35 , 45 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 ]. These experiments do not account for the influence of external physiological forces and thus cannot fully capture the true response of biological gels in their native dynamic environment.…”

Section: Forced Particle Penetrationmentioning

confidence: 99%

A Microscopically Motivated Model for Particle Penetration into Swollen Biological Networks

2020

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Biological gels (bio-gels) are hydrated polymer networks that serve diverse biological functions, which often lead to intentional or unintentional exposure to particulate matter. In this work, we derive a microscopically motivated framework that enables the investigation of penetration mechanisms into bio-gels. We distinguish between two types of mechanisms: spontaneous (unforced) penetration and forced penetration. Using experimental data available in the literature, we exploit the proposed model to characterize and compare between the microstructures of respiratory, intestinal, and cervicovaginal mucus and two types of biofilms. Next, we investigate the forced penetration process of spherical and ellipsoidal particles into a locally quadrilateral network. The proposed framework can be used to improve and complement the analysis of experimental findings in vitro, ex vivo, and in vivo. Additionally, the insights from this work pave the way towards enhanced designs of nano-medicines and allow the assessment of risk factors related to the nano-pollutants exposure.

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Diffusions of β-cyclodextrins in mucus studied by 19F diffusion NMR

Cited by 4 publications

References 43 publications

Innovative Methods and Applications in Mucoadhesion Research

Innovative Methods and Applications in Mucoadhesion Research

Agarose‐based hydrogels with tunable, charge‐selective permeability properties

A Microscopically Motivated Model for Particle Penetration into Swollen Biological Networks

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