Diffusivity of intraorbital lymphoma vs. inflammation: comparison of single shot turbo spin echo and multishot echo planar imaging techniques

Hiwatashi, Akio; Togao, Osamu; Yamashita, Koji; Kikuchi, Kazufumi; Kamei, Ryotaro; Yoshikawa, Hiroshi; Takemura, Akihiro; Honda, Hiroshi

doi:10.1007/s00330-017-4995-5

Cited by 22 publications

(14 citation statements)

References 26 publications

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“…1,4 However, severe image distortion, observed at the interfaces of different susceptibilities, and chemical shift artifacts often cause image quality degeneration and inaccurate ADC measurements. 1,4 In overcoming this issue, a post-processing software could be used to correct misregistration due to eddy-current-induced distortion for specific analyses in diffusion-tensor imaging but is not used for ADC measurement in daily practice. The multi-shot EPI sequence was demonstrated to reduce image distortion artifacts, but the strong susceptibility effect still caused image distortion, especially in non-brain imaging.…”

Section: Discussionmentioning

confidence: 99%

“…TSE-DWI uses a 180° radiofrequency refocusing pulse for each measured echo, which explains the strong reduction of the susceptibility artifacts. 1,4,5,[7][8][9] One of the problems with TSE-DWI has been motion artifacts resulting from the slower data acquisition. Nevertheless, combined use of the single-shot technique and parallel imaging technique, which is generally used for breath-hold ultrafast T 2 -weighted imaging, was recently enabled for this TSE-DWI sequence.…”

Section: Discussionmentioning

confidence: 99%

“…Diffusion-weighted imaging (DWI), a non-contrast imaging technique, is widely used to evaluate both intracranial and extracranial tumors. 1 Many studies have reported that apparent diffusion coefficient (ADC) values are useful in distinguishing between malignant and benign musculoskeletal tumors. 2 A coronal DWI scan can cover a larger area of the hand than axial DWI and might be useful for evaluating multiple lesions, arthritis, or tendinitis.…”

Section: Introductionmentioning

confidence: 99%

“…3 However, on coronal DWI with echo-planar imaging (EPI), especially when evaluating a hand or foot, severe image distortions due to susceptibility artifacts and chemical shift artifacts degrade lesion conspicuity. 1,4 Single-shot turbo spin-echo (TSE) DWI reduces these image distortion and chemical shift artifacts, but severe image noise and blurring degrade the image quality and ADC measurements. 4 Recently, parallel imaging technique and higher signal-to-noise ratio (SNR) at 3T improved these issues with single-shot TSE-DWI.…”

Section: Introductionmentioning

confidence: 99%

“…4 Recently, parallel imaging technique and higher signal-to-noise ratio (SNR) at 3T improved these issues with single-shot TSE-DWI. 1,4 The utility of TSE-DWI has been reported in evaluations of middle ear cholesteatoma, orbital and neck lesions, TECHNICAL NOTE study was assessment of the image quality and artifacts with 4-point scales. The secondary endpoint was comparison of ADC, as described in detail below.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Thin-slice Coronal Single-shot Turbo Spin-echo Diffusion-weighted Imaging of the Hand: A Comparison with Conventional Echo-planar Diffusion-weighted Imaging

Ogawa

Nakagawa

Arai

et al. 2020

MRMS

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We prospectively evaluated thin-slice coronal turbo spin-echo (TSE) diffusion-weighted imaging (DWI) covering a larger area with the recently-developed techniques on a 3T MRI scanner, compared with echoplanar imaging (EPI)-DWI in patients undergoing routine hand MRI. Visual score assessment and apparent diffusion coefficient (ADC) measurement were performed for patients with suspected hand tumors. TSE-DWI was superior to EPI-DWI, with less image distortion. The visual score and ADC comparison assessments proved that the image noise of TSE-DWI was acceptable.breast and lung cancers, and spinal cord infarction. 1,5-10 To the best of our knowledge, however, there have been no TSE-DWI studies evaluating musculoskeletal lesions of the hand or foot. In addition, only one previous case report evaluated middle ear cholesteatoma using 2-mm-thick single-shot TSE-DWI, but ADC measurement was not performed and the acquisition time was not presented. 6 TSE-DWI using the recently-developed parallel imaging and single-shot technique on 3T MRI might yield a superior image quality and is already used clinically. However, the image quality of thin-slice TSE-DWI for the assessment of small musculoskeletal lesions has not yet been clarified. Thus, the purpose of this study was to prospectively examine whether the 2-mm-thick coronal TSE-DWI covering a larger area and small lesions could substitute for conventional EPI-DWI in patients undergoing routine hand MRI on a 3T scanner. Materials and Methods Study designThis prospective study was performed in accordance with the ethical standards of our Institutional Review Board. Written informed consent was obtained from the patients and their privacy was completely protected. Eligibility criteria for entry were: (1) adult patients suspected of having or being followed for a musculoskeletal tumor of the hand or finger, (2) patient agreement to cooperate, and (3) examination on a Philips 3T MRI scanner (Ingenia; Philips Medical Systems, Eindhoven, The Netherlands). The exclusion criteria were:(1) contraindications to MR (incompatible metal implants or pacemakers), and (2) motion artifacts and artifacts from unsuppressed fat on the images. The primary endpoint of the

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of Thin-slice Coronal Single-shot Turbo Spin-echo Diffusion-weighted Imaging of the Hand: A Comparison with Conventional Echo-planar Diffusion-weighted Imaging

Ogawa

Nakagawa

Arai

et al. 2020

MRMS

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A pan‐inflammatory microRNA‐cluster is associated with orbital non‐Hodgkin lymphoma and idiopathic orbital inflammation

et al. 2019

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Non‐Hodgkin orbital lymphoma (NHOL) and idiopathic orbital inflammation (IOI) are common orbital conditions with largely unknown pathophysiology that can be difficult to diagnose. In this study we aim to identify serum miRNAs associated with NHOL and IOI. We performed OpenArray® miRNA profiling in 33 patients and controls. Differentially expressed miRNAs were technically validated across technology platforms and replicated in an additional cohort of 32 patients and controls. We identified and independently validated a serum miRNA profile of NHOL that was remarkably similar to IOI and characterized by an increased expression of a cluster of eight miRNAs. Pathway enrichment analysis indicated that the miRNA‐cluster is associated with immune‐mediated pathways, which we supported by demonstrating the elevated expression of this cluster in serum of patients with other inflammatory conditions. The cluster contained miR‐148a, a key driver of B‐cell tolerance, and miR‐365 that correlated with serum IgG and IgM concentrations. In addition, miR‐29a and miR‐223 were associated with blood lymphocyte and neutrophil populations, respectively. NHOL and IOI are characterized by an abnormal serum miRNA‐cluster associated with immune pathway activation and linked to B cell and neutrophil dysfunction.

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Imaging Techniques

Chon¹,

Potter²,

Singh³

2019

Clinical Ophthalmic Oncology

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Diffusivity of intraorbital lymphoma vs. inflammation: comparison of single shot turbo spin echo and multishot echo planar imaging techniques

Abstract: • ADC of lymphoma was significantly lower than that of inflammation. • ADC derived from TSE DWI showed the best diagnostic performance. • This study was conducted by a 3-T MR scanner.

Cited by 22 publications

References 26 publications

Evaluation of Thin-slice Coronal Single-shot Turbo Spin-echo Diffusion-weighted Imaging of the Hand: A Comparison with Conventional Echo-planar Diffusion-weighted Imaging

Evaluation of Thin-slice Coronal Single-shot Turbo Spin-echo Diffusion-weighted Imaging of the Hand: A Comparison with Conventional Echo-planar Diffusion-weighted Imaging

A pan‐inflammatory microRNA‐cluster is associated with orbital non‐Hodgkin lymphoma and idiopathic orbital inflammation

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