2020
DOI: 10.1089/omi.2019.0220
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Digging Deeper into Precision/Personalized Medicine: Cracking the Sugar Code, the Third Alphabet of Life, and Sociomateriality of the Cell

Abstract: Precision/personalized medicine is a hot topic in health care. Often presented with the motto ''the right drug, for the right patient, at the right dose, and the right time,'' precision medicine is a theory for rational therapeutics as well as practice to individualize health interventions (e.g., drugs, food, vaccines, medical devices, and exercise programs) using biomarkers. Yet, an alien visitor to planet Earth reading the contemporary textbooks on diagnostics might think precision medicine requires only two… Show more

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Cited by 25 publications
(6 citation statements)
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References 118 publications
(122 reference statements)
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“…Genetic and other factors influence glycosylation and, in turn, whether glycoproteins trigger anti-or pro-inflammatory responses [40]. This is associated with various diseases such as biological aging, metabolic syndrome, and coronavirus disease 2019 (COVID-19) [41][42][43][44]. Immunoglobulin G fragment crystallizable (IgG Fc) glycosylation has potential as a biomarker for T2DM [40], and the integration of glycomics with other biomarkers may offer further hope for future T2DM PPPM.…”
Section: Discussionmentioning
confidence: 99%
“…Genetic and other factors influence glycosylation and, in turn, whether glycoproteins trigger anti-or pro-inflammatory responses [40]. This is associated with various diseases such as biological aging, metabolic syndrome, and coronavirus disease 2019 (COVID-19) [41][42][43][44]. Immunoglobulin G fragment crystallizable (IgG Fc) glycosylation has potential as a biomarker for T2DM [40], and the integration of glycomics with other biomarkers may offer further hope for future T2DM PPPM.…”
Section: Discussionmentioning
confidence: 99%
“…2021 ). Finally, while pharmacogenomics is already an established field with multiple clinical applications, pharmacoglycomics is still understudied and its relevance is starting to be acknowledged ( Özdemir et al. 2020 ).…”
Section: Perspectives For the Wider Application Of Ht Glycomicsmentioning
confidence: 99%
“…Cancer studies are performed mostly based on alterations in genome, transcriptome, proteome, and metabolome levels, with a relatively small number of studies in alterations in glycan compositions and/or structures and glycoproteins [128]. However, the glycan studies have been increasing day by day to identify potential glycan alterations and glycoprotein biomarkers for cancer owing to the developments in glycans profiling [129].…”
Section: Glycomic Signatures Of Pancreatic Cancermentioning
confidence: 99%