DigiLoCS: A Leap Forward in Predictive Organ-on-Chip Simulations
Manoja Rajalakshmi Aravindakshan,
Chittaranjan Mandal,
Alex Pothen
et al.
Abstract:Digital twins, driven by data and mathematical modelling, have emerged as powerful tools for simulating complex biological systems. In this work, we focus on modelling the clearance on a liver-on-chip as a digital twin that closely mimics the clearance functionality of the human liver. Our approach involves the creation of a compartmental physiological model of the liver using ordinary differential equations (ODEs) to estimate pharmacokinetic (PK) parameters related to on-chip liver clearance. The objectives o… Show more
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