Digital approaches in electronic biochips

Abstract

Electronic biochips are defined by the merge of integrated electronics, containing diverse sensors, with reaction solution and sample hold in reaction chamber(s). Based on their overall structure, electronic biochips can work in either well-confined or in area-confined configurations. Extreme parceling of the sample (digital approach), coupled with electronic biochips, can radically enhance the throughput performance of the assay, especially in an area-defined configuration. This takes advantage of the increased sensitivity that follows device miniaturization, as illustrated in our experiments on Silicon Nano Ribbons.