Digital Evaluation of Orbital Cyst Associated with Microphthalmos: Characteristics and Their Relationship with Orbital Volume

Abstract

PurposeTo study the characteristics of orbital cyst associated with microphthalmos in a group of Chinese patients, and to analyze the relationship between orbital cyst and orbital volume.DesignCross-sectional comparative study.Participants120 patients who were diagnosed as unilateral clinical blind microphthalmos, in which 20 patients had orbital cyst in the affected eye.MethodParticipants had computed tomography (CT) scan. CT images were analyzed with a computer-aided software.Main Outcome MeasuresVolume and position of orbital cyst, microphthalmic to contralateral ratio (MCR) of orbital volume, height and depth and orbital rim displacement.Results38.1% of the cysts located anterior to or at the equator of the globe, 75% of which located infratemporally and all of which were outside the muscle cone. Most (84.6%) of the posterior cysts were inside the muscle cone. The anterior cysts were larger than the posterior cysts (p = 0.005). MCR of orbital volume (p<0.001), height (p = 0.004) and width (p = 0.043) were significantly higher in patients with orbital cyst than controls. For patients with orbital cyst, larger cyst-plus-globe volume of the affected eye was associated with higher MCR of orbital volume (r = 0.630, p = 0.003). Patients with large cyst-plus-globe volume had higher MCR of orbital volume (p = 0.002), height (p = 0.014), width (p = 0.005) and depth (p = 0.002) and less displacement in inferior (p = 0.004) orbital rim, compared with patients with small cyst-plus-globe volume, but the differences between patients with small cyst-plus-globe volume and patients without cyst were not significant.ConclusionsMicrophthalmic eyes with large cyst-plus-globe volume showed better similarity with the contralateral eyes, comparing with microphthalmic eyes without orbital cyst or with small cyst-plus-globe volume. It suggested that the existence of orbital cysts (especially large cysts) in microphthalmic eyes might play a positive role in the orbital development.

Intraorbital Colobomatous Cyst with Microphthalmia in a Child Presented with Orbital Mass

“…Microphthalmia with orbital cyst is very rare, and there is no agreed-upon rate of how often it happens [1]. Congenital microphthalmia with intraorbital cyst happens when the embryonic fissure doesn't close properly and the inner layer of the optic cup grows too much [4]. An extremely rare neuroectodermallined cyst, the colobomatous cyst was first described by Thomas Bartholin in 1673.…”

Cystic Lesions of the Orbit

“…In both of these conditions, the eye is usually severely malformed and nonfunctional, thus the primary goal of management is ensuring proper development of the orbit 5,47,52 . It is crucial to ascertain the level of visual function, if any, as attempts to preserve vision will guide the approach to cosmetic rehabilitation 5,46 .…”

Congenital Microphthalmia with Intraorbital Cyst: A Rare Case Report

“…Congenital microphthalmia with intraorbital cyst is a rare condition occurring due to defective closure of the embryonic ssure as well as over-growth of the inner layer of the optic cup [1]. e ssures begin to close at about 11 mm stage and is completed by 18 mm stage.…”

“…e prevalence rate of microphthalmia is found to be 1.4-3.5 per 10,000 births [5]. Microphthalmia with orbital cyst is considered to be extremely rare with no agreed prevalence rate [1].…”