Unmanned aerial vehicles (UAVs) are adaptable and rapid mobile boards that can be applied to several purposes, especially in smart cities. These involve traffic observation, environmental monitoring, and public safety. The need to realize effective drone forensic processes has mainly been reinforced by drone-based evidence. Drone-based evidence collection and preservation entails accumulating and collecting digital evidence from the drone of the victim for subsequent analysis and presentation. Digital evidence must, however, be collected and analyzed in a forensically sound manner using the appropriate collection and analysis methodologies and tools to preserve the integrity of the evidence. For this purpose, various collection and analysis models have been proposed for drone forensics based on the existing literature; several models are inclined towards specific scenarios and drone systems. As a result, the literature lacks a suitable and standardized drone-based collection and analysis model devoid of commonalities, which can solve future problems that may arise in the drone forensics field. Therefore, this paper has three contributions: (a) studies the machine learning existing in the literature in the context of handling drone data to discover criminal actions, (b) highlights the existing forensic models proposed for drone forensics, and (c) proposes a novel comprehensive collection and analysis forensic model (CCAFM) applicable to the drone forensics field using the design science research approach. The proposed CCAFM consists of three main processes: (1) acquisition and preservation, (2) reconstruction and analysis, and (3) post-investigation process. CCAFM contextually leverages the initially proposed models herein incorporated in this study. CCAFM allows digital forensic investigators to collect, protect, rebuild, and examine volatile and nonvolatile items from the suspected drone based on scientific forensic techniques. Therefore, it enables sharing of knowledge on drone forensic investigation among practitioners working in the forensics domain.