The present digital era has posed changes in the way businesses operate. This tied organizations to rethink their strategies to stay competitive. The chapter aims to explore the various strategic approaches that businesses in India are adopting for the transformation of their operations and to thrive amidst digital disruption. The chapter employs a multi-method approach as methodology which combines qualitative and quantitative research methods (however no statistical tools and primary data has been collected for the analysis and interpretation or for drawing conclusions). This chapter provides analysis of strategic approaches during e-business transformation with special reference to the Indian business context. The target audience for this chapter are business leaders, strategists, and decision-makers.