Digital printing of selective and reversible ion optodes on fabrics: toward smart clothes for epidermal chemical sensing

Brady, Brock; Wang, Renjie; Cheong, Rosemary; Wang, Xuewei

doi:10.1039/d1an01349a

Cited by 8 publications

(4 citation statements)

References 19 publications

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“…We did not find any reports on testing the acidity of silicone rubber matrices. Therefore, we designed a pH test method based on chromoionophore I, a hydrophobic Nile blue derivative widely used as a pH indicator in colorimetric and fluorescent optodes for pH and ions. , This dye is blue in its protonated form and purple in its deprotonated form. When dissolved in dioctyl sebacate, a plasticizer with a similar dielectric constant to silicone rubber (3–4 for both), chromoionophore I can only be fully protonated by an aqueous solution at a pH below 2 (Figure S5).…”

Section: Resultsmentioning

confidence: 99%

“…Among various ways to interface sensors with the human body, the functionalization of implantables or wearables already used for other purposes with sensors is particularly interesting. For example, optical chemical sensors have been created on garments to monitor sweat content . Synthetic biology sensors have been embedded into face masks to detect pathogens such as coronavirus in breath aerosols .…”

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confidence: 99%

“…For example, optical chemical sensors have been created on garments to monitor sweat content. 12 Synthetic biology sensors have been embedded into face masks to detect pathogens such as coronavirus in breath aerosols. 13 The fabrication of thin-film electrochemical glucose sensors onto insulin infusion cannulas required for insulin infusion obviates the need for insertion of two devices.…”

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confidence: 99%

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S-Nitrosothiol-Impregnated Silicone Catheter for Colorimetric Sensing of Indole and E. coli: Toward On-Body Detection of Urinary Tract Infections

Brady

Farooque

et al. 2022

ACS Sens.

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Although there are many techniques to detect pathogenic bacteria, most of them are only suited for in vitro diagnostics. We report a urinary catheter-based colorimetric sensor for potential on-body detection of E. coli, the most prevalent bacterial species in urinary tract infections associated with the use of urinary catheters. In urine, indole is secreted by E. coli and reacts with a nitrosating agent incorporated in a silicone catheter. A red dimeric product, indoxyl red, is generated within silicone rubber to allow for color-based indole sensing with high sensitivity, linearity, and specificity. This reaction is initiated by the nitrosation reaction of indole at its C-3 position via reagents like sodium nitrite or Snitroso-N-acetyl-penicillamine under aerobic conditions. The generated 3-nitrosoindole undergoes tautomerization, dimerization, and deoximation to form indoxyl red with high absorbance at 537 nm. In contrast to other indole sensors, the presented method can be applied in real catheters to detect indole and E. coli in biofluids such as urine. The is because (1) S-nitroso-N-acetyl-penicillamine, the nitrosating agent, can be impregnated into silicone elastomers, (2) indole from urine is extracted into silicone due to its hydrophobicity, and (3) the high acidity and oxygen solubility of silicone facilitates the sensing reaction within the silicone matrix. This silicone-based colorimetric sensor clearly differentiates E. coli below and above 10 5 CFU/mL, which is the threshold concentration of bacteriuria. We expect that early diagnosis of urinary tract infections using the naked eye is possible by functionalizing an exposed section of urinary catheters with the proposed molecular probe.

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Section: Resultsmentioning

confidence: 99%

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S-Nitrosothiol-Impregnated Silicone Catheter for Colorimetric Sensing of Indole and E. coli: Toward On-Body Detection of Urinary Tract Infections

Brady

Farooque

et al. 2022

ACS Sens.

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“…For example, cortisol in sweat can be measured by zinc oxide nanosheets, which combine with cortisol antibodies and are very sensitive (they can detect concentrations ranging from 1 to 200 ng/mL in sweat). Cortisol can reflect psychological or physiological stress [ 163 , 164 , 165 ]. Muscle activity has been predicted by K+ [ 153 ] and lactate concentrations in sweat.…”

Section: Sweat Detectionmentioning

confidence: 99%

Emerging Wearable Biosensor Technologies for Stress Monitoring and Their Real-World Applications

Ching

Wang

et al. 2022

Biosensors

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Wearable devices are being developed faster and applied more widely. Wearables have been used to monitor movement-related physiological indices, including heartbeat, movement, and other exercise metrics, for health purposes. People are also paying more attention to mental health issues, such as stress management. Wearable devices can be used to monitor emotional status and provide preliminary diagnoses and guided training functions. The nervous system responds to stress, which directly affects eye movements and sweat secretion. Therefore, the changes in brain potential, eye potential, and cortisol content in sweat could be used to interpret emotional changes, fatigue levels, and physiological and psychological stress. To better assess users, stress-sensing devices can be integrated with applications to improve cognitive function, attention, sports performance, learning ability, and stress release. These application-related wearables can be used in medical diagnosis and treatment, such as for attention-deficit hyperactivity disorder (ADHD), traumatic stress syndrome, and insomnia, thus facilitating precision medicine. However, many factors contribute to data errors and incorrect assessments, including the various wearable devices, sensor types, data reception methods, data processing accuracy and algorithms, application reliability and validity, and actual user actions. Therefore, in the future, medical platforms for wearable devices and applications should be developed, and product implementations should be evaluated clinically to confirm product accuracy and perform reliable research.

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Fully inkjet-printed paper-based Pb2+ optodes for water analysis without interference from the chloramine disinfectant

et al. 2022

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Digital printing of selective and reversible ion optodes on fabrics: toward smart clothes for epidermal chemical sensing

Abstract: While wearable chemical sensors often rely on electrochemical techniques, optical chemical sensors coupled with a smartphone or a miniaturized camera represent an attractive avenue to monitor sweat compositions. In this...

Cited by 8 publications

References 19 publications

S-Nitrosothiol-Impregnated Silicone Catheter for Colorimetric Sensing of Indole and E. coli: Toward On-Body Detection of Urinary Tract Infections

S-Nitrosothiol-Impregnated Silicone Catheter for Colorimetric Sensing of Indole and E. coli: Toward On-Body Detection of Urinary Tract Infections

Emerging Wearable Biosensor Technologies for Stress Monitoring and Their Real-World Applications

Fully inkjet-printed paper-based Pb2+ optodes for water analysis without interference from the chloramine disinfectant

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