Digital tomosynthesis mammography using a parallel maximum-likelihood reconstruction method

Wu, Tao; Zhang, Juemin; Moore, Richard H.; Rafferty, Elizabeth A.; Kopans, Daniel B.; Meleis, Waleed; Kaeli, David

doi:10.1117/12.534446

Cited by 43 publications

(38 citation statements)

References 10 publications

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“…Processing of the DOT and DBT measurements involved the reconstruction of the 3D DBT images ( 8 ), spatial registration between the DBT images and the optical probes, raw optical data calibration, and 3D breast mesh generation from the DBT images (23). More details are included in the study by Fang et al ( 22 ).…”

Section: Data Preprocessing and Image Reconstructionmentioning

confidence: 99%

“…The well-established image interpretation, general availability, and good image resolution render conventional mammography the obvious choice for radiologists for breast screening. Newer developments in x-ray breast imaging techniques, such as digital mammography ( 4,5 ) and three-dimensional (3D) digital breast tomosynthesis (DBT) (6)(7)(8)(9), are becoming mature methods. However, the high false-positive rate and the marginal contrast between tumor and dense breast tissue remain major challenges ( 10 ).…”

Section: Imaging Instrumentationmentioning

confidence: 99%

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Combined Optical and X-ray Tomosynthesis Breast Imaging

Fang¹,

Selb²,

Carp³

et al. 2011

Radiology

196

176

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Purpose:To explore the optical and physiologic properties of normal and lesion-bearing breasts by using a combined optical and digital breast tomosynthesis (DBT) imaging system. Materials and Methods:Institutional review board approval and patient informed consent were obtained for this HIPAA-compliant study. Combined optical and tomosynthesis imaging analysis was performed in 189 breasts from 125 subjects (mean age, 56 years 6 13 [standard deviation]), including 138 breasts with negative fi ndings and 51 breasts with lesions. Threedimensional (3D) maps of total hemoglobin concentration (Hb T ), oxygen saturation (S O 2 ), and tissue reduced scattering coeffi cients were interpreted by using the coregistered DBT images. Paired and unpaired t tests were performed between various tissue types to identify signifi cant differences. Results:The estimated average bulk Hb T from 138 normal breasts was 19.2 m mol/L. The corresponding mean SO 2 was 0.73, within the range of values in the literature. A linear correlation ( R = 0.57, P , .0001) was found between Hb T and the fi broglandular volume fraction derived from the 3D DBT scans. Optical reconstructions of normal breasts revealed structures corresponding to chest-wall muscle, fi broglandular, and adipose tissues in the Hb T , SO 2 , and scattering images. In 26 malignant tumors of 0.6-2.5 cm in size, Hb T was signifi cantly greater than that in the fibroglandular tissue of the same breast ( P = .0062). Solid benign lesions ( n = 17) and cysts ( n = 8) had signifi cantly lower Hb T contrast than did the malignant lesions ( P = .025 and P = .0033, respectively). Conclusion:The optical and DBT images were structurally consistent. The malignant tumors and benign lesions demonstrated different Hb T and scattering contrasts, which can potentially be exploited to reduce the false-positive rate of conventional mammography and unnecessary biopsies. BREAST IMAGING: Combined Optical and X-ray Tomosynthesis Breast Imaging Fang et al cancers and the reduction of the number of biopsies of benign lesions, compared with stand-alone conventional mammography.Our purpose was to explore the optical and physiologic properties of normal and lesion-bearing breasts by using a combined optical and DBT imaging system. Materials and MethodsThe experimental protocols were approved by the institutional review board (Massachusetts General Hospital), and written informed consent was obtained from all subjects. The study was compliant with Health Insurance Portability and Accountability Act guidelines. Imaging InstrumentationA photograph of the combined optical and DBT imaging system and probes is shown in Figures E1 and E2 (online). The detailed confi guration of the imaging physiologic parameters, such as the concentrations of oxygenated hemoglobin (Hb O ), deoxygenated hemoglobin (Hb R ), water, and lipids ( 16 ). With DOT, nearinfrared lasers, either radiofrequencymodulated, continuous-wave or pulsed, are used to probe tissue structure noninvasively ( 13,17 ). The concentrations of the tissue ...

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Section: Data Preprocessing and Image Reconstructionmentioning

confidence: 99%

Section: Imaging Instrumentationmentioning

confidence: 99%

Combined Optical and X-ray Tomosynthesis Breast Imaging

Fang¹,

Selb²,

Carp³

et al. 2011

Radiology

196

176

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“…In DBT, multiple low dose projections of the breast are acquired over a limited angular range; these projections are then used to calculate a pseudo-3D reconstruction of the imaged tissue. [2][3][4][5][6] Preliminary studies have shown that DBT has the potential to improve the clinical performance of breast cancer screening and/or diagnosis. [7][8][9][10][11][12] Current DBT systems, including the Selenia Dimensions (Hologic Inc., Bedford, MA) used in this study, lack x-ray scatter reduction measures, be it in software or hardware.…”

Section: Introductionmentioning

confidence: 99%

X‐ray scatter correction in breast tomosynthesis with a precomputed scatter map library

et al. 2014

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Purpose: To develop and evaluate the impact on lesion conspicuity of a software-based x-ray scatter correction algorithm for digital breast tomosynthesis (DBT) imaging into which a precomputed library of x-ray scatter maps is incorporated. Methods: A previously developed model of compressed breast shapes undergoing mammography based on principal component analysis (PCA) was used to assemble 540 simulated breast volumes, of different shapes and sizes, undergoing DBT. A Monte Carlo (MC) simulation was used to generate the cranio-caudal (CC) view DBT x-ray scatter maps of these volumes, which were then assembled into a library. This library was incorporated into a previously developed software-based x-ray scatter correction, and the performance of this improved algorithm was evaluated with an observer study of 40 patient cases previously classified as BI-RADS R 4 or 5, evenly divided between mass and microcalcification cases. Observers were presented with both the original images and the scatter corrected (SC) images side by side and asked to indicate their preference, on a scale from −5 to +5, in terms of lesion conspicuity and quality of diagnostic features. Scores were normalized such that a negative score indicates a preference for the original images, and a positive score indicates a preference for the SC images. Results: The scatter map library removes the time-intensive MC simulation from the application of the scatter correction algorithm. While only one in four observers preferred the SC DBT images as a whole (combined mean score = 0.169 ± 0.37, p > 0.39), all observers exhibited a preference for the SC images when the lesion examined was a mass (1.06 ± 0.45, p < 0.0001). When the lesion examined consisted of microcalcification clusters, the observers exhibited a preference for the uncorrected images (−0.725 ± 0.51, p < 0.009). Conclusions:The incorporation of the x-ray scatter map library into the scatter correction algorithm improves the efficiency of the algorithm. The observer study presented here is also the first test of the scatter correction algorithm with patient images and human observers, and demonstrates its potential to improve the clinical performance of DBT.

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“…The author concluded that MLEM algorithm provided a good balance of image quality between the low and high frequency features [3]. In another report, various DBT reconstruction methods have been explored previously [7]- [9]. In fact, to date, one study has quantitatively compared DBT algorithms in terms of image quality and radiation doses [10].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Different Reconstruction Algorithms for Decreasing the Exposure Dose during Digital Breast Tomosynthesis: A Phantom Study

Gomi¹

2015

JBiSE

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We compared reconstruction algorithms [filtered back projection (FBP), maximum likelihood expectation maximization (MLEM), and the simultaneous iterative reconstruction technique (SIRT)] in terms of the radiation dose and image quality, for exploring the possibility of decreasing the radiation dose during digital breast tomosynthesis (DBT). The three algorithms were implemented using a DBT system and experimentally evaluated using measurements, such as signal differenceto-noise ratio (SDNR) and intensity profile, on a BR3D phantom (in-focus plane image). The possible radiation dose reduction, contrast improvement, and artifact reduction in DBT were evaluated using different exposure levels and the three reconstruction techniques. We performed statistical analysis (one-way analysis of variance) of the SDNR data. The effectiveness of each technique for enhancing the visibility of the BR3D phantom was quantified with regard to SDNR (FBP versus MLEM, P < 0.05; FBP vs. SIRT, P < 0.05; MLEM vs. SIRT, P = 0.945); the artifact reduction was quantified with regard to the intensity profile. MLEM and SIRT produced reconstructed images with SDNR values indicative of low-contrast visibility. The SDNR value for the half-radiation dose MLEM and SIRT images was close to that of the FBP reference radiation dose image. Artifacts were decreased in the MLEM and SIRT images (in the in-focus plane) according to the intensity profiles that we obtained. With MLEM and SIRT, the radiation dose may be decreased to half comparison with FBP.

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Digital tomosynthesis mammography using a parallel maximum-likelihood reconstruction method

Cited by 43 publications

References 10 publications

Combined Optical and X-ray Tomosynthesis Breast Imaging

Combined Optical and X-ray Tomosynthesis Breast Imaging

X‐ray scatter correction in breast tomosynthesis with a precomputed scatter map library

Comparison of Different Reconstruction Algorithms for Decreasing the Exposure Dose during Digital Breast Tomosynthesis: A Phantom Study

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