The article explores the importance of cybersecurity in Industry 4.0, specifically focusing on safeguarding industrial automation systems from cyberattacks. It discusses essential security measures, network monitoring, and employee training, emphasizing the significance of risk management for ensuring industry stability. Adherence to industrial security standards, such as ISA/IEC 62443, is crucial (ISA—International Society of Automation, IEC—International Electrotechnical Commission). The article outlines cyberthreat challenges and their impact on various sectors, including healthcare and finance, as well as the risks faced by large industrial enterprises. Additionally, it elucidates evolving cybersecurity strategies and principles, underscoring the necessity for continuous, multi-layered protection. Collaboration with operators, strict information security policies, and robust incident response plans are emphasized. The importance of risk monitoring and adaptability to ever-changing threat landscapes is highlighted, emphasizing the collaborative and flexible nature of cybersecurity in the face of escalating digital threats.