This study explores the potential of inland navigation as a key component of Poland’s sustainable transportation strategy, focusing on the Opole–Szczecin route. It emphasizes inland waterways as an eco-friendly and efficient alternative to road and rail transport, potentially revitalizing local economies and reducing dependency on more traditional transport modes. The use of the River Information Service (RIS) system is highlighted as to its role in enhancing the logistical efficiency and safety of inland water transport. The research includes a comparative analysis of cargo transport on the Opole–Szczecin route, using road, rail, and inland-waterway options, revealing the advantages of inland-waterway transport in terms of cost-effectiveness and environmental impact. Finally, the paper discusses the challenges and opportunities for the development of inland navigation in Poland, advocating for greater integration with other transport branches through innovative technologies like RIS.