Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress

Li, Tongxi; Chen, Yifan; Tan, Peng; Shi, Hao; Huang, Zhiwei; Cai, Tianying; Chen, Yonglang; Du, Yichao; Fu, Wenguang

doi:10.1016/j.bioorg.2022.105737

Cited by 5 publications

(3 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DHA, known for reducing steatosis and inflammation in non-alcoholic steatohepatitis [ 18 ], but its ability to regulate AA metabolism remains unclear. Here, DHA was utilized to alleviate abnormal AA metabolism and inflammation in the liver of Yap1 LKO mice ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Dihydroartemisinin modulated arachidonic acid metabolism and mitigated liver inflammation by inhibiting the activation of 5-LOX and COX-2

Xue,

Lu,

Liu

et al. 2024

Heliyon

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Dihydroartemisinin modulated arachidonic acid metabolism and mitigated liver inflammation by inhibiting the activation of 5-LOX and COX-2

Xue,

Lu,

Liu

et al. 2024

Heliyon

View full text Add to dashboard Cite

“…The ER stress-mediated mitochondrial pathway was inhibited ( Chen et al, 2018 ). The activation of CHOP was improved ( Chen et al, 2019 ), the activation of ER stress was inhibited, and tissue damage was repaired ( Li et al, 2022 ).…”

Section: Role Of Artemisinin and Its Derivatives In Kidney Diseasementioning

confidence: 99%

Therapeutic potential of artemisinin and its derivatives in managing kidney diseases

et al. 2023

View full text Add to dashboard Cite

Artemisinin, an antimalarial traditional Chinese herb, is isolated from Artemisia annua. L, and has shown fewer side effects. Several pieces of evidence have demonstrated that artemisinin and its derivatives exhibited therapeutic effects on diseases like malaria, cancer, immune disorders, and inflammatory diseases. Additionally, the antimalarial drugs demonstrated antioxidant and anti-inflammatory activities, regulating the immune system and autophagy and modulating glycolipid metabolism properties, suggesting an alternative for managing kidney disease. This review assessed the pharmacological activities of artemisinin. It summarized the critical outcomes and probable mechanism of artemisinins in treating kidney diseases, including inflammatory, oxidative stress, autophagy, mitochondrial homeostasis, endoplasmic reticulum stress, glycolipid metabolism, insulin resistance, diabetic nephropathy, lupus nephritis, membranous nephropathy, IgA nephropathy, and acute kidney injury, suggesting the therapeutic potential of artemisinin and its derivatives in managing kidney diseases, especially the podocyte-associated kidney diseases.

show abstract

“…DHA is combined with piperaquine phosphate for malaria drugs. DHA has an anti‐inflammatory effect and has varied pharmacological activities 6–8 . The pernicious impact of DHA toward plasmodia is worked when ferrous iron (heme iron) cleaves the endoperoxide bridge of DHA, forming reactive oxygen species (ROS) and radicals.…”

Section: Introductionmentioning

confidence: 99%

Core–shell magnetic‐modified molecular imprinted polymer (Fe₃O₄@SiO₂@MIP) for dihydroartemisinin recognition and separation

Fauzia¹,

Andreas²,

Muzdalifah³

et al. 2023

Polymers for Advanced Techs

View full text Add to dashboard Cite

Dihydroartemisinin (DHA) is an artemisinin derivative compounds that employs as malaria drug. Extraction and purification artemisinin derivatives by liquid extraction utilize organic solvent and results in mixtures of compounds requiring further purification process. In this study, core-shell magnetic molecular imprinted polymer (Fe 3 O 4 @SiO 2 @MIP) has been synthesized for DHA isolation. Methacrylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA) were employed as monomer and cross-linker, respectively. Fe 3 O 4 was modified by tetraethyl orthosilicate (TEOS) to enhance stability and prevent aggregation. Nonimprinted polymer (Fe 3 O 4 @SiO 2 @NIP) was also prepared as a comparison. The Fourier transform infrared (FTIR) represented O O stretching of O O C bond (1,2,4-trioxane ring) at 825 cm À1 denoting that DHA has been successfully attached to MIP. Meanwhile, the morphology of Fe 3 O 4 @SiO 2 @MIP and Fe 3 O 4 @SiO 2 @NIP revealed uniform spherical-like form particle due to core-shell magnetic modification. The Brunaeur-Emmett-Teller (BET) revealed S BET of Fe 3 O 4 @SiO 2 @MIP and Fe 3 O 4 @SiO 2 @-NIP was 70.16 and 19.56 m 2 g À1 , respectively. The prepared materials owned a superparamagentic behavior as indicated by narrow loop and low remanence and coercivity.The binding study indicated that Fe 3 O 4 @SiO 2 @MIP and Fe 3 O 4 @SiO 2 @NIP were achieved optimum condition at pH 4, contact time 90 min and initial concentration 8 mg L À1 with adsorption capacity (q exp ) 1.026 mg g À1 for Fe 3 O 4 @SiO 2 @MIP and 0.806 for Fe 3 O 4 @SiO 2 @NIP. The selectivity of Fe 3 O 4 @SiO 2 @MIP was more than 60% in all over the ratio. The prepared MIP exhibited good selectivity toward DHA with imprinting factor (IF) 2.14 and selectivity coefficient (α) 3.43. The percent adsorption of Fe 3 O 4 @-SiO 2 @MIP did not changed after three times adsorption-desorption cycles. The result exhibited that Fe 3 O 4 @SiO 2 @MIP could effectively be used for DHA separation.

show abstract

Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress

Cited by 5 publications

References 49 publications

Dihydroartemisinin modulated arachidonic acid metabolism and mitigated liver inflammation by inhibiting the activation of 5-LOX and COX-2

Dihydroartemisinin modulated arachidonic acid metabolism and mitigated liver inflammation by inhibiting the activation of 5-LOX and COX-2

Therapeutic potential of artemisinin and its derivatives in managing kidney diseases

Core–shell magnetic‐modified molecular imprinted polymer (Fe₃O₄@SiO₂@MIP) for dihydroartemisinin recognition and separation

Contact Info

Product

Resources

About

Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress

Cited by 5 publications

References 49 publications

Dihydroartemisinin modulated arachidonic acid metabolism and mitigated liver inflammation by inhibiting the activation of 5-LOX and COX-2

Dihydroartemisinin modulated arachidonic acid metabolism and mitigated liver inflammation by inhibiting the activation of 5-LOX and COX-2

Therapeutic potential of artemisinin and its derivatives in managing kidney diseases

Core–shell magnetic‐modified molecular imprinted polymer (Fe3O4@SiO2@MIP) for dihydroartemisinin recognition and separation

Contact Info

Product

Resources

About

Core–shell magnetic‐modified molecular imprinted polymer (Fe₃O₄@SiO₂@MIP) for dihydroartemisinin recognition and separation