Dimensional Ridge Alterations and Histomorphometric Analysis Following Socket Preservation With PRF or Allograft. Randomized Controlled Clinical Study

Ivanova, Vasilena; Chenchev, Ivan; Zlatev, Stefan; Kanazirski, Nikolay

doi:10.5272/jimab.2019254.2853

Cited by 3 publications

(6 citation statements)

References 1 publication

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“…2 and Supplementary data). The results of this systematic review show a moderate effect and a moderate certainty of the evidence, with methodological variability between studies 22…”

Section: Resultsmentioning

confidence: 72%

“…Advanced-PRF preparation protocol varied from 9, 10, and 20 mL of venous blood drawn in sterile vacuum plain tubes for A-PRF, without any additive or anticoagulant, centrifuged at 1300 RPM (200 g ) for 8 minutes to 13 minutes22–24 (Table 2, Supplemental, Supplemental Digital Content 1, http://links.lww.com/SCS/E923 and Fig. 3).…”

Section: Resultsmentioning

confidence: 99%

“…Despite this, this systematic review suggests an additional regenerative potential of A-PRF for oral surgical procedures that remains underestimated in the literature. Unfortunately, the certainty of the evidence is still limited by the number of primary studies, methodological issues, and the impossibility of meta-analysis 11,12,20–24…”

Section: Discussionmentioning

confidence: 99%

“…Among the 7 domains of quality assessment of the 5 included studies (≅ 37%) were low risk of bias or high risk of bias, and (≅ 26%) were uncertain risk of bias; Clark et al 21 showed a low risk of bias, 2 studies showed a high risk of bias 23,24 or uncertain risk of bias 20,22 (Fig. 2 and Supplementary data).…”

Section: Risk Of Bias (Quality Assessment) and Size Effect Estimatementioning

confidence: 99%

“…The results of this systematic review show a moderate effect and a moderate certainty of the evidence, with methodological variability between studies. 22 1300 RPM (200g) for 8 minutes to 13 minutes [22][23][24] (Table 2, Supplemental, Supplemental Digital Content 1, http://links. lww.com/SCS/E923 and Fig.…”

Section: Risk Of Bias (Quality Assessment) and Size Effect Estimatementioning

confidence: 99%

See 4 more Smart Citations

The Effect of Advanced Platelet-Rich Fibrin in Tissue Regeneration in Reconstructive and Graft Surgery: Systematic Review

Pereira

Barbirato

Lago

et al. 2023

Journal of Craniofacial Surgery

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This systematic review answered the guiding question using the PICO system: “What are the effects of advanced platelet-rich fibrin (A-PRF) on alveolar ridge preservation and tissue gain in reconstructive and jaw graft surgery?” Searches were performed in the PubMed|MEDLINE, Scopus, Embase, Web of Science, Cochrane Library, and LILACS|bvs databases. In total, 573 articles were found in the initial search, and 564 were evaluated after the removal of duplicates, of which 5 randomized controlled trials met the eligibility criteria and were included 2 studies investigated the effect of A-PRF on the preservation of the bone ridge, 1 study evaluated the tissue repair after tooth extraction with A-PRF, 1 evaluated the peri-implant gap filling with A-PRF-xenograft mixture, and other the A-PRF on the treatment of alveolar osteitis. Advanced-PRF preparation protocol varied between the included studies from 8 to 13 minutes of centrifugation, at 1300 RPM (200g). The use of A-PRF provided greater dimensions of height and more favorable maintenance of the ridge profile, probing depth, and gingival margin level after extraction. Advanced-PRF also increased bone density, vital bone, epithelial healing, and control of postoperative pain and swelling after tooth extraction and in the treatment of alveolar osteitis.

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“…2 and Supplementary data). The results of this systematic review show a moderate effect and a moderate certainty of the evidence, with methodological variability between studies 22…”

Section: Resultsmentioning

confidence: 72%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Risk Of Bias (Quality Assessment) and Size Effect Estimatementioning

confidence: 99%

Section: Risk Of Bias (Quality Assessment) and Size Effect Estimatementioning

confidence: 99%

See 3 more Smart Citations

The Effect of Advanced Platelet-Rich Fibrin in Tissue Regeneration in Reconstructive and Graft Surgery: Systematic Review

Pereira

Barbirato

Lago

et al. 2023

Journal of Craniofacial Surgery

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Effect of the use of platelet concentrates on new bone formation in alveolar ridge preservation: a systematic review, meta-analysis, and trial sequential analysis

et al. 2023

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Objectives To investigate the histomorphometric changes occurring in alveolar ridge preservation (ARP) based on the use of different plasma concentrates (PCs) in randomized clinical trials (RCT). There is controversy whether the placement of PCs in ARP is effective in the formation of new bone. Materials and methods A systematic review search was conducted in PubMed, Scopus, Web of Science, and Cochrane Database to answer the PICO question: In patients undergoing tooth extraction followed by ARP, do PCs alone in the post-extraction socket in comparison with spontaneous healing improve new vital bone formation percentage in histomorphometric analysis after more than 10 weeks? The risk of bias was assessed and a meta-analysis was conducted. Results Of 3809 results, 8 studies were considered suitable for inclusion. A total of 255 teeth were extracted in 250 patients. Regarding the PCs used, ARP was performed with platelet- and leukocyte-rich fibrin (L-PRF) in 120 sockets, and with pure platelet-rich plasma (P-PRP) in 31 sockets and 104 sockets were controlled. PCs improved new bone formation in ARP with respect to the spontaneous healing group (SMD = 1.77, 95%C.I. = 1.47–2.06, p-value < 000.1). There were no differences between the different PCs (L-PRF and P-PRP). Conclusion The results of this meta-analysis support the efficacy of the use of PCs in new bone formation in ARP. With respect to the different types of PCs studied, no differences were observed. Clinical relevance When planning implant surgery after tooth extraction, treatment with PCs should be considered for ARP. Any PC increases new bone formation compared to spontaneous healing.

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Autologous platelet concentrates in alveolar ridge preservation: A systematic review with meta‐analyses

Siawasch,

Yu,

Castro

et al. 2024

Periodontology 2000

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In order to evaluate the therapeutic advantages of various autologous platelet concentrates (APC) as a single biomaterial during alveolar ridge preservation (ARP), a systematic review with meta‐analyses was conducted. PubMed, EMBASE, Web of Science, and Scopus were screened for randomized controlled trials (RCTs) that were released prior to 2024. The selected papers compared an APC with either unassisted healing (blood clot) or another biomaterial during ARP (third molars were not included). The outcome parameters included alveolar bone dimension alterations, soft tissue healing, and post‐op pain intensity. The search yielded 35 papers (33 studies), one applying platelet‐rich plasma (PRP), six using plasma rich in growth factors (PRGF), and 28 using leukocyte‐ and platelet‐rich fibrin (L‐PRF). These studies showed a large heterogeneity (e.g., outcome parameters, timing, surgical approach, and inclusion criteria), which hindered drawing strong conclusions. In most studies, however, ARP with PRP, PRGF, and L‐PRF alone produced faster soft tissue healing, less post‐extraction pain, less alveolar ridge resorption, more socket bone fill, and a higher bone density when compared to unassisted (spontaneous) healing. The ultimate benefit appears to be significantly influenced by the surgical approach. Limited literature exists comparing APC with other biomaterials for ARP, resulting in inconclusive data. APC application for ARP is a promising strategy to improve soft and hard tissue healing and reduce post‐extraction pain.

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Dimensional Ridge Alterations and Histomorphometric Analysis Following Socket Preservation With PRF or Allograft. Randomized Controlled Clinical Study

Cited by 3 publications

References 1 publication

The Effect of Advanced Platelet-Rich Fibrin in Tissue Regeneration in Reconstructive and Graft Surgery: Systematic Review

The Effect of Advanced Platelet-Rich Fibrin in Tissue Regeneration in Reconstructive and Graft Surgery: Systematic Review

Effect of the use of platelet concentrates on new bone formation in alveolar ridge preservation: a systematic review, meta-analysis, and trial sequential analysis

Autologous platelet concentrates in alveolar ridge preservation: A systematic review with meta‐analyses

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