Dimeric furanocoumarins from the roots of Angelica dahurica

Abstract

Three new dimeric furanocoumarins, dahuribiethrins H-J (1-3), and a new ester coumarin, dahurinol A (4), were isolated from the roots of Angelica dahurica. Their structures were elucidated on the basis of extensive spectroscopic data including UV, IR, HRESIMS, 1D and 2D NMR. Compounds 2 and 3 exhibited inhibition of nitric oxide production in the lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells with IC values of 8.7 ± 0.6 and 27.3 ± 0.9 μM, respectively.

Imperatorin Suppresses Anaphylactic Reaction and IgE-Mediated Allergic Responses by Inhibiting Multiple Steps of FceRI Signaling in Mast Cells: IMP Alleviates Allergic Responses in PCA

“…IMP is a Chinese medicinal ingredient of coumarins. It has been shown that IMP has several pharmacological effects, such as anti-inflammatory, anticonvulsant, antitumoral, antihypertensive, vasodilatation, and antihypertrophic effects [12, 19–21]. Administration of the single, effective compound could enhance the bioavailability and decrease the side effects.…”

“…Imperatorin (IMP) (9-(3-methylbut-2-enyloxy)-7H-furo[3,2-g]chromen-7-one) is the main component of the dried root or rhizome of Radix Angelicae Dahuricae . IMP has been shown to have versatile pharmacological effects, including the anti-inflammatory effect [12, 13]. A previous study has demonstrated that IMP decreases the inflammatory reaction by inhibiting the TNF- α -mediated activation of ROS/PI3K/Akt/NF- κ B pathway [14].…”

Botanical Sources, Chemistry, Analysis, and Biological Activity of Furanocoumarins of Pharmaceutical Interest

“…In general, polar solvents, such as water (H 2 O), methanol (MeOH), ethanol (EtOH), acetone, and their aqueous mixtures, are the most widely used as extraction solvents [47,49,50,51,52,53,54,55,57,58,60,61,62,63,64,65,66,67,68,69,70,71,72,73]. The use of EtOAc, chloroform, dichloromethane, and petroleum ether has also been described in the literature [56,59,61,67,74,75,76,77,78].…”

Natural Products Research in China From 2015 to 2016

“…Three new dimeric furanocoumarins, dahuribiethrins H–J, were also isolated from roots of Angelica dahurica (Anhui, China). Dahuribiethrins H ( 379 ) and I ( 380 ) inhibited LPS-stimulated NO production in RAW 264.7 macrophage cells with IC 50 values of 8.7 and 27.3 μM (indometacin, 38.6 μM) (Yang et al, 2017 ). Arylalkenyl α,β-unsaturated δ-lactone cryptoconcatones A–H, along with arylalkenyl α,β-unsaturated γ-lactone cryptoconcatones I and J, were isolated from the leaves and twigs of Cryptocarya concinna (Guangdong, China).…”