Dimethyl-β-cyclodextrin/salazosulfapyridine inclusion complex-loaded chitosan nanoparticles for sustained release

Hydroxypropyl‐β‐cyclodextrin hybrid nanogels as nano‐drug delivery carriers to enhance the solubility of dexibuprofen: Characterization, in vitro release, and acute oral toxicity studies

“…The release rate of crystalline drugs incorporated into cyclodextrins will depend on degree and type of this structure, as well as the physicochemical characteristics of drug. Generally, interactions of drug with cyclodextrin play a critical role in dissolution profile of drug . Therefore, complexation can be assessed by changes in characteristic peaks of complex as compared to pure drug molecules by analyzing X‐ray diffraction .…”

Mechanistic Investigation of Inclusion Complexes of a Sulfa Drug with α- and β-Cyclodextrins

“…The stabilization and regulatory release of sulfa drugs are of great concern in pharmacology. − Thus, to protect these drugs from external effects and to regulate their release, it is crucial to investigate whether they can be encapsulated within CD molecules. , Sulfonamides are bacteriostatic materials, and the ranges of activity are analogous for all sulfonamides. , Sulfonamides restrain bacterial synthesis of dihydrofolic acid by inhibiting the condensation of the pteridine with aminobenzoic acid through competitive inhibition of the enzyme dihydropteroate synthetase. , Topically applied sulfonamides act against vulnerable strains of various bacterial eye pathogens, for example, Escherichia coli , Staphylococcus aureus , Streptococcus pneumoniae , Streptococcus, Haemophilus influenzae , Klebsiella species, and Enterobacter species. , Sulfacetamide sodium (SS) (Scheme ) 10% topical lotion is approved for the treatment of acne, seborrheic dermatitis, conjunctivitis, and various external visual infections due to microorganisms. , SS has been considered in the treatment of pityriasis versicolor and rosacea . It also has antiinflammatory properties when used to treat conjunctivitis .…”

Pulmonary delivery of tea tree oil-β-cyclodextrin inclusion complexes for the treatment of fungal and bacterial pneumonia

“…The cavity of b-CD is appropriate for entrapment of various organic molecules. The complexes may increase drug stability, [15] solubility [16] and bioavailability, [17] and alleviate local irritation. [18,19] Moreover, volatile oils can be transformed to their CD complex solid powders against evaporation.…”